Anti-angiogenic effects of water extract of a formula consisting of pulsatilla koreana, panax ginseng and glycyrrhiza uralensis

Journal of Chinese Integrative Medicine

Volumn 9, Issue 9, 2011, Pages 1005-1013

  Kim, Jong Min ^a   Kim, Kyung Soon ^a   Lee, Yeon Weol ^a   Cho, Chong Kwan ^a   Yoo, Hwa Seung ^a   Bang, Ji Young ^b   Kim, Eung Yoon ^b   Kang, In Cheol ^b  

^a Daejeon University   (South Korea)

^b Hoseo University   (South Korea)

Author keywords

Angiogenesis inhibitors; Cyclin a; Focal adhesion protein tyrosine kinases; Glycyrrhiza uralensis; In vitro; Panax ginseng; Plant extracts; Pulsatilla

Indexed keywords

ANGIOGENESIS INHIBITOR; CYCLIN A; FIBROBLAST GROWTH FACTOR; FOCAL ADHESION KINASE; GINSENG EXTRACT; GLYCYRRHIZA URALENSIS EXTRACT; NIBRIN; PLANT EXTRACT; PROTEIN P57; PROTEIN P63; PULSATILLA KOREANA EXTRACT; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CAPILLARY PROLIFERATION; CAPILLARY TUBE FORMATION; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CHORIOALLANTOIS; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MEDICINAL PLANT; PROTEIN EXPRESSION; PULSATILLA KOREANA; SOLVENT EXTRACTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INDUCING AGENTS; CELL MOVEMENT; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; GLYCYRRHIZA URALENSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PANAX; PULSATILLA;

EID: 80053184641     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20110912     Document Type: Article

References (27)

1. Fan TP, Jaggar R, Bicknell R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci. 1995; 16(2): 57-66.
2. Bussolino F, Mantovani A, Persico G. Molecular mechanisms of blood vessel formation. Trends Biochem Sci. 1997; 22(7): 251-256.
3. Redlitz A, Daum G, Sage EH. Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells. J Vase Res. 1999; 36(1): 28-34.
4. Teruyama K, Abe M, Nakano T, Iwasaka-Yagi C, Takahashi S, Yamada S, Sato Y. Role of transcription factor Ets-1 in the apoptosis of human vascular endothelial cells. J Cell Physiol. 2001; 188(2): 243-252.
5. Segura I, Serrano A, De Buitrago GG, Gonzalez MA, Abad JL, Claveria C, Gomez L, Bernad A, Martinez-A C, Riese HH. Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis. FASEBJ. 2002; 16(8): 833-841.
6. Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N. Discovery of [4-amino-2-(1-methanesulfo-nylpiperidin-4-ylamino) pyrimidin-5-yl] (2, 3-difluoro-6-methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J Med Chem. 2006; 49(22): 6549-6560.
7. Raghu H, Sodadasu PK, Malla RR, Gondi CS, Estes N, Rao JS. Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells. BMC Cancer. 2010; 10: 647.
8. Mitra SK, Schlaepfer DD. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol. 2006; 18(5): 516-523.
9. Gurevich F, Perazella MA. Renal effects of anti-angiogenesis therapy: update for the internist. Am J Med. 2009; 122(4): 322-328.
10. Kang WK, Park YS, Lee DH, Kwon KE. Pharmacokinetics of anticancer agent SB-31 in rats &. rabbits and the cardiovascular effect on the isolated perfused rat heart &. blood coagulation. Kor J Clin Pharm. 1998; 8 (2): 122-132.Korean with abstract in English.
11. Kim SY, Kim SB. Anti-tumor effects of extracts of Pulsatilla koreana (SB-31) in vitro. J Kor Cancer Assoc. 1994; 26(6): 959-963.
12. Bang SC, Lee JH, Song GY, Kim DH, Yoon MY, Ahn BZ. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Chem Pharm Bull (Tokyo). 2005; 53(11): 1451-1454.
13. Wickstrom SA, Alitalo K, Keski-Oja J. An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. J Biol Chem. 2004; 279(19): 20178-20185.
14. Cattaneo MG, Pola S, Francescato P, Chillemi F, Vicentini LM. Human endostatin-derived synthetic peptides possess potent antiangiogenic properties in vitro and in vivo. Exp Cell Res. 2003; 283(2): 230-236.
15. Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA. Integrin av(33 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994; 79(7): 1157-1164.
16. Ferguson TA, Mizutani H, Kupper TS. Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo. Proc Natl Acad Sci USA. 1991; 88 (18): 8072-8076.
17. Hamburger V. A manual of experimental embryology. Revised ed. Chicago: University of Chicago Press. 1960: 143-173.
18. Ajjappala BS, Kim MS, Kim EY, Kim JH, Kang IC, Baek KH. Protein chip analysis of pluripotency-associated proteins in NIH3T3 fibroblast. Proteomics. 2009; 9 (16): 3968-3978.
19. Andersson O, Kozlowski M, Garachtchenko T, Nikoloff C, Lew N, Litman DJ, Chaga G. Determination of relative protein abundance by internally normalized ratio algorithm with antibody arrays. J Proteome Res. 2005; 4(3): 758-767.
20. Kim Y, Bang SC, Lee JH, Ahn BZ. Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana. Arch Pharm Res. 2004; 27(9): 915-918.
21. Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA. Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene. 2000; 19(49): 5606-5613.
22. Zhao J, Zheng C, Guan J. Pyk2 and FAK differentially regulate progression of the cell cycle. J Cell Sci. 2000; 113(Pt 17): 3063-3072.
23. Wang S, Hasham MG, Isordia-Salas I, Tsygankov AY, Colman RW, Guo YL. Upregulation of Cdc2 and cyclin A during apoptosis of endothelial cells induced by cleaved high-molecular-weight kininogen. Am J Physiol Heart Circ Physiol. 2003; 284(6): H1917-H1923.
24. Pardini B, Naccarati A, Polakova V, Smerhovsky Z, Hlavata I, Soucek P, Novotny J, Vodickova L, Tomanova V, Landi S, Vodicka P. NBN 657del5 heterozygous mutations and colorectal cancer risk in the Czech Republic. Mutat Res. 2009; 666(1-2): 64-67.
25. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH. The hMrell/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell. 1998; 93(3): 477-486.
26. Piekutowska-Abramczuk D, Ciara E, Popowska E, Grajkowska W, Dembowska-Baginska B, Kowalewska E, Czajnska A, Perek-Polnik M, Roszkowski M, Syczewska M, Krajewska-Walasek M, Perek D, Chrzanowska KH. The frequency of NBN molecular variants in pediatric astrocytic tumors. J Neurooncol. 2010; 96(2): 161-168.
27. Schmit TL, Ledesma MC, Ahmad N. Modulating pololike kinase 1 as a means for cancer chemoprevention. Pharm Res. 2010; 27(6): 989-998.