Effects of 4-nonylphenol on proliferation of AGS gastric cells

Cell Proliferation

Volumn 44, Issue 5, 2011, Pages 477-485

  Manente, L ^a   Sellitti, A ^b   Lucariello, A ^a   Laforgia, V ^b   de Falco, M ^b   de Luca, A ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 NONYLPHENOL; CASPASE 3; CASPASE 8; CASPASE 9; FAS ANTIGEN; FAS LIGAND; LIPOCORTIN 5; PROTEIN P21; PROTEIN P27;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN INDUCTION; STOMACH EPITHELIUM;

ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CELL CYCLE; CELL LINE; CELL PROLIFERATION; ENDOCRINE DISRUPTORS; EPITHELIAL CELLS; FAS LIGAND PROTEIN; FOOD CONTAMINATION; GASTRIC MUCOSA; HUMANS; PHENOLS; RETINOBLASTOMA PROTEIN;

EID: 80053164234     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2011.00774.x     Document Type: Article

References (29)

1. U.S. Environmental Protection Agency (2000) Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC). Washington, DC: U.S. Environmental Protection Agency. Available at (accessed 14 September 2006).
2. Brotons JA, Olea Serrano MF, Villalobos M, Pedraza V, Olea N (1995) Xenoestrogens released from lacquer coatings in food cans. Environ. Health Perspect. 103, 608-612.
3. Ying GG, Williams B, Kookana R (2002) Environmental fate of alkylphenols and alkylphenol ethoxylates - a review. Environ. Int. 28, 215-226. review.
4. Tsuda T, Suga K, Kaneda E, Ohsuga MJ (2000) Determination of 4-nonylphenol, nonylphenol monoethoxylate, nonylphenol diethoxylate and other alkylphenols in fish and shellfish by high-performance liquid chromatography with fluorescence detection. Chromatogr. B Biomed. Sci. Appl. 15, 305-309.
5. Junk GA, Richard JJ, Grieser MD, Witiak D, Witiak JL, Arguello MD et al. (1974) Use of macroreticular resins in the analysis of water for trace organic contaminants. J. Chromatogr. 99, 745-762.
6. Clark LB, Rosen RT, Hartman TG, Louis JB, Suffet IH, Lippincott RL (1992) Determination of alkylphenol ethoxylates and their acetic acid derivatives in drinking water by particle beam liquid chromatography/electrospray mass spectrometry. Int. J. Environ. Anal. Chem. 47, 167-180.
7. Soto AM, Justicia H, Wray JW, Sonnenschein C (1991) "p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene". Biol. Reprod. 52, 217-225.
8. Guenther K, Heinke V, Thiele B, Kleist E, Prast H, Raecker T (2003) Endocrine disrupting nonylphenols are ubiquitous in food. Environ. Sci. Technol. 37, 2622-2623.
9. Monteiro-Riviere NA, Van Miller JP, Simon G, Joiner RL, Brooks JD, Riviere JE (2000) Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin. Toxicol. Ind. Health 16, 49-57.
10. Rankouhi TR, Sanderson JT, van Holsteijn I, van Leeuwen C, Vethaak AD, van den Berg M (2004) Effects of natural and synthetic estrogens and various environmental contaminants on vitellogenesis in fish primary hepatocytes: comparison of bream (Abramis brama) and carp (Cyprinus carpio). Toxicol. Sci. 81, 90-102.
11. Sweeney T (2002) Is exposure to endocrine disrupting compounds during fetal/post-natal development affecting the reproductive potential of farm animals? Domest. Anim. Endocrinol. J. 23, 203-209.
12. Wang X, Han X, Hou Y, Yao G, Wang Y (2003) Effect of nonylphenol on apoptosis of Sertoli cell in vitro. Bull. Environ. Contam. Toxicol. 70, 898-904.
13. Andree HA, Reutelingsperger CP, Hauptmann R, Hemker HC, Hermens WT, Willems GM (1990) Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers. J. Biol. Chem. 265, 4923-4928.
14. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184, 39-51.
15. Manente L, Perna A, Buommino E, Altucci L, Lucariello A, Citro G et al. (2008) The Helicobacter pylori's Protein VacA has direct effects on the regulation of cell cycle and apoptosis in gastric epithelial cells. J. Cell. Physiol. 214, 582-587.
16. Laws SC, Carey SA, Ferrell JM, Bodman GJ, Cooper RL (2000) Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol. Sci. 54, 154-167.
17. Odum J, Pyrah IT, Foster JR, Van Miller JP, Joiner RL, Ashby J (1999) Comparative activities of p-nonylphenol and diethylstilbestrol in noble rat mammary gland and uterotrophic assays. Regul. Toxicol. Pharmacol. 29, 184-195.
18. Ashfield LA, Pottinger TG, Sumpter JP (1998) Exposure of female juvenile rainbow trout to alkylphenolic compounds results in modifications to growth and ovosomatic index. Environ. Toxicol. Chem. 17, 679-686.
19. Chapin RE, Delaney J, Wang Y, Lanning L, Davis B, Collins B et al. (1999) The effects of 4-noylphenol in rats: a multigeneration reproduction study. Toxicol. Sci. 52, 80-91.
20. Nagao T, Wada K, Marumo H, Yoshimura S, Ono H (2001) Reproductive effects of nonylphenol in rats after gavage administration: a two-generation study. Reprod. Toxicol. 15, 293-315.
21. El Deiry W, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J et al. (1994) WAF1/CIP1 is induced in p53-mediated G1. Cancer Res. 54, 1169-1174.
22. Michieli P, Chedid M, Lin D, Pierce HJ, Mercer WE, Givol D (1994) Induction of Waf1/Cip1 by a p53-independent pathway. Cancer Res. 54, 3391-3395.
23. Ping Dou Q, Bing An (1998) Rb and apoptotic cell death. Front Biosci. 3, 419-430.
24. Kudo C, Wada K, Masuda T, Yonemura T, Shibuya A, Fujimoto Y et al. (2004) Nonylphenol induces the death of neural stem cells due to activation of the caspase cascade and regulation of the cell cycle. J. Neurochem. 88, 1416-1423.
25. Thorburn A (2004) Death receptor-induced cell killing. Cell. Signal. 16, 139-144.
26. Yao G, Hu Y, Liang J, Hou Y (2005) Nonylphenol-induced thymocyte apoptosis is related to Fas/FasL pathway. Life Sci. 12, 3306-3320.
27. Han XD, Tu ZG, Gong Y, Shen SN, Wang XY, Kang LN et al. (2004) The toxic effects of the nonylphenol on the reproductive system of male rats. Reprod. Toxicol. 19, 215-221.
28. Paris F, Balaguer P, Terouanne B, Servant N, Lacoste C, Cravedi JP et al. (2002) Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell lines. Mol. Cell. Endocrinol. 193, 43-49.
29. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG (1994) Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.