Increased breast density correlates with the proliferation-seeking radiotracer 99mTc(V)-DMSA uptake in florid epithelial hyperplasia and in mixed ductal carcinoma in situ with invasive ductal carcinoma but not in pure invasive ductal carcinoma or in mild epithelial hyperplasia

Molecular Imaging

Volumn 10, Issue 5, 2011, Pages 370-376

  Papantoniou, Vassilios ^a   Valsamaki, Pipitsa ^b   Sotiropoulou, Evangelia ^c   Tsaroucha, Angeliki ^a   Tsiouris, Spyridon ^a   Sotiropoulou, Maria ^a   Marinopoulos, Spyridon ^a   Kounadi, Evangelia ^a   Karianos, Theodore ^a   Fothiadaki, Athina ^a   Archontaki, Aikaterini ^a   Syrgiannis, Konstantinos ^a   Ptohis, Nikolaos ^a   Makris, Nikolaos ^a   Limouris, Georgios ^a   Antsaklis, Aris ^a  

^a Departments of Nuclear Medicine   (Greece)

^b SOTIRIA GENERAL HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION KINASE; BREAST DENSITY; BREAST PATHOLOGY; CANCEROUS LESIONS; COMPUTER-ASSISTED METHODS; DIMERCAPTOSUCCINIC ACIDS; DUCTAL CARCINOMA; DUCTAL CARCINOMA IN SITU; MAMMOGRAPHIC; MICROENVIRONMENTS; SCINTIMAMMOGRAPHY; TECHNETIUM-99M;

ADHESION; CHEMICAL ACTIVATION; DISEASES; HISTOLOGY; MAMMOGRAPHY; PATHOLOGY; REGRESSION ANALYSIS; TECHNETIUM;

RADIOACTIVE TRACERS;

DIAGNOSTIC AGENT; SUCCIMER TC 99M;

ADULT; AGED; ARTICLE; BREAST; BREAST TUMOR; COHORT ANALYSIS; FEMALE; HUMAN; HYPERPLASIA; MAMMOGRAPHY; METABOLISM; METHODOLOGY; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY; SCINTISCANNING; STATISTICAL MODEL;

ADULT; AGED; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; COHORT STUDIES; FEMALE; HUMANS; HYPERPLASIA; LINEAR MODELS; MAMMOGRAPHY; MIDDLE AGED; TECHNETIUM TC 99M DIMERCAPTOSUCCINIC ACID;

EID: 80053036554     PISSN: 15353508     EISSN: None     Source Type: Journal    
DOI: 10.2310/7290.2010.00056     Document Type: Article

References (44)

