Postoperative chemoradiation for resected gastric cancer - is the Macdonald Regimen Tolerable? A retrospective multi-institutional study

Radiation Oncology

Volumn 6, Issue 1, 2011, Pages

  Kundel, Yulia ^a   Purim, Ofer ^a   Idelevich, Efraim ^b   Lavrenkov, Konstantin ^c   Man, Sofia ^c   Kovel, Svetlana ^d   Karminsky, Natalia ^e   Pfeffer, Raphael M ^f   Nisenbaum, Bella ^g   Fenig, Eyal ^a   Sulkes, Aaron ^a   Brenner, Baruch ^a  

^a RABIN MEDICAL CENTER   (Israel)

^b KAPLAN MEDICAL CENTER   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d ASSAF HAROFEH MEDICAL CENTER   (Israel)

^e Wolfson Medical Center   (Israel)

^f TEL AVIV UNIVERSITY   (Israel)

^g MEIR MEDICAL CENTER   (Israel)

Author keywords

Israeli experience; Postoperative chemoradiation; Resected gastric cancer

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ABDOMINAL PAIN; ADULT; AGED; ANOREXIA; ARTICLE; CANCER RELAPSE; CANCER STAGING; CHEMORADIOTHERAPY; DIARRHEA; DISEASE FREE SURVIVAL; DRUG SAFETY; DRUG TOLERABILITY; ESOPHAGITIS; FATIGUE; FEMALE; FEVER; FOLLOW UP; GANGRENE; HUMAN; ISRAEL; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; OVERALL SURVIVAL; POSTOPERATIVE CARE; SEPSIS; SKIN DISEASE; STOMACH ADENOCARCINOMA; STOMATITIS; VOMITING; CLINICAL TRIAL; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; POSTOPERATIVE PERIOD; RETROSPECTIVE STUDY; STOMACH TUMOR; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; CHEMORADIOTHERAPY; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; HUMANS; LEUCOVORIN; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; TREATMENT OUTCOME;

EID: 80053175731     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-6-127     Document Type: Article

References (22)

