Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy

Oncology Reports

Volumn 26, Issue 5, 2011, Pages 1069-1074

  Saigusa, Susumu ^a   Mohri, Yasuhiko ^a   Masaki, O H I ^a   Toiyama, Yuji ^a   Ishino, Yoshito ^a   Okugawa, Yoshinaga ^a   Tanaka, Koji ^a   Inoue, Yasuhiro ^a   Kusunoki, Masato ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Esophageal squamous cell carcinoma; Neoadjuvant chemo radiotherapy; Podoplanin; SOX2

Indexed keywords

CISPLATIN; FLUOROURACIL; PODOPLANIN; TRANSCRIPTION FACTOR SOX2; UFT;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER INVASION; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MULTIPLE CYCLE TREATMENT; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY, ADJUVANT; CISPLATIN; ESOPHAGEAL NEOPLASMS; FEMALE; FLUOROURACIL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; NEOADJUVANT THERAPY; NEOPLASM STAGING; SOXB1 TRANSCRIPTION FACTORS; SURVIVAL ANALYSIS;

EID: 80053168039     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1408     Document Type: Article

References (27)

1. Vizcaino AP, Moreno V, Lambert R, et al: Time trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973-1995. Int J Cancer 99: 860-868, 2002. (Pubitemid 34575705)
2. Lv J, Cao XF, Zhu B, et al: Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma. World J Gastroenterol 15: 4962-4968, 2009.
3. Stahl M, Stuschke M, Lehmann N, et al: Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 23: 2310-2317, 2005. (Pubitemid 46218723)
4. Bedenne L, Michel P, Bouche O, et al: Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 25: 1160-1168, 2007. (Pubitemid 46640561)
5. Gebski V, Burmeister B, Smithers BM, et al: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncol 8: 226-234, 2007. (Pubitemid 46291702)
6. Reya T, Morrison SJ, Clarke MF, et al: Stem cells, cancer, and cancer stem cells. Nature 414: 105-111, 2001. (Pubitemid 33041634)
7. Vermeulen L, Sprick MR, Kemper K, et al: Cancer stem cells-old concepts, new insights. Cell Death Differ 15: 947-958, 2008. (Pubitemid 351712600)
8. Atsumi N, Ishii G, Kojima M, et al: Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431. Biochem Biophys Res Commun 373: 36-41, 2008.
9. Rahadiani N, Ikeda J, Makino T, et al: Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma. Ann Surg Oncol 17: 1311-1323, 2010.
10. Raica M, Cimpean AM and Ribatti D: The role of podoplanin in tumor progression and metastasis. Anticancer Res 28: 2997-3006, 2008.
11. Kreppel M, Scheer M, Drebber U, et al: Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations. Virchows Arch 456: 473-482, 2010.
12. Rodrigo JP, Garcia-Carracedo D, Gonzalez MV, et al: Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas. Mol Cancer 9: 48, 2010.
13. Long KB and Hornick JL: SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol 40: 1768-1773, 2009.
14. Wicki A, Lehembre F, Wick N, et al: Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 9: 261-272, 2006.
15. Cueni LN, Hegyi I, Shin JW, et al: Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol 177: 1004-1016, 2010.
16. Schacht V, Ramirez MI, Hong YK, et al: T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 22: 3546-3556, 2003. (Pubitemid 36898332)
17. Sleeman JP and Thiele W: Tumor metastasis and the lymphatic vasculature. Int J Cancer 125: 2747-2756, 2009.
18. Yamanaka S: Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1: 39-49, 2007.
19. Bass AJ, Watanabe H, Mermel CH, et al: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 41: 1238-1242, 2009.
20. Que J, Okubo T, Goldenring JR, et al: Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134: 2521-2531, 2007. (Pubitemid 47074146)
21. Mandard AM, Dalibard F, Mandard JC, et al: Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer 73: 2680-2686, 1994. (Pubitemid 24166250)
22. Kassouf W, Agarwal PK, Herr HW, et al: Lymph node density is superior to TNM nodal status in predicting disease-specific survival after radical cystectomy for bladder cancer: analysis of pooled data from MDACC and MSKCC. J Clin Oncol 26: 121-126, 2008.
23. McMillan DC, Crozier JE, Canna K, et al: Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. Int J Colorectal Dis 22: 881-886, 2007. (Pubitemid 46952036)
24. Shimada Y, Ishii G, Nagai K, et al: Expression of podoplanin, CD44, and p63 in squamous cell carcinoma of the lung. Cancer Sci 100: 2054-2059, 2009.
25. Kyzas PA, Geleff S, Batistatou A, et al: Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol 206: 170-177, 2005. (Pubitemid 40754020)
26. Longatto Filho A, Oliveira TG, Pinheiro C, et al: How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis? World J Surg Oncol 5: 140, 2007.
27. Debald M, Polcher M, Flucke U, et al: Increased detection of lymphatic vessel invasion by D2-40 (podoplanin) in early breast cancer: possible influence on patient selection for accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 77: 1128-1133, 2010.