1. Ursin G, Hovanessian-Larsen L, Parisky YR, et al. Greatly increased occurrence of breast cancers in areas of mammographically dense tissue. Breast Cancer Res 2005;7:R605-8, doi:10.1186/bcr1260.
2. Mitchell J, Antoniou AC, Warren R, et al. Mammographic density and breast cancer risk in BRCA 1 and BRCA2 mutations carriers. Cancer Res 2006;66:1866-72, doi:10.1158/0008-5472.CAN-05- 3368. (Pubitemid 43259974)
3. Boyd NF, Guo H, Martin LJ, et al. Mammographic density and the risk and detection of breast cancer. N Engl J Med 2007;356:227-36, doi:10.1056/ NEJMoa062790. (Pubitemid 46143226)
4. Gill JK, Maskarinec G, Pagano I, Kolonel LN. The association of mammographic density with ductal carcinoma in situ of the breast: the Multiethnic Cohort. Breast Cancer Res 2006;8:R30, doi:10.1186/bcr1507. (Pubitemid 43951066)
5. Friedenreich CM, Bryant HE, Alexander F, et al. Risk factors for benign proliferative breast disease. Int J Epidemiol 2000;29:637-44, doi:10.1093/ije/29.4.637. (Pubitemid 30612229)
6. Ashbeck EL, Rosenberg RD, Stauber P, Key CR. Benign breast biopsy diagnosis and subsequent risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2007;16:467-72, doi:10.1158/1055- 9965.EPI-06-0394. (Pubitemid 46548650)
7. Bright RA, Morrison AS, Brisson J, et al. Relationship between mammographic and histologic features of breast tissue in women with benign biopsies. Cancer 1988;61:266-71, doi:10.1002/1097- 0142(19880115)61:2,266::AID- CNCR2820610212.3.0.CO;2-N. (Pubitemid 18056481)
8. Urbanski S, Jensen HM, McFarlane D, et al. The association of histologic and radiologic indicators of breast cancer risk. Br J Cancer 1988;58:474-9. (Pubitemid 18267803)
9. Carvalho I, Milanezi F, Martins A, et al. Overexpression of platelet derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res 2005;7:R788-95, doi:10.1186/bcr1304.
10. Guidi AJ, Schnitt SJ, Fischer L, et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer 1997; 80:1945-53, doi:10.1002/(SICI)1097-0142(19971115)80:10,1945:: AID-CNCR11.3.0.CO;2-Y. (Pubitemid 27479789)
11. Heffelfinger SC, Miller MA, Yassin R, Gear R. Angiogenic growth factors in preinvasive breast disease. Clin Cancer Res 1999;5:2867-76. (Pubitemid 29493965)
12. Anan K, Morisaki T, Katano M, et al. Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. Surgery 1996;119: 333-9, doi:10.1016/S0039- 6060(96)80120-6. (Pubitemid 26082669)
13. Bhardwaj B, Klassen J, Cossette N, et al. Localization of plateletderived growth factor beta receptor expression in the periepithelial stroma of human breast carcinoma. Clin Cancer Res 1996;2:773-82. (Pubitemid 26135343)
14. Toda M, Suzuki T, Hosono K, et al. Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci U S A 2008;105:13550-5, doi:10.1073/pnas.0800767105.
15. 99mTc(V)-DMSA scintimammography. Am J Clin Oncol 2007;30:420-7, doi:10.1097/ COC.0b013e3180337792. (Pubitemid 47356687)
16. 99mTc(V)-DMSA in detecting tumor cell proliferation. Anal Chem Insights 2007;2:81-3.
17. Ohta H, Yamamoto K, Endo K, et al. A new imaging agent for medullary carcinoma of the thyroid. J Nucl Med 1984;25:323-5. (Pubitemid 14152918)
18. 99mTc-sestamibi in the assessment of histological type and grade in breast cancer. Nucl Med Commun 2002;23:461-7, doi:10.1097/00006231- 200205000-00006. (Pubitemid 34478467)
19. Hirano T, Otake H, Kazama K, et al. Technetium-99m(V)-DMSA and thallium-201 in brain tumor imaging: correlation with histology and malignant grade. J Nucl Med 1997;38:1741-9. (Pubitemid 27495522)
20. Hirano T, Otake H, Yoshida I, Endo K. Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA. J Nucl Med 1995;36:202-7.
21. Atasever T, Gundogdu C, Vural G, et al. Evaluation of pentavalent Tc-99m DMSA scintigraphy in small cell and nonsmall cell lung cancers. Nuklearmedizin 1997;36:223-7. (Pubitemid 27489457)
22. 99mTc-DMSA imaging in patients with bone metastases. Nucl Med Commun 1997;18:907-14, doi:10.1097/00006231-199710000-00003. (Pubitemid 27497503)
23. 99mTc-labelled pentavalent DMSA and its evaluation as a tumour imaging agent. J Nucl Biol Med 1991;35:100-4.
24. Kashyap R, Babbar A, Sahai I, et al. Tc-99 m(V) DMSA imaging. A new approach to studying metastases from breast carcinoma. Clin Nucl Med 1992;17:119-22, doi:10.1097/00003072-199202000-00011.
25. Kiratli H, Kiratli PO, Ercan MT. Scintigