Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity

Journal of Peptide Science

Volumn 17, Issue 10, 2011, Pages 683-689

  Narayanaswamy, Venugopala K ^a   Albericio, Fernando ^b,c   Coovadia, Yacoob Mohamed ^d   Kruger, Hendrik G ^a   Maguire, Glenn E M ^a   Pillay, Melendhran ^d   Govender, Thavendran ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d INKOSI ALBERT LUTHULI CENTRAL HOSPITAL   (South Africa)

Author keywords

Antitubercular activity; Cyclic depsipeptides; HRMS characterization; Linear peptides; Macrolactonization reaction; Solid phase peptide synthesis

Indexed keywords

1,2 PIPERAZINE 3 CARBOXYLIC ACID; CARBOXYLIC ACID; DEPSIDOMYCIN; DEPSIDOMYCIN DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MACROLACTONIZATION; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANT TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE SYNTHESIS;

ANTITUBERCULAR AGENTS; CARBOXYLIC ACIDS; IMMUNOSUPPRESSIVE AGENTS; LACTONES; MICROBIAL SENSITIVITY TESTS; OLIGOPEPTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

STREPTOMYCES LAVENDOFOLIAE;

EID: 80053192948     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1389     Document Type: Article

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