The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly

Journal of Biological Chemistry

Volumn 286, Issue 39, 2011, Pages 33992-33998

  Archuleta, Tara L ^a   Du, Yaqing ^a   English, Chauca A ^a   Lory, Stephen ^b   Lesser, Cammie ^b,c   Ohi, Melanie D ^a   Ohi, Ryoma ^a   Spiller, Benjamin W ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL EFFECTOR; BIOCHEMICAL ACTIVITY; GENETIC MANIPULATIONS; HETEROLOGOUS EXPRESSION; HOST CELLS; INTRACELLULAR PATHOGENS; MICROTUBULE ASSEMBLY; MICROTUBULES; MITOTIC ARREST; MULTIDOMAIN PROTEINS; SEQUENCE IDENTITY; STATHMIN; TUBULIN POLYMERIZATION; TYPE THREE SECRETION SYSTEMS;

CELLS; ENZYME ACTIVITY; PHYSIOLOGY;

PROTEINS;

BACTERIAL PROTEIN; CHAPERONE; CHLAMYDIA OUTER PROTEIN N; STATHMIN; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHLAMYDIA; CHLAMYDOPHILA PSITTACI; COMPLEX FORMATION; GEL FILTRATION; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; CATTLE; CHLAMYDIA; CHLAMYDIA INFECTIONS; METAPHASE; MICROTUBULES; MITOTIC SPINDLE APPARATUS; TUBULIN; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); CHLAMYDIA;

EID: 80053207286     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.258426     Document Type: Article

References (64)

