Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 1, 2011, Pages 257-266

  Chi, Yuan ^a   Li, Kai ^a,b   Yan, Qiaojing ^a   Koizumi, Schuichi ^a   Shi, Liye ^b   Takahashi, Shuhei ^a   Zhu, Ying ^a   Matsue, Hiroyuki ^c   Takeda, Masayuki ^a   Kitamura, Masanori ^a   Yao, Jian ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL ESTER); 7 OXO 7H BENZIMIDAZO[2,1 A]BENZ[DE]ISOQUINOLINE 3 CARBOXYLIC ACID ACETATE; CALCIMYCIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE BETA; CALCIUM CHELATING AGENT; CALCIUM IONOPHORE; CYCLOSPORIN; FLUFENAMIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MECLOFENAMIC ACID; MEFENAMIC ACID; NIFLUMIC ACID; PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA; STO 609; THREONINE; TOLFENAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM DEPLETION; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR CALCIUM; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALKALINE PHOSPHATASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CALCIUM; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; EPITHELIAL CELLS; FLUFENAMIC ACID; HUMANS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; SWINE; TRANSFECTION;

EID: 80053136366     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.183020     Document Type: Article

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