Transcriptome dissection of gastric cancer: Identification of novel diagnostic and therapeutic targets from pathology specimens: Review Article

Pathology International

Volumn 59, Issue 3, 2009, Pages 121-136

  Yasui, Wataru ^a   Oue, Naohide ^a   Sentani, Kazuhiro ^a   Sakamoto, Naoya ^a   Motoshita, Junichi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Claudin 18; Gastric cancer; GW112; PLUNC; Reg IV; Serial analysis of gene expression; SOX9; SPC18; Transcriptome dissection

Indexed keywords

CANCER GROWTH FACTOR; CANCER GROWTH FACTOR ALPHA; CISPLATIN; CLAUDIN 18; FLUOROURACIL; ONCOPROTEIN; PEPTIDASE; PLUNC PROTEIN; PROTEIN CDH17; PROTEIN GW112; SIGNAL PEPTIDASE COMPLEX 18; STROMELYSIN 2; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR SOX9; TRANSCRIPTOME; UNCLASSIFIED DRUG;

CANCER DIAGNOSIS; CANCER GROWTH; CANCER STAGING; CARCINOGENESIS; CELL DIFFERENTIATION; GENE CONTROL; GENE EXPRESSION; GENE IDENTIFICATION; HISTOPATHOLOGY; HUMAN; NONHUMAN; PERITONEUM METASTASIS; PHENOTYPE; PRIORITY JOURNAL; REGENERATING ISLET DERIVED FAMILY MEMBER 4 GENE; REVIEW; SERIAL ANALYSIS OF GENE EXPRESSION; STOMACH CANCER; TUMOR GENE; UPREGULATION;

GENE EXPRESSION PROFILING; GENE LIBRARY; HUMANS; PATHOLOGY, CLINICAL; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 60649115305     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2009.02329.x     Document Type: Review

References (76)

1. Yasui W, Oue N, Kitadai Y, Nakayama H. Recent advances in molecular pathobiology of gastric carcinoma. In : Kaminishi M, Takubo K, Mafune K, eds. The Diversity of Gastric Carcinoma. Tokyo : Springer-Verlag, 2005 51 71.
2. Yasui W, Oue N, Ono S, Mitani Y, Ito R, Nakayama H. Histone acetylation and gastrointestinal carcinogenesis. Ann N Y Acad Sci 2003 983 : 220 31.
3. Ohgaki H, Matsukura N. Stomach cancer. In : Stewart BW, Kleihues P, eds. World Cancer Report. Lyon : IARC Press, 2003 194 7.
4. Tahara E. Development, growth and progression of human gastric cancer: Molecular pathological approach. Tr Soc Pathol Jpn 1992 81 : 21 49.
5. Tahara E. Molecular mechanism of stomach carcinogenesis. J Cancer Res Clin Oncol 1993 119 : 265 72.
6. Yasui W, Sentani K, Motoshita J, Nakayama H. Molecular pathobiology of gastric cancer. Scand J Surg 2006 95 : 225 31.
7. Yasui W, Yokozaki H, Shimamoto F, Tahara H, Tahara E. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology. Pathol Int 1999 49 : 763 74.
8. Yasui W, Oue N, Kuniyasu H, Ito R, Tahara E, Yokozaki H. Molecular diagnosis of gastric cancer: Present and future. Gastric Cancer 2001 4 : 113 21.
9. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular-pathological prognostic factors of gastric cancer: A review. Gastric Cancer 2005 8 : 86 94.
10. Velculescu VE, Zhang L, Vogelstein B, Kinzler KW. Serial analysis of gene expression. Science 1995 270 : 484 7.
11. El-Rifai W, Moskaluk CA, Abdrabbo MK et al. Gastric cancers overexpress S100A calcium-binding proteins. Cancer Res 2002 62 : 6823 6.
12. Oien KA, Vass JK, Downie I, Fullarton G, Keith WN. Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach. Oncogene 2003 22 : 4287 300.
13. Lee JY, Eom EM, Kim DS, Ha-Lee YM, Lee DH. Analysis of gene expression profiles of gastric normal and cancer tissues by SAGE. Genomics 2003 82 : 78 85.
14. Oue N, Hamai Y, Mitani Y et al. Gene expression profile of gastric carcinoma: Identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res 2004 64 : 2397 405.
15. Yasui W, Oue N, Ito R, Kuraoka K, Nakayama H. Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications. Cancer Sci 2004 95 : 385 92.
16. Ossandon FJ, Villarroel C, Aguayo F et al. In silico analysis of gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity. Mol Cancer 2008 7 : 22.
17. Aung PP, Oue N, Mitani Y et al. Systematic search for gastric cancer-specific genes based on SAGE data: Melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. Oncogene 2006 25 : 2546 57.
18. Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK. Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim Biophys Acta 2001 1518 : 287 93.
19. Violette S, Festor E, Pandrea-Vasile I et al. Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int J Cancer 2003 103 : 185 93.
20. Zhang Y, Lai M, Lv B et al. Overexpression of Reg IV in colorectal adenoma. Cancer Lett 2003 200 : 69 76.
21. Oue N, Mitani Y, Aung PP et al. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol 2005 207 : 185 98.
22. Mitani Y, Oue N, Matsumura S et al. Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene 2007 26 : 4383 93.
23. Kuniyasu H, Oue N, Sasahira T et al. Reg IV enhances peritoneal metastasis of gastric carcinomas. Cell Prolif 2009 (in press).
24. Miyagawa K, Sakakura C, Nakashima S et al. Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis. Anticancer Res 2008 28 : 1169 79.
25. Yasui W, Sentani K, Sakamoto N, Motoshita J, Oue N. Histological and serological tumor markers of gastric cancer. In : Hellberg D, ed. Histological and Serological Tumor Markers and Their Clinical Usefulness in Cancer. New York : Nova Publishers, 2009 in press).
26. Zhang J, Liu WL, Tang DC et al. Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Gene 2002 283 : 83 93.
27. Koshida S, Kobayashi D, Moriai R, Tsuji N, Watanabe N. Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci 2007 98 : 315 20.
28. Liu W, Liu Y, Zhu J, Wright E, Ding I, Rodgers GP. Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma. Clin Cancer Res 2008 14 : 1041 9.
29. Zhang X, Huang Q, Yang Z, Li Y, Li CY. GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res 2004 64 : 2474 81.
30. Liu W, Chen L, Zhu J, Rodgers GP. The glycoprotein hGC-1 binds to cadherin and lectins. Exp Cell Res 2006 312 : 1785 97.
31. Oue N, Aung PP, Mitani Y, Kuniyasu H, Nakayama H, Yasui W. Genes involved in invasion and metastasis of gastric cancer identified by array-based hybridization and serial analysis of gene expression. Oncology 2005 69 (Suppl. 1 17 22.
32. Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: Biologic activity and clinical implications. J Clin Oncol 2000 18 : 1135 49.
33. Paetzel M, Karla A, Strynadka NC, Dalbey RE. Signal peptidases. Chem Rev 2002 102 : 4549 80.
34. Evans EA, Gilmore R, Blobel G. Purification of microsomal signal peptidase as a complex. Proc Natl Acad Sci USA 1986 83 : 581 5.
35. Liang H, VanValkenburgh C, Chen X et al. Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex. J Biol Chem 2003 278 : 50 932 9.
36. Sentani K, Oue N, Tashiro T et al. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. Am J Surg Pathol 2008 32 : 1182 9.
37. Sentani K, Oue N, Sakamoto N et al. Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. Mod Pathol 2008 21 : 464 75.
38. Weston WM, LeClair EE, Trzyna W et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem 1999 274 : 13 698 703.
