Brain regional pharmacokinetics of p-aminosalicylic acid and its n-acetylated metabolite: Effectiveness in chelating brain manganese

Drug Metabolism and Disposition

Volumn 39, Issue 10, 2011, Pages 1904-1909

  Hong, Lan ^a,b   Jiang, Wendy ^a   Pan, Hao ^b   Jiang, Yueming ^c   Zeng, Su ^b   Zheng, Wei ^a  

^a PURDUE UNIVERSITY   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID; AMINOSALICYLIC ACID DERIVATIVE; MANGANESE; N ACETYL 4 AMINO 2 HYDROXYBENZOIC ACID; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

AMINOSALICYLIC ACID; AMINOSALICYLIC ACIDS; ANIMALS; ANTITUBERCULAR AGENTS; BRAIN; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INFUSIONS, INTRAVENOUS; MALE; MANGANESE; PARKINSONIAN DISORDERS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

PARKINSONIA; RATTUS;

EID: 80053140678     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.040915     Document Type: Article

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