Spontaneous Channel Activity of the Inositol 1,4,5-Trisphosphate (InsP 3) Receptor (InsP3R). Application of Allosteric Modeling to Calcium and InsP3 Regulation of InsP3R Single-channel Gating

Journal of General Physiology

Volumn 122, Issue 5, 2003, Pages 583-603

  Mak, Don On Daniel ^a   McBride, Sean M J ^a   Foskett, J Kevin ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Calcium; Nucleus; Patch clamp; Single channel electrophysiology; Xenopus oocyte

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE; ISOPROTEIN; LIGAND; RECOMBINANT PROTEIN; TETRAMER;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL NUCLEUS; CHANNEL GATING; ELECTROPHYSIOLOGY; FEMALE; LIGAND BINDING; MEMBRANE CHANNEL; MODEL; NONHUMAN; OOCYTE; PATCH CLAMP; PREDICTION; PROTEIN CONFORMATION; REGULATORY MECHANISM; SINGLE CHANNEL GATING; STEADY STATE; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ION CHANNEL GATING; MEMBRANE POTENTIALS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; XENOPUS LAEVIS;

EID: 0242460529     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200308809     Document Type: Article

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