39. Bingle CD, Bingle L. Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. Biochim Biophys Acta 2000 1493 : 363 7.
40. Bingle L, Cross SS, High AS et al. SPLUNC1 (PLUNC) is expressed in glandular tissues of the respiratory tract and in lung tumours with a glandular phenotype. J Pathol 2005 205 : 491 7.
41. Iwao K, Watanabe T, Fujiwara Y et al. Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Int J Cancer 2001 91 : 433 7.
42. Ishikura H, Kirimoto K, Shamoto M et al. Hepatoid adenocarcinomas of the stomach. An analysis of seven cases. Cancer 1986 58 : 119 26.
43. Chang YC, Nagasue N, Abe S, Taniura H, Kumar DD, Nakamura T. Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers. Am J Gastroenterol 1992 87 : 321 5.
44. Terracciano LM, Glatz K, Mhawech P et al. Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: An immunohistochemical and molecular study of eight cases. Am J Surg Pathol 2003 27 : 1302 12.
45. Nakamura K, Sugano H, Takagi K. Carcinoma of the stomach in incipient phase: Its histogenesis and histological appearance. Gann 1968 59 : 251 8.
46. Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at histo-clinical classification. Acta Pathol Microbiol Scand 1965 64 : 31 49.
47. Tatematsu M, Tsukamoto T, Inada K. Stem cells and gastric cancer: Role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 2003 94 : 135 41.
48. Tatematsu M, Tsukamoto T, Mizoshita T. History of gastric carcinoma research in Japan: Basic aspects. In : Kaminishi M, Takubo K, Mafune K, eds. The Diversity of Gastric Carcinoma: Pathogenesis, Diagnosis and Therapy. Tokyo : Springer, 2005 3 28.
49. Almeida R, Silva E, Santos-Silva F et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 2003 199 : 36 40.
50. Tsukamoto T, Mizoshita T, Mihara M et al. Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes. Histopathology 2005 46 : 649 58.
51. Kushima R, Muller W, Stolte M, Borchad F. Differential p53 protein expression in stomach adenomas of gastric and intestinal phenotypes: Possible sequences of p53 alteration in stomach carcinogenesis. Virchows Arch 1996 428 : 223 7.
52. Shibata N, Watari J, Fujiya M, Tanno S, Saitoh Y, Kohgo Y. Cell kinetics and genetic instabilities in differentiated type early gastric cancers with different mucin phenotype. Hum Pathol 2003 34 : 32 40.
53. Tajima Y, Shimoda T, Nakanishi Y et al. Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: Immunohistochemical analysis of 136 lesions. Oncology 2001 61 : 212 20.
54. Hinoi T, Lucas PC, Kuick R, Hanash S, Cho KR, Fearon ER. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 2002 123 : 1565 77.
55. Schepers GE, Teasdale RD, Koopman P. Twenty pairs of sox: Extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 2002 3 : 167 70.
56. Blache P, van de Wetering M, Duluc I et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol 2004 166 : 37 47.
57. Bastide P, Darido C, Pannequin J et al. Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol 2007 178 : 635 48.
58. Lawrence HJ, Largman C. Homeobox genes in normal hematopoiesis and leukemia. Blood 1992 80 : 2445 53.
59. Bromleigh VC, Freedman LP. p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells. Genes Dev 2000 14 : 2581 6.
60. Slany RK. When epigenetics kills: MLL fusion proteins in leukemia. Hematol Oncol 2005 23 : 1 9.
61. Sarno JL, Kliman HJ, Taylor HS. HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: Formation of multimeric complexes on HOXA10 target genes. J Clin Endocrinol Metab 2005 90 : 522 8.
62. Yoshida H, Broaddus R, Cheng W, Xie S, Naora H. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: Role in epithelial-mesenchymal transition. Cancer Res 2006 66 : 889 97.
63. Rawat VP, Thoene S, Naidu VM et al. Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia. Blood 2008 111 : 309 19.
64. Sanada Y, Oue N, Mitani Y, Yoshida K, Nakayama H, Yasui W. Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype. J Pathol 2006 208 : 633 42.
65. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001 2 : 285 93.
66. Swisshelm K, Macek R, Kubbies M. Role of claudins in tumorigenesis. Adv Drug Deliv Rev 2005 57 : 919 28.
67. Niimi T, Nagashima K, Ward JM et al. Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol 2001 21 : 7380 90.
68. Yano K, Imaeda T, Niimi T. Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells. Am J Physiol Gastrointest Liver Physiol 2008 294 : G336 43.
69. Gonzalez CA, Sala N, Capella G. Genetic susceptibility and gastric cancer risk. Int J Cancer 2002 100 : 249 60.
70. Watters JW, McLeod HL. Cancer pharmacogenomics: Current and future applications. Biochim Biophys Acta 2003 1603 : 99 111.
71. Ito R, Oue N, Yoshida K et al. Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch 2005 447 : 717 22.
72. Berndorff D, Gessner R, Kreft B et al. Liver-intestine cadherin: Molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine. J Cell Biol 1994 125 : 1353 69.
73. Dantzig AH, Hoskins JA, Tabas LB et al. Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science 1994 264 : 430 33.
74. Ko S, Chu KM, Luk JM et al. Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. Biochem Biophys Res Commun 2004 319 : 562 8.
75. Ko S, Chu KM, Luk JM et al. CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. J Pathol 2005 205 : 615 22.
76. Ferguson DA, Muenster MR, Zang Q et al. Selective identification of secreted and transmembrane breast cancer markers using Escherichia coli ampicillin secretion trap. Cancer Res 2005 65 : 8209 17.