Cytomegalovirus disease, haemophagocytic syndrome, immunosuppression in patients with IBD: 'A cocktail best avoided, not stirred'

Journal of Crohn's and Colitis

Volumn 5, Issue 5, 2011, Pages 469-472

  Van Langenberg, Daniel R ^a   Morrison, Graham ^a   Foley, Anna ^a   Buttigieg, Raymond J ^a   Gibson, Peter R ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Antiviral therapy; Cytomegalovirus; Immunosuppression; Inflammatory bowel disease

Indexed keywords

AZATHIOPRINE; AZITHROMYCIN; CIPROFLOXACIN; COTRIMOXAZOLE; ENEMA; FOSCARNET; GANCICLOVIR; HYDROCORTISONE; IMMUNOMODULATING AGENT; INOTROPIC AGENT; MEROPENEM; MESALAZINE; OSELTAMIVIR; PENICILLIN DERIVATIVE; PENTAMIDINE; TAZOBACTAM; VANCOMYCIN; VORICONAZOLE;

ABNORMAL RESPIRATORY SOUND; ADULT; ANTIVIRAL THERAPY; ARTICLE; ARTIFICIAL VENTILATION; AVERSIVE BEHAVIOR; BONE MARROW BIOPSY; BRONCHOSCOPY; CASE REPORT; COLON CROHN DISEASE; COLONOSCOPY; COLOSTOMY; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; CROHN DISEASE; CYTOMEGALOVIRUS INFECTION; DISEASE COURSE; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG WITHDRAWAL; DYSPNEA; ENTERITIS; FEMALE; FUNGEMIA; HEMATOLOGICAL PARAMETERS; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HUMAN; IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; LIVER FUNCTION TEST; LUNG AUSCULTATION; MAINTENANCE THERAPY; PANCYTOPENIA; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTOSIS; PNEUMONIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REMISSION; RESPIRATORY DISTRESS; RESPIRATORY FAILURE; RESPIRATORY TRACT INTUBATION; SORE THROAT; TACHYCARDIA; THORAX RADIOGRAPHY; TRACHEOBRONCHIAL TOILET; ULCERATIVE COLITIS; VIRUS REACTIVATION;

ADULT; AZATHIOPRINE; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; PNEUMONIA; VIREMIA;

EID: 80053133554     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2011.04.010     Document Type: Article

References (28)