1. Fields, K. A., and Hackstadt, T. (2000) Mol. Microbiol. 38, 1048-1060
2. Hsia, R. C., Pannekoek, Y., Ingerowski, E., and Bavoil, P. M. (1997) Mol. Microbiol. 25, 351-359
3. Valdivia, R. H. (2008) Curr. Opin. Microbiol. 11, 53-59
4. Huang, J., Lesser, C. F., and Lory, S. (2008) Nature 456, 112-115
5. Manna, T., Thrower, D. A., Honnappa, S., Steinmetz, M. O., and Wilson, L. (2009) J. Biol. Chem. 284, 15640-15649
6. Manna, T., Thrower, D., Miller, H. P., Curmi, P., and Wilson, L. (2006) J. Biol. Chem. 281, 2071-2078
7. Ravelli, R. B., Gigant, B., Curmi, P. A., Jourdain, I., Lachkar, S., Sobel, A., and Knossow, M. (2004) Nature 428, 198-202
8. Jourdain, I., Lachkar, S., Charbaut, E., Gigant, B., Knossow, M., Sobel, A., and Curmi, P. A. (2004) Biochem. J. 378, 877-888
9. Cassimeris, L. (2002) Curr. Opin. Cell Biol. 14, 18-24
10. Gigant, B., Curmi, P. A., Martin-Barbey, C., Charbaut, E., Lachkar, S., Lebeau, L., Siavoshian, S., Sobel, A., and Knossow, M. (2000) Cell 102, 809-816
11. Curmi, P. A., Andersen, S. S., Lachkar, S., Gavet, O., Karsenti, E., Knossow, M., and Sobel, A. (1997) J. Biol. Chem. 272, 25029-25036
12. Belmont, L. D., and Mitchison, T. J. (1996) Cell 84, 623-631
13. Howell, B., Larsson, N., Gullberg, M., and Cassimeris, L. (1999) Mol. Biol. Cell 10, 105-118
14. Saka, H. A., and Valdivia, R. H. (2010) Curr. Opin. Microbiol. 13, 4-10
15. Ho, T. D., and Starnbach, M. N. (2005) Infect. Immun. 73, 905-911
16. Engel, J. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 9947-9948
17. Moulder, J. W. (1991) Microbiol. Rev. 55, 143-190
18. Grieshaber, S. S., Grieshaber, N. A., Miller, N., and Hackstadt, T. (2006) Traffic 7, 940-949
19. Grieshaber, S. S., Grieshaber, N. A., and Hackstadt, T. (2003) J. Cell Sci. 116, 3793-3802
20. Mital, J., Miller, N. J., Fischer, E. R., and Hackstadt, T. (2010) Cell. Microbiol. 12, 1235-1249
21. Cornelis, G. R. (2006) Nat. Rev. Microbiol. 4, 811-825
22. Ghosh, P. (2004) Microbiol. Mol. Biol. Rev. 68, 771-795
23. Dean, P., and Kenny, B. (2009) Curr. Opin. Microbiol. 12, 101-109
24. Schroeder, G. N., and Hilbi, H. (2008) Clin. Microbiol. Rev. 21, 134-156
25. Johnson, S., Deane, J. E., and Lea, S. M. (2005) Curr. Opin. Struct. Biol. 15, 700-707
26. Cossart, P., and Sansonetti, P. J. (2004) Science 304, 242-248
27. Yoshida, S., and Sasakawa, C. (2003) Trends Microbiol. 11, 139-143
28. Desai, A., and Mitchison, T. J. (1997) Annu. Rev. Cell Dev. Biol. 13, 83-117
29. Balsara, Z. R., Misaghi, S., Lafave, J. N., and Starnbach, M. N. (2006) Infect. Immun. 74, 5602-5608
30. Pallen, M. J., Beatson, S. A., and Bailey, C. M. (2005) BMC Microbiol. 5, 9
31. Schubot, F. D., Jackson, M. W., Penrose, K. J., Cherry, S., Tropea, J. E., Plano, G. V., and Waugh, D. S. (2005) J. Mol. Biol. 346, 1147-1161
32. Deng, W., Li, Y., Hardwidge, P. R., Frey, E. A., Pfuetzner, R. A., Lee, S., Gruenheid, S., Strynakda, N. C., Puente, J. L., and Finlay, B. B. (2005) Infect. Immun. 73, 2135-2146
33. Deane, J. E., Roversi, P., King, C., Johnson, S., and Lea, S. M. (2008) J. Mol. Biol. 377, 985-992
34. Slepenkin, A., De la Maza, L. M., and Peterson, E. M. (2005) J. Bacteriol. 187, 473-479
35. Castoldi, M., and Popov, A. V. (2003) Protein Expr. Purif. 32, 83-88
36. Du, Y., English, C. A., and Ohi, R. (2010) Curr. Biol. 20, 374-380
37. Roger, B., Al-Bassam, J., Dehmelt, L., Milligan, R. A., and Halpain, S. (2004) Curr. Biol. 14, 363-371
38. Germane, K. L., Ohi, R., Goldberg, M. B., and Spiller, B. W. (2008) Biochemistry 47, 10241-10243
39. Desai, A., Verma, S., Mitchison, T. J., and Walczak, C. E. (1999) Cell 96, 69-78
40. Hyman, A., Drechsel, D., Kellogg, D., Salser, S., Sawin, K., Steffen, P., Wordeman, L., and Mitchison, T. (1991) Methods Enzymol. 196, 478-485
41. Ohi, M., Li, Y., Cheng, Y., and Walz, T. (2004) Biol. Proced. Online 6, 23-34
42. Rodgers, L., Gamez, A., Riek, R., and Ghosh, P. (2008) J. Biol. Chem. 283, 20857-20863
43. Lilic, M., Vujanac, M., and Stebbins, C. E. (2006) Mol. Cell 21, 653-664
44. Stebbins, C. E., and Galán, J. E. (2001) Nature 414, 77-81
45. Spaeth, K. E., Chen, Y. S., and Valdivia, R. H. (2009) PLoS Pathog. 5, e1000579
46. Lachkar, S., Lebois, M., Steinmetz, M. O., Guichet, A., Lal, N., Curmi, P. A., Sobel, A., and Ozon, S. (2010) J. Biol. Chem. 285, 11667-11680
47. Parsot, C., Hamiaux, C., and Page, A. L. (2003) Curr. Opin. Microbiol. 6, 7-14
48. Fields, K. A., Fischer, E. R., Mead, D. J., and Hackstadt, T. (2005) J. Bacteriol. 187, 6466-6478
49. Büttner, C. R., Sorg, I., Cornelis, G. R., Heinz, D. W., and Niemann, H. H. (2008) J. Mol. Biol. 375, 997-1012
50. Lunelli, M., Lokareddy, R. K., Zychlinsky, A., and Kolbe, M. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 9661-9666
51. Weisenberg, R. C., Deery, W. J., and Dickinson, P. J. (1976) Biochemistry 15, 4248-4254
52. Mitchison, T., and Kirschner, M. (1984) Nature 312, 237-242
53. Margolis, R. L., and Wilson, L. (1978) Cell 13, 1-8
54. Slep, K. C. (2010) Curr. Opin. Cell Biol. 22, 88-95
55. Slep, K. C., and Vale, R. D. (2007) Mol. Cell 27, 976-991
56. Al-Bassam, J., van Breugel, M., Harrison, S. C., and Hyman, A. (2006) J. Cell Biol. 172, 1009-1022
57. Steinmetz, M. O. (2007) J. Struct. Biol. 158, 137-147
58. Schlumberger, M. C., Müller, A. J., Ehrbar, K., Winnen, B., Duss, I., Stecher, B., and Hardt, W. D. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 12548-12553
59. Skilton, R. J., Cutcliffen, L. T., Barlow, D., Wang, Y., Salim, O., Lambden, P. R., and Clarke, I. N. (2009) PLoS ONE 4, e7723
60. Campbell, L. A., and Kuo, C. C. (2009) Curr. Protoc. Microbiol. 11, 11B.1
61. Mukhopadhyay, S., Clark, A. P., Sullivan, E. D., Miller, R. D., and Summersgill, J. T. (2004) J. Clin. Microbiol. 42, 3288-3290
62. Hiller, G., and Weber, K. (1978) Cell 14, 795-804
63. Bulinski, J. C., Morgan, J. L., Borisy, G. G., and Spooner, B. S. (1980) Anal. Biochem. 104, 432-439
64. Howard, J., and Hyman, A. A. (2007) Curr. Opin. Cell Biol. 19, 31-35