Thromboxane prostanoid receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 1, 2011, Pages 248-256

  Hernandez, Jeremy Mark ^a   Janssen, Luke Jeffrey ^a  

^a ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11 FLUORO 9,15 DIHYDROXY 15 (2 INDANYL) 16,17,18,19,20 PENTANORPROSTA 5,13 DIENOIC ACID; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 6 [2 (2 CHLOROPHENYL) 4 (2 HYDROXYPHENYL) 1,3 DIOXAN 5 YL] 4 HEXENOIC ACID; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; 9ALPHA DIHYDROXY 11BETA FLUORO 15 (2,3 DIHYDRO 1H INDEN 2 YL) 16,17,18,19,20 PENTANORPROSTADIEN 1 OIC ACID; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PD 95089; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTANOID RECEPTOR; THROMBOXANE A2; THROMBOXANE RECEPTOR; THROMBOXANE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; BRONCHUS; BRONCHUS MUSCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; LUNG RECEPTOR; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

ACETYLCHOLINE; AIR PRESSURE; ANIMALS; BRONCHI; CATTLE; CYCLOOXYGENASE INHIBITORS; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; IMMUNOENZYME TECHNIQUES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLE CONTRACTION; MUSCLE SPINDLES; MUSCLE TONUS; PROSTAGLANDIN D2; RECEPTORS, THROMBOXANE; RESPIRATORY MUCOSA; RESPIRATORY MUSCLES; THROMBOXANE A2;

EID: 80053147733     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.182246     Document Type: Article

References (39)

