A prospective cohort study of light transmission platelet aggregometry for bleeding disorders: Is testing native platelet-rich plasma non-inferior to testing platelet count adjusted samples?

Thrombosis and Haemostasis

Volumn 106, Issue 4, 2011, Pages 675-682

  Castilloux, Jean Francois ^a   Moffat, Karen A ^a   Liu, Yang ^a   Seecharan, Jodi ^a   Pai, Menaka ^a   Hayward, Catherine P M ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Acquired; Clinical studies; Inherited; Platelet disorders; Platelet pathology

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ARACHIDONIC ACID; COLLAGEN; RISTOCETIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLEEDING DISORDER; BLOOD ANALYSIS; BLOOD SAMPLING; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; INTERMETHOD COMPARISON; LIGHT TRANSMISSION PLATELET AGGREGOMETRY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PATIENT REFERRAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE RELEASE REACTION; THROMBOCYTE RICH PLASMA;

ADENOSINE DIPHOSPHATE; ADULT; BLOOD COAGULATION DISORDERS; BLOOD PLATELETS; CELLS, CULTURED; COHORT STUDIES; COLLAGEN; EPINEPHRINE; FEASIBILITY STUDIES; FEMALE; HEMORRHAGE; HUMANS; LIGHT; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET COUNT; PLATELET FUNCTION TESTS; PLATELET-RICH PLASMA; PROSPECTIVE STUDIES;

EID: 80053183746     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-06-0378     Document Type: Article

References (21)

1. Hayward CP. Diagnostic evaluation of platelet function disorders. Blood Rev 2011; 25: 169-173.
2. Hayward CP, Pai M, Liu Y, et al. Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments. J Thromb Haemost 2009; 7: 676-684.
3. Quiroga T, Goycoolea M, Matus V, et al. Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays. Br J Haematol 2009; 147: 729-736.
4. Cattaneo M: Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function. Semin Thromb Hemost 2009; 35: 158-167.
5. Cattaneo M, Hayward CP, Moffat KA, et al. Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH. J Thromb Haemost 2009; 7: 1029.
6. Christie DJ, Avari T, Carrington LR, et al. Clinical and Laboratory Standards Institute (CLSI). Platelet function testing by aggregometry; approved guideline. CLSI document H58-A (ISBN 1-56238-683-2). Clinical and Laboratory Standards Institute, Wayne, PA, USA 2008; 28(31): available at: http://www.clsi.org. Assessed May 31, 2011.
7. Hayward CP, Moffat KA, Raby A, et al. Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. Am J Clin Pathol 2010; 134: 955-963.
8. Pai M, Hayward CP: Diagnostic assessment of platelet disorders: what are the challenges to standardization? Semin Thromb Hemost 2009; 35: 131-138.
9. Cattaneo M, Lecchi A, Zighetti ML, et al. Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. Haematologica 2007; 92: 694-697.
10. Mani H, Luxembourg B, Klaffling C, et al. Use of native or platelet count adjusted platelet rich plasma for platelet aggregation measurements. J Clin Pathol 2005; 58: 747-750.
11. Linnemann B, Schwonberg J, Mani H, et al. Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary. J Thromb Haemost 2008; 6: 677-683.
12. Favaloro EJ, Mohammed S. Platelet function testing: auditing local practice and broader implications. Clin Lab Sci 2010; 23: 21-31.
13. van der Stelt CA, van Werkum JW, Seesing TH, et al. To adjust or not to adjust the platelet count in light transmission aggregometry in patients receiving dual aspirin/ clopidogrel treatment. Platelets 2007; 18: 550-553.
14. Hayward CP, Moffat KA, Pai M, et al. An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts. Thromb Haemost 2008; 100: 134-145.
15. Pai M, Wang G, Moffat KA, et al. Diagnostic utility of a lumiaggregometer adenosine triphosphate release assay for the assessment of platelet function disorders. Am J Clin Pathol 2011; in press.
16. Paterson AD, Rommens JM, Bharaj B, et al. Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. Blood 11-2-2010; 115: 1264-1266.
17. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988; 44: 837-845.
18. Piaggio G, Elbourne DR, Altman DG, et al. Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement. J Am Med Assoc 2006; 295: 1152-1160.
19. Diamandis M, Veljkovic DK, Maurer-Spurej E, et al. Quebec platelet disorder: features, pathogenesis and treatment. Blood Coagul Fibrinolysis 2008; 19: 109-119.
20. Li CR, Liao CT, Liu JP: A non-inferiority test for diagnostic accuracy based on the paired partial areas under ROC curves. Stat Med 2008; 27: 1762-1776.
21. Mezzano D, Quiroga T, Pereira J: The level of laboratory testing required for diagnosis or exclusion of a platelet function disorder using platelet aggregation and secretion assays. Semin Thromb Hemost 2009; 35: 242-254.