Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer

European Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2010, Pages 4657-4663

  Reddy, D Kumar ^a   Shekhar, V ^a   Prabhakar, P ^a   Chinna Babu, B ^a   Siddhardha, B ^a   Murthy, U S N ^a   Venkateswarlu, Y ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

(6R) (4R) hydroxy 6 phenyl hex 2 enyl) 5,6 dihydro pyran 2 one; (R) rugulactone; Antibacterial activity; Antifungal activity; Inhibitor of NF B activation pathway

Indexed keywords

(4 OXO 6 PHENYL HEX 2 ENYL) 5,6 DIHYDRO PYRAN 2 ONE; (HYDROXY 6 PHENYL HEX 2 ENYL) 5,6 DIHYDRO PYRAN 2 ONE; PROLINE; PYRONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CATALYSIS; CHIRALITY; CONTROLLED STUDY; DRUG SYNTHESIS; EPIMER; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MITSUNOBU REACTION; NONHUMAN; PSEUDOMONAS AERUGINOSA; SHARPLESS EPOXIDATION; STEREOCHEMISTRY;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CRYPTOCARYA; FUNGI; HUMANS; LACTONES; MICROBIAL SENSITIVITY TESTS; MYCOSES; NF-KAPPA B; PYRONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956186938     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.036     Document Type: Article

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