1. Allen IC, Hartney JM, Coffman TM, Penn RB, Wess J, and Koller BH (2006) Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 290:L526-L533. (Pubitemid 43725097)
2. An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, et al. (2007) Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 29:834-860. (Pubitemid 46722226)
3. Ansell TK, McFawn PK, Noble PB, West AR, Fernandes L, and Mitchell HW (2009) Potent bronchodilation and reduced stiffness by relaxant stimuli under dynamic conditions. Eur Respir J 33:844-851.
4. Barnes PJ (2001) Neurogenic inflammation in the airways. Respir Physiol 125: 145-154.
5. Barnes PJ, Chung KF, and Page CP (1998) Inflammatory mediators of asthma: an update. Pharmacol Rev 50:515-596. (Pubitemid 29028812)
6. Bertolini A, Ottani A, and Sandrini M (2001) Dual acting anti-inflammatory drugs: a reappraisal. Pharmacol Res 44:437-450. (Pubitemid 34014322)
7. Coleman RA, Kennedy I, and Sheldrick RL (1987) New evidence with selective agonists and antagonists for the subclassification of PGE2-sensitive (EP) receptors. Adv Prostaglandin Thromboxane Leukot Res 17A:467-470.
8. Copland IB, Reynaud D, Pace-Asciak C, and Post M (2006) Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 291:L487-L495. (Pubitemid 44343726)
9. Devillier P and Bessard G (1997) Thromboxane A2 and related prostaglandins in airways. Fundam Clin Pharmacol 11:2-18.
10. Dogné JM, De Leval X, Benoit P, Rolin S, Pirotte B, and Masereel B (2002) Therapeutic potential of thromboxane inhibitors in asthma. Expert Opin Investig Drugs 11:275-281. (Pubitemid 34144870)
11. Duan W and Wong WS (2006) Targeting mitogen-activated protein kinases for asthma. Curr Drug Targets 7:691-698. (Pubitemid 43827265)
12. Gayrard P, Orehek J, Grimaud C, and Charpin J (1975) Bronchoconstrictor effects of a deep inspiration in patients with asthma. Am Rev Respir Dis 111:433-439.
13. Gunst SJ and Russell JA (1982) Contractile force of canine tracheal smooth muscle during continuous stretch. J Appl Physiol 52:655-663. (Pubitemid 12041110)
14. Gunst SJ, Stropp JQ, and Service J (1990) Mechanical modulation of pressurevolume characteristics of contracted canine airways in vitro. J Appl Physiol 68: 2223-2229. (Pubitemid 20183120)
15. Hernandez JM, Cox G, and Janssen LJ (2008) Involvement of the neurokinin-2 receptor in airway smooth muscle stretch-activated contractions assessed in perfused intact bovine bronchial segments. J Pharmacol Exp Ther 327:503-510.
16. Holtzman MJ (1992) Arachidonic acid metabolism in airway epithelial cells. Annu Rev Physiol 54:303-329.
17. Jabbour HN, Sales KJ, Boddy SC, Anderson RA, and Williams AR (2005) A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2α synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway. Endocrinology 146:4657-4664. (Pubitemid 41446603)
18. Jackson AC, Murphy MM, Rassulo J, Celli BR, and Ingram RH Jr (2004) Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects. J Appl Physiol 96:137-142. (Pubitemid 38031993)
19. Janssen LJ and Daniel EE (1991) Pre- and postjunctional effects of a thromboxane mimetic in canine bronchi. Am J Physiol Lung Cell Mol Physiol 261:L271-L276.
20. Janssen LJ and Tazzeo T (2002) Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J Pharmacol Exp Ther 301:1060-1066. (Pubitemid 34595098)
21. Kinsella BT (2001) Thromboxane A2 signalling in humans: a 'Tail' of two receptors. Biochem Soc Trans 29:641-654.
22. LaPrad AS, Szabo TL, Suki B, and Lutchen KR (2010) Tidal stretches do not modulate responsiveness of intact airways in vitro. J Appl Physiol 109:295-304.
23. Lei Y, Cao Y, Zhang Y, Edvinsson L, and Xu CB (2011) Enhanced airway smooth muscle cell thromboxane receptor signaling via activation of JNK MAPK and extracellular calcium influx. Eur J Pharmacol 650:629-638.
24. Lim TK, Pride NB, and Ingram RH Jr (1987) Effects of volume history during spontaneous and acutely induced air-flow obstruction in asthma. Am Rev Respir Dis 135:591-596. (Pubitemid 17041589)
25. Maksym GN, Deng L, Fairbank NJ, Lall CA, and Connolly SC (2005) Beneficial and harmful effects of oscillatory mechanical strain on airway smooth muscle. Can J Physiol Pharmacol 83:913-922. (Pubitemid 43235416)
26. Mitchell HW, Willet KE, and Sparrow MP (1989) Perfused bronchial segment and bronchial strip: narrowing vs. isometric force by mediators. J Appl Physiol 66: 2704-2709. (Pubitemid 19164972)
27. Mitchell RW, Rabe KF, Magnussen H, and Leff AR (1997) Passive sensitization of human airways induces myogenic contractile responses in vitro. J Appl Physiol 83:1276-1281. (Pubitemid 27433096)
28. Noble PB, Hernandez JM, Mitchell HW, and Janssen LJ (2010) Deep inspiration and airway physiology: human, canine, porcine, or bovine? J Appl Physiol 109:938-939; author reply 940-941.
29. Noble PB, McFawn PK, and Mitchell HW (2007) Responsiveness of the isolated airway during simulated deep inspirations: effect of airway smooth muscle stiffness and strain. J Appl Physiol 103:787-795. (Pubitemid 47358859)
30. Orehek J, Douglas JS, and Bouhuys A (1975) Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs. J Pharmacol Exp Ther 194:554-564.
31. Robinson C, Hardy CC, and Holgate ST (1985) Pulmonary synthesis, release, and metabolism of prostaglandins. J Allergy Clin Immunol 76:265-271. (Pubitemid 16247816)
32. Robinson C, Hoult JR, Waddell KA, Blair IA, and Dollery CT (1984) Total profiling by GC/NICIMS of the major cyclo-oxygenase products from antigen and leukotriene-challenged guinea-pig lung. Biochem Pharmacol 33:395-400. (Pubitemid 14163159)
33. Russell JA (1978) Responses of isolated canine airways to electric stimulation and acetylcholine. J Appl Physiol 45:690-698.
34. Salome CM, Thorpe CW, Diba C, Brown NJ, Berend N, and King GG (2003) Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects. Eur Respir J 22:62-68. (Pubitemid 36896472)
35. Schaafsma D, Gosens R, Bos IS, Meurs H, Zaagsma J, and Nelemans SA (2005) Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction. Respir Res 6:85.
36. Scichilone N and Togias A (2004) The role of lung inflation in airway hyperresponsiveness and in asthma. Curr Allergy Asthma Rep 4:166-174. (Pubitemid 38906758)
37. Stephens NL, Kroeger EA, and Kromer U (1975) Induction of a myogenic response in tonic airway smooth muscle by tetraethylammonium. Am J Physiol 228:628-632.
38. Swedin L, Ellis R, Neimert-Andersson T, Ryrfeldt A, Nilsson G, Inman M, Dahlén SE, and Adner M (2010) Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant. Prostaglandins Other Lipid Mediat 92:44-53.
39. Thulesius O and Mustafa S (1994) Stretch-induced myogenic responses of airways after histamine and carbachol. Clin Physiol 14:135-143. (Pubitemid 24101991)