Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 4853-4858

  Fallah Tafti, Asal ^a   Foroumadi, Alireza ^a   Tiwari, Rakesh ^b   Shirazi, Amir Nasrolahi ^b   Hangauer, David G ^c   Bu, Yahao ^c   Akbarzadeh, Tahmineh ^a   Parang, Keykavous ^b   Shafiee, Abbas ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c Kinex Pharmaceuticals   (United States)

Author keywords

Anticancer; Cell proliferation; Inhibitor; KX 2; Src kinase; Thiazole

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENEACETAMIDE DERIVATIVE; KX 2 391; N (2 CHLOROBENZYL) 2 [2 (4 (2 MORPHOLINOETHOXY)PHENYL)THIAZOL 4 YL]ACETAMIDE; N (3,4 DICHLOROBENZYL) 2 [2 (4 (2 MORPHOLINOETHOXY)PHENYL)THIAZOL 4 YL]ACETAMIDE; N (4 FLUOROBENZYL) 2 [2 (4 (2 MORPHOLINOETHOXY)PHENYL)THIAZOL 4 YL]ACETAMIDE; N (4 METHYLBENZYL) 2 [2 (4 (2 MORPHOLINOETHOXY)PHENYL)THIAZOL 4 YL]ACETAMIDE; N BENZYL 2 [2 (4 (2 MORPHOLINOETHOXY)PHENYL)THIAZOL 4 YL]ACETAMIDE; N BENZYL 2 [5 (4 (2 MORPHOLINOETHOXY)PHENYL)PYRIDIN 2 YL]ACETAMIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIDINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CARCINOMA CELL; CELL PROLIFERATION; CELL STRAIN 3T3; COLON CARCINOMA; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LEUKEMIA CELL; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA; MICE; NIH 3T3 CELLS; PROTEIN KINASE INHIBITORS; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 80053185093     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.050     Document Type: Article

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