Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 37, 2011, Pages 15486-15491

  Shinohara, Tadashi ^a   Michikawa, Takayuki ^a,b   Enomoto, Masahiro ^a,d,e   Goto, Jun Ichi ^a,f   Iwai, Miwako ^c   Matsu ura, Toru ^a,g   Yamazaki, Haruka ^a   Miyamoto, Akitoshi ^a,c   Suzuki, Akio ^a   Mikoshiba, Katsuhiko ^a,b  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d PRINCESS MARGARET HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f YAMAGATA UNIVERSITY   (Japan)

^g UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium signal; Channel gating; Ion channel

Indexed keywords

CALCIUM; CALCIUM ION; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; LIGAND; NEURONAL CALCIUM SENSOR; RYANODINE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMALS; BACTERIAL PROTEINS; CALCIUM; CYTOSOL; FLUORESCENCE RESONANCE ENERGY TRANSFER; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; ION CHANNEL GATING; LIGANDS; LUMINESCENT PROTEINS; MICE; MODELS, BIOLOGICAL; RECOMBINANT FUSION PROTEINS;

EID: 80053080491     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101677108     Document Type: Article

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