1. Garcia M, Ward EM, Center MM, Hao Y, Siegel RL, Thun MJ. Global Cancer Facts & Figures. 2007, [online]. Accessed Aug 20, 2008., http://www.cancer.gov
2. Gunderson LL, Hoskins RB, Cohen AC, Kaufman S, Wood WC, Carey RW. Combined modality treatment of gastric cancer. Int J Radiat Oncol Biol Phys 1983, 9:965-975. 10.1016/0360-3016(83)90383-8, 6688072.
3. Landry J, Tepper JE, Wood WC, Moulton EO, Koerner F, Sullinger J. Patterns of failure following curative resection of gastric cancer. Int J Radiat Oncol Biol Phys 1990, 191:1357-1362.
4. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM, Martenson JA. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or Gastroesophageal junction. N Engl J Med 2001, 345:725-730. 10.1056/NEJMoa010187, 11547741.
5. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC Cancer Staging Manual 2010, 145-147. New York: Springer-Verlag, 7.
6. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J AM Stat Assoc 1958, 53:457-481.
7. Di Costanzo F, Gasperoni S, Manzione L, Bisagni G, Labianca R, Bravi S, Cortesi E, Carlini P, Bracci R, Tomao S, Messerini L, Arcangeli A, Torri V, Bilancia D, Floriani I, Tonato M, , Dinota A, Strafiuso G, Corgna E, Porrozzi S, Boni C, Rondini E, Giunta A, Monzio Compagnoni B, Biagioni F, Cesari M, Fornarini G, Nelli F, et al. Italian Oncology Group for Cancer Research Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase III trial conducted by GOIRC. J Natl Cancer Inst 2008, 100:388-398. 10.1093/jnci/djn054, 18334706, Italian Oncology Group for Cancer Research.
8. Oechsle K, Bokemeyer C, Hartmann JT, Budach W, Trarbach T, Stahl M, Boehlke I, Kollmannsberger C, . German AIO/ARO/CAO group Four consecutive multicenter phase 2 trials of adjuvant chemoradiation in patients with completely resected gastric cancer: the experience of the German AIO/ARO/CAO group. J Cancer Res Clin Oncol 2009, 135:163-172. 10.1007/s00432-008-0463-6, 18825411, German AIO/ARO/CAO group.
9. Kim S, Lim DH, Lee J, Kang WK, MacDonald JS, Park CH, Park SH, Lee SH, Kim K, Park JO, Kim WS, Jung CW, Park YS, Im YH, Sohn TS, Noh JH, Heo JS, Kim YI, Park CK, Park K. An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys 2005, 63:1279-1285. 10.1016/j.ijrobp.2005.05.005, 16099596.
10. Fuchs CS, Tepper JE, Niedzwiecki D, Hollis D, Mamon HJ, Swanson R, Haller DG, Dragovich T, Alberts SR, Bjarnason GA, Willett C, Enzinger PC, Goldberg RM, Venook AP, Mayer RJ. Postoperative adjuvant chemoradiation for gastric or gastroesophageal junction (GEJ) adenocarcinoma using epirubicin, cisplatin, and infusional (CI) 5-FU (ECF) before and after CI 5-FU and radiotherapy (CRT) compared with bolus 5-FU/LV before and after CRT: Intergroup trial CALGB 80101. J Clin Oncol 2011, 29(suppl):abstr 4003.
11. Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010, 376:687-697. 10.1016/S0140-6736(10)61121-X, 20728210.
12. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, . MAGIC Trial Participants Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006, 355:11-20. 10.1056/NEJMoa055531, 16822992, MAGIC Trial Participants.
13. Tsang WK, Leung SF, Chiu SK, Yeung WW, Ng EK, Yeo W, Lam KC, Chiu PW, Ma BB, Kwan WH, Chan AT. Adjuvat chemoradiation for gastric cancer: experience in the Chinese population. Clin Oncol (R Coll Radiol) 2007, 19:333-340.
14. Hughes BG, Yip D, Chao M, Gibbs P, Carroll S, Goldstein D, Burmeister B, Karapetis C. Audit of postoperative chemoradiotherapy as adjuvant therapy for resected gastroesophageal adenocarcinoma: an Australian multicentre experience. ANZ J Surg 2004, 74:951-956. 10.1111/j.1445-1433.2004.03218.x, 15550081.
15. Kassam Z, Lockwood G, O'brien C, Brierley J, Swallow C, Oza A, Siu L, Knox JJ, Wong R, Cummings B, Kim J, Moore M, Ringash J. Conformal radiotherapy in adjuvant treatment of gastric cancer: review of 82 cases. Int J Radiat Oncol Biol Phys 2006, 65:713-19. 10.1016/j.ijrobp.2006.01.001, 16626887.
16. Hofheinz RD, Wenz F, Lukan N, Mai S, Kripp M, Staiger W, Schwarzbach M, Willeke F, Möhler M, Post S, Hochhaus A. Oxaliplatin and capecitabine-based chemoradiotherapy for gastric cancer--an extended phase I MARGIT and AIO trial. Int Oncol Biol Phys 2009, 73:142-147.
17. Chang AT, Ng WT, Law AL, Ku KM, Lee MC, Lee AW. Adjuvant chemoradiation for resected gastric cancer: 10-year experience. Gastric Cancer 2011, 14:63-71. 10.1007/s10120-011-0011-y, 21327926.
18. Park SH, Kim DY, Heo JS, Lim DH, Park CK, Lee KW, Choi SH, Sohn TS, Kim S, Noh JH, Kim YI, Park JO, Kim K, Kim WS, Jung CW, Im YH, Lee MH, Park K, Park CH, Kang WK. Postoperative chemoradiotherapy for gastric cancer. Ann Oncol 2003, 14:1373-1377. 10.1093/annonc/mdg366, 12954575.
19. Lee HS, Choi Y, Hur WJ, Kim HJ, Kwon HC, Kim SH, Kim JS, Lee JH, Jung GJ, Kim MC. Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: adjuvant 5-FU/cisplatin and chemoradiation with capecitabine. World J Gastroenterol 2006, 28:603-607.
20. Kollmannsberger C, Budach W, Stahl M, Schleucher N, Hehr T, Wilke H, Schleicher J, Vanhoefer U, Jehle EC, Oechsle K, Trarbach T, Boehlke I, Kanz L, Hartmann JT, Bokemeyer C. Adjuvant chemoradiation using 5-fluorouracil/folinic acid/cisplatin with or without paclitaxel and radiation in patients with completely resected high-risk gastric cancer: two cooperative phase II studies of the AIO/ARO/ACO. Ann Oncol 2005, 16:1326-1333. 10.1093/annonc/mdi252, 15919686.
21. Aftimos PG, Nasr EA, Nasr DI, Noun RJ, Nasr FL, Ghosn MG, El Helou JA, Chahine GY. Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience. Radiat Oncol 2010, 5:50. 10.1186/1748-717X-5-50, 2887890, 20525367.
22. Leong T, Joon DL, Willis D. Adjuvant chemoradiation for gastric cancer using epirubicin, cisplatin and 5-flourouracil before and after three dimensional conformal radiotherapy with concurrent infusional 5-fluorouracil a multicenter study of the Trans-Tasman Radiation Oncology Group. Int J Radiat Oncol Biol Phys 2011, 79:690-5. Epub 2010 May 14, 10.1016/j.ijrobp.2009.11.042, 20472363.