1. Rahier J.F., Ben-Horin S., Chowers Y., Conlon C., De Munter P., D'Haens G., Domenech E., Eliakim R., Eser A., Frater J., Gassull M., Giladi M., Kaser A., Lemann M., Moreels T., Moschen A., Pollok R., Reinisch W., Schunter M., Stange E.F., Tilg H., Van Assche G., Viget N., Vucelic B., Walsh A., Weiss G., Yazdanpanah Y., Zabana Y., Travis S.P., Colombel J.F. European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis 2009, 3:47-91.
2. Filik L. Cytomegalovirus infection and inflammatory bowel disease. Dig Dis Sci 2010, 55:869.
3. de Saussure P., Lavergne-Slove A., Mazeron M.C., Alain S., Matuchansky C., Bouhnik Y. A prospective assessment of cytomegalovirus infection in active inflammatory bowel disease. Aliment Pharmacol Ther 2004, 20:1323-1327.
4. Hookey L.C., Depew W., Boag A., Vanner S. 6-mercaptopurine and inflammatory bowel disease: hidden ground for the cytomegalovirus. Can J Gastroenterol 2003, 17:319-322.
5. Papadakis K.A., Tung J.K., Binder S.W., Kam L.Y., Abreu M.T., Targan S.R., Vasiliauskas E.A. Outcome of cytomegalovirus infections in patients with inflammatory bowel disease. Am J Gastroenterol 2001, 96:2137-2142.
6. Dimitroulia E., Spanakis N., Konstantinidou A.E., Legakis N.J., Tsakris A. Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease. Inflamm Bowel Dis 2006, 12:879-884.
7. Pickering O., Weinstein T., Rubin L.G. Fatal disseminated cytomegalovirus infection associated with infliximab and 6-mercaptopurine therapy in a child with Crohn disease. Pediatr Infect Dis J 2009, 28:556.
8. Babu T.G., Boctor D., Davey A., Bond M.C., Jacobson K. Cytomegalovirus-associated hemophagocytic syndrome in a child with Crohn disease receiving azathioprine. J Pediatr Gastroenterol Nutr 2004, 39:418-421.
9. Caprilli R., Latella G., Vernia P., Frieri G. Multiple organ dysfunction in ulcerative colitis. Am J Gastroenterol 2000, 95:1258-1262.
10. Larroche C., Mouthon L. Pathogenesis of hemophagocytic syndrome (HPS). Autoimmun Rev 2004, 3:69-75.
11. James D.G., Stone C.D., Wang H.L., Stenson W.F. Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease. Inflamm Bowel Dis 2006, 12:573-580.
12. Imashuku S. Hyperferritinemia in hemophagocytic lymphohistiocytosis and related diseases. Pediatr Blood Cancer 2008, 51:442.
13. Karras A., Thervet E., Legendre C. Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature. Transplantation 2004, 77:238-243.
14. Monteleone G., Caprioli F. T-cell-directed therapies in inflammatory bowel diseases. Clin Sci (Lond) 2010, 118:707-715.
15. La Rosa C., Limaye A.P., Krishnan A., Longmate J., Diamond D.J. Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease. J Infect Dis 2007, 195:633-644.
16. Domenech E., Vega R., Ojanguren I., Hernandez A., Garcia-Planella E., Bernal I., Rosinach M., Boix J., Cabre E., Gassull M.A. Cytomegalovirus infection in ulcerative colitis: a prospective, comparative study on prevalence and diagnostic strategy. Inflamm Bowel Dis 2008, 14:1373-1379.
17. Matsuoka K., Iwao Y., Mori T., Sakuraba A., Yajima T., Hisamatsu T., Okamoto S., Morohoshi Y., Izumiya M., Ichikawa H., Sato T., Inoue N., Ogata H., Hibi T. Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients. Am J Gastroenterol 2007, 102:331-337.
18. Leveque N., Brixi-Benmansour H., Reig T., Renois F., Talmud D., Brodard V., Coste J.F., De Champs C., Andreoletti L., Diebold M.D. Low frequency of cytomegalovirus infection during exacerbations of inflammatory bowel diseases. J Med Virol 2010, 82:1694-1700.
19. Menasche G., Feldmann J., Fischer A., de Saint Basile G. Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis. Immunol Rev 2005, 203:165-179.
20. Lee S.O., Razonable R.R. Current concepts on cytomegalovirus infection after liver transplantation. World J Hepatol 2010, 2:325-336.
21. Rubin D.T., Parekh N. Colorectal cancer in inflammatory bowel disease: molecular and clinical considerations. Curr Treat Options Gastroenterol 2006, 9:211-220.
22. Ochsenkuhn T., Tillack C., Stepp H., Diebold J., Ott S.J., Baumgartner R., Brand S., Goke B., Sackmann M. Low frequency of colorectal dysplasia in patients with long-standing inflammatory bowel disease colitis: detection by fluorescence endoscopy. Endoscopy 2006, 38:477-482.
23. Raithel M., Winterkamp S., Pacurar A., Ulrich P., Hochberger J., Hahn E.G. Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease. Scand J Gastroenterol 2001, 36:174-179.
24. Ponticelli C. The pleiotropic effects of mTor inhibitors. J Nephrol 2004, 17:762-768.
25. Lynch H.T., Brand R.E., Locker G.Y. Inflammatory bowel disease in Ashkenazi Jews: implications for familial colorectal cancer. Fam Cancer 2004, 3:229-232.
26. Cvetkovic R.S., Wellington K. Valganciclovir: a review of its use in the management of CMV infection and disease in immunocompromised patients. Drugs 2005, 65:859-878.
27. Sun H.Y., Wagener M.M., Singh N. Prevention of posttransplant cytomegalovirus disease and related outcomes with valganciclovir: a systematic review. Am J Transplant 2008, 8:2111-2118.
28. Ghaffari S.H., Obeidi N., Dehghan M., Alimoghaddam K., Gharehbaghian A., Ghavamzadeh A. Monitoring of cytomegalovirus reactivation in bone marrow transplant recipients by real-time PCR. Pathol Oncol Res 2008, 14:399-409.