Catalytic route to a concise stereoselective synthesis of cytotoxic (3S,5S)-1-(4-hydroxyphenyl)-7-phenylheptane-3,5-diol and its (3R,5S)-isomer

Synthesis

Volumn , Issue 19, 2011, Pages 3180-3184

  Purushothamreddy, S ^a   Ashalatha, K ^a   Kumarreddy, D ^a   Chinnababu, B ^a   Venkateswarlu, Y ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

cytotoxic; diarylheptanoids; Jacobsens hydrolytic kinetic resolution; Maruoka asymmetric allylation

Indexed keywords

ASYMMETRIC ALLYLATION; CYTOTOXIC; DIARYLHEPTANOIDS; HYDROLYTIC KINETIC RESOLUTION; STEREOSELECTIVE SYNTHESIS;

ALLYLATION; STEREOCHEMISTRY; STEREOSELECTIVITY; TITANIUM; TITANIUM OXIDES;

ISOMERS;

1 (4 HYDROXY 3 METHOXYPHENYL) 7 PHENYLHEPTANE 3,5 DIOL; 1 (4 HYDROXYPHENYL) 7 PHENYLHEPTANE 3,5 DIOL; 1 [4 (BENZYLOXY)PHENYL] 5 (TERT BUTYLDIPHENYLSILOXY) 7 PHENYLHEPTAN 3 OL; 1 PHENYLHEX 5 EN 3 OL; 1,7 DIPHENYLHEPTANE 3,5 DIOL; 2 [2 (TERT BUTYLDIPHENYLSILOXY) 4 PHENYLBUTYL]OXIRANE; 4 (TERT BUTYLDIPHENYLSILOXY) 6 PHENYL 1 (TOSYLOXY)HEXAN 2 OL; 4 (TERT BUTYLDIPHENYLSILOXY) 6 PHENYLHEX 1 ENE; 4 (TERT BUTYLDIPHENYLSILOXY) 6 PHENYLHEXANE 1,2 DIOL; CYTOTOXIC AGENT; DIOL 7; EPOXIDE; ETHYLENE OXIDE; UNCLASSIFIED DRUG;

ALLYLATION; ARTICLE; CATALYSIS; CHEMICAL INTERACTION; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS KINETICS; STEREOCHEMISTRY;

EID: 80053053191     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260183     Document Type: Article

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