Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Chu, Sheng Hua ^a   Feng, Dong Fu ^a   Ma, Yan Bin ^a   Zhang, Hong ^a   Zhu, Zhi An ^a   Li, Zhi Qiang ^b   Jiang, Pu Cha ^b  

^a School of Medicine   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC CATION TRANSPORTER; SOLUTE CARRIER FAMILY 22 MEMBER 18 PROTEIN; UNCLASSIFIED DRUG; AZACITIDINE; MESSENGER RNA; SLC22A18 PROTEIN, HUMAN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CANCER CELL DESTRUCTION; CANCER GROWTH; CANCER RECURRENCE; CARCINOGENESIS; CELL ADHESION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GLIOMA; GLIOMA CELL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; POLYMERASE CHAIN REACTION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; TUMOR XENOGRAFT; ANIMAL; BRAIN; CANCER GRADING; CELL DEATH; DISEASE COURSE; DNA METHYLATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PROMOTER REGION; RECURRENT DISEASE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; AZACITIDINE; BLOTTING, WESTERN; BRAIN; CELL ADHESION; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DNA METHYLATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MICE; NEOPLASM GRADING; NEURONS; OLIGODENDROGLIA; ORGANIC CATION TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RECURRENCE; RNA, MESSENGER;

EID: 80053171905     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-156     Document Type: Article

References (27)

1. Chu SH, Feng DF, Zhang H, Chen ET, Duan ZX, Li XY, Li J, Ma YB, Zhu ZA, Qiu JH. c-Met-targeted RNA interference inhibits growth and metastasis of glioma U251 cells in vitro. J Neurooncol 2009, 93:183-9. 10.1007/s11060-008-9772-5, 19165419.
2. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 2008, 455:1129-33. 10.1038/nature07443, 18948956.
3. Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest 2006, 86:1221-32. 10.1038/labinvest.3700482, 17075581.
4. Chu SH, Ma YB, Feng DF, Zhang H, Qiu JH, Zhu ZA. c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel. Oncol Rep 2010, 24:189-94.
5. D Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu RJ, Brandenburg S, Lee MJ, Miller G, Feinberg AP. Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5. Cancer Res 1998, 58:4155-9.
6. Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. Proc Natl Acad Sci USA 1998, 95:3873-8. 10.1073/pnas.95.7.3873, 19930, 9520460.
7. Yamada HY, Gorbsky GJ. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Oncogene 2006, 25:1330-9. 10.1038/sj.onc.1209167, 2713668, 16314844.
8. Albrecht S, Hartmann W, Houshdaran F, Koch A, Gärtner B, Prawitt D, Zabel BU, Russo P, Von Schweinitz D, Pietsch T. Allelic loss but absence of mutations in the polyspecific transporter gene BWR1A on 11p15.5 in hepatoblastoma. Int J Cancer 2004, 111:627-32. 10.1002/ijc.20280, 15239143.
9. Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C. Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development 2010, 137:2493-2499. 10.1242/dev.048181, 20573698.
10. Gallagher E, Mc Goldrick A, Chung WY, Mc Cormack O, Harrison M, Kerin M, Dervan PA, Mc Cann A. Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer. Genomics 2006, 88:12-7. 10.1016/j.ygeno.2006.02.004, 16624517.
11. Wang S, Liu H, Ren L, Pan Y, Zhang Y. Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference. Neoplasia 2008, 10:399-407. 2288544, 18392139.
12. Wang S, Liu H, Ren L, Pan Y, Zhang Y. Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference. Neoplasia 2008, 10:399-407. 2288544, 18392139.
13. Uemura K, Takao S, Aikou T. In vitro determination of basement membrane invasion predicts liver metastases in human gastrointestinal carcinoma. Cancer Res 1998, 58:3727-31.
14. Jin M, He S, Wörpel V, Ryan SJ, Hinton DR. Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-alpha. Invest Ophthalmol Vis Sci 2000, 41:4324-32.
15. Wang SM, Zhu J, Pan LF, Liu YK. Inhibitory effect of dimeric β peptide on the recurrence and metastasis of hepatocellular carcinoma in vitro and in mice. World J Gastroenterol 2008, 14:3054-8. 10.3748/wjg.14.3054, 2712174, 18494058.
16. Xu HM, Zhang HW, He HY, Hou YY, Zhao ZQ. Methylation and mRNA expression of imprinted gene SLC22A18/TSSC5/BWR1A in breast cancer (in Chinese). Chin J Pathophysiol 2008, 24:1007-12.
17. Chu SH, Yuan XH, Li ZQ, Jiang PC, Zhang J. C-Met antisense oligodeoxynucleotide inhibits growth of glioma cells. Surg Neurol 2006, 65:533-538. 10.1016/j.surneu.2005.11.024, 16720163.
18. Gutmann DH, Huang ZY, Hedrick NM, Ding H, Guha A, Watson MA. Mouse glioma gene expression profiling identifies novel human glioma-associated genes. Ann Neurol 2002, 51:393-405. 10.1002/ana.10145, 11891838.
19. Dong Y, Jia L, Wang X, Tan X, Xu J, Deng Z, Jiang T, Rainov NG, Li B, Ren H. Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells. Int J Oncol 2011, 38:555-69.
20. Hu J, Jiang C, Ng HK, Pang JC, Tong CY, Chen S. Genome-wide allelotype study of primary glioblastoma multiforme. Chin Med J (Engl) 2003, 116:577-83.
21. Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell 2010, 18:619-29. 10.1016/j.ccr.2010.10.034, 21156285.
22. Noble M, Mayer-Pröschel M. Growth factors, glia and gliomas. J Neurooncol 1997, 35:193-209. 10.1023/A:1005898228116, 9440020.
23. Holland EC, Hively WP, DePinho RA, Varmus HE. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 1998, 12:3675-85. 10.1101/gad.12.23.3675, 317252, 9851974.
24. Liu C, Sage JC, Miller MR, Verhaak RG, Hippenmeyer S, Vogel H, Foreman O, Bronson RT, Nishiyama A, Luo L, Zong H. Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma. Cell 2011, 146:209-21. 10.1016/j.cell.2011.06.014, 21737130.
25. Li Y, Meng G, Guo QN. Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. Exp Mol Pathol 2008, 84:234-239. 10.1016/j.yexmp.2008.03.013, 18501891.
26. Bajaj V, Singhmar P, Kumar A. Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. Gene 2008, 424:40-47. 10.1016/j.gene.2008.07.032, 18721868.
27. Ali AM, Bajaj V, Gopinath KS, Kumar A. Characterization of the human SLC22A18 gene promoter and its regulation by the transcription factor Sp1. Gene 2009, 429:37-43. 10.1016/j.gene.2008.10.004, 18996451.