Slow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion

Journal of Biomedical Science

Volumn 18, Issue 1, 2011, Pages

  Lai, Yu Jun ^a   Hung, Chung Lieh ^a   Hong, Ray Ching ^a   Tseng, Ya Ming ^a   Lin, Cheng I ^b   Ko, Yu Shien ^c   Tsai, Cheng Ho ^a   Yeh, Hung I ^a  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

alcohol; arrhythmia; gap junctions; optical mapping; remodeling

Indexed keywords

CONNEXIN 43; ALCOHOL;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SIZE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; GAP JUNCTION; HEART ELECTROPHYSIOLOGY; HEART VENTRICLE TACHYCARDIA; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL JUNCTION; CHEMICALLY INDUCED DISORDER; DRINKING BEHAVIOR; DRUG EFFECT; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

MURINAE; MUS;

ALCOHOL DRINKING; ANIMALS; ARRHYTHMIAS, CARDIAC; CONNEXIN 43; ETHANOL; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC;

EID: 80053174401     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-18-72     Document Type: Article

References (29)

1. Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Lang CH, Frost RA, Summer AD, Vary TC, Int J Biochem Cell Biol 2005 37 2180 2195 10.1016/j.biocel.2005.04.013 15982919 (Pubitemid 41206830)
2. Alcoholic cardiomyopathy: is it dose-dependent? Lee WK, Regan TJ, Congest Heart Fail 2002 8 303 306 10.1111/j.1527-5299.2002.00282.x 12461319
3. The effects of alcohol on the heart. Patel VB, Why HJ, Richardson PJ, Preedy VR, Adverse Drug React Toxicol Rev 1997 16 15 43 9192055 (Pubitemid 27230650)
4. Alcoholic cardiomyopathy. Iacovoni A, De Maria R, Gavazzi A, J Cardiovasc Med (Hagerstown) 2010 11 884 892 10.2459/JCM.0b013e32833833a3
5. Altered intracardiac conduction after acute administration of ethanol in the dog. Goodkind MJ, Gerber NH, Mellen JR, Kostis JB, J Pharmacol Exp Ther 1975 194 633 638 1159636
6. Alcohol, cardiac arrhythmias and sudden death. Kupari M, Koskinen P, Novartis Found Symp 1998 216 68 79 discussion 79-85 9949788
7. Electrophysiological effects of ethanol, acetaldehyde, and acetate on cardiac tissues from dog and guinea pig. Williams ES, Mirro MJ, Bailey JC, Circ Res 1980 47 473 478 7408127 (Pubitemid 10001096)
8. Connexins in mammalian heart function. Gros DB, Jongsma HJ, Bioessays 1996 18 719 730 10.1002/bies.950180907 8831288 (Pubitemid 26351964)
9. Gap junction alterations in human cardiac disease. Severs NJ, Coppen SR, Dupont E, Yeh HI, Ko YS, Matsushita T, Cardiovasc Res 2004 62 368 377 10.1016/j.cardiores.2003.12.007 15094356 (Pubitemid 38496549)
10. Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Gutstein DE, Morley GE, Vaidya D, Liu F, Chen FL, Stuhlmann H, Fishman GI, Circulation 2001 104 1194 1199 10.1161/hc3601.093990 11535579 (Pubitemid 32830407)
11. Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice. Lerner DL, Yamada KA, Schuessler RB, Saffitz JE, Circulation 2000 101 547 552 10662753 (Pubitemid 30080870)
12. Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC, Physiol Behav 2005 84 53 63 10.1016/j.physbeh.2004.10.007 15642607 (Pubitemid 40092065)
13. Alcoholic cardiomyopathy: incidence, clinical characteristics, and pathophysiology. Piano MR, Chest 2002 121 1638 1650 10.1378/chest.121.5.1638 12006456 (Pubitemid 34499683)
14. Left ventricular size, mass and function in relation to the duration and quantity of heavy drinking in alcoholics. Kupari M, Koskinen P, Suokas A, Am J Cardiol 1991 67 274 279 10.1016/0002-9149(91)90559-4 1825010
15. Early changes in left ventricular function in chronic asymptomatic alcoholics: relation to the duration of heavy drinking. Lazarevic AM, Nakatani S, Neskovic AN, Marinkovic J, Yasumura Y, Stojicic D, Miyatake K, Bojic M, Popovic AD, J Am Coll Cardiol 2000 35 1599 1606 10.1016/S0735-1097(00)00565-9 10807466 (Pubitemid 30307506)
16. Alcohol consumption and heart failure. Urbano-Marquez A, Fernandez-Sola J, J Card Fail 2005 11 329 332 10.1016/j.cardfail.2005.04.023 15948081
17. The effects of alcoholism on skeletal and cardiac muscle. Urbano-Marquez A, Estruch R, Navarro-Lopez F, Grau JM, Mont L, Rubin E, N Engl J Med 1989 320 409 415 10.1056/NEJM198902163200701 2913506 (Pubitemid 19059272)
18. Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation. Wang L, Zhou Z, Saari JT, Kang YJ, Am J Pathol 2005 167 337 344 10.1016/S0002-9440(10)62979-3 16049321 (Pubitemid 43026091)
19. Protein metabolism in alcoholism: effects on specific tissues and the whole body. Preedy VR, Reilly ME, Patel VB, Richardson PJ, Peters TJ, Nutrition 1999 15 604 608 10.1016/S0899-9007(99)00096-9 10422097 (Pubitemid 29340046)
20. Morphometric analysis of the rabbit myocardium after chronic ethanol feeding-early capillary changes. Mall G, Mattfeldt T, Rieger P, Volk B, Frolov VA, Basic Res Cardiol 1982 77 57 67 10.1007/BF01908131 7073653 (Pubitemid 12184485)
21. Alcoholic cardiomyopathy and sudden cardiac death. Vikhert AM, Tsiplenkova VG, Cherpachenko NM, J Am Coll Cardiol 1986 8 3A 11A 10.1016/S0735-1097(86)80023-7 3711541 (Pubitemid 16064072)
22. Moderate levels of ethanol induce expression of vascular endothelial growth factor and stimulate angiogenesis. Gu JW, Elam J, Sartin A, Li W, Roach R, Adair TH, Am J Physiol Regul Integr Comp Physiol 2001 281 365 372 11404314
23. Effect of chronic ethanol ingestion and gender on heart left ventricular p53 gene expression. Jankala H, Eriksson PC, Eklund K, Sarviharju M, Harkonen M, Maki T, Alcohol Clin Exp Res 2005 29 1368 1373 10.1097/01.alc.0000175043.67463. e5 16131843 (Pubitemid 41243360)
24. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome. Teodoro JG, Evans SK, Green MR, J Mol Med 2007 85 1175 1186 10.1007/s00109-007-0221-2 17589818 (Pubitemid 47622219)
25. Altering the topology of gap junctions a major therapeutic target for atrial fibrillation. Spach MS, Starmer CF, Cardiovasc Res 1995 30 337 344 10.1016/0008-6363(96)88514-2 7585823
26. The molecular basis of anisotropy: role of gap junctions. Saffitz JE, Davis LM, Darrow BJ, Kanter HL, Laing JG, Beyer EC, J Cardiovasc Electrophysiol 1995 6 498 510 10.1111/j.1540-8167.1995.tb00423.x 7551319
27. Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. Spach MS, Heidlage JF, Dolber PC, Barr RC, Circulation Research 2000 86 302 311 10679482 (Pubitemid 30108824)
28. Differential expression of connexin43 gap junctions in cardiomyocytes isolated from canine thoracic veins. Yeh HI, Lai YJ, Lee YN, Chen YJ, Chen YC, Chen CC, Chen SA, Lin CI, Tsai CH, J Histochem Cytochem 2003 51 259 266 10.1177/002215540305100215 12533535 (Pubitemid 36160052)
29. Adenoviral gene transfer with soluble vascular endothelial growth factor receptors impairs angiogenesis and perfusion in a murine model of hindlimb ischemia. Jacobi J, Tam BY, Wu G, Hoffman J, Cooke JP, Kuo CJ, Circulation 2004 110 2424 2429 10.1161/01.CIR.0000145142.85645.EA 15477417 (Pubitemid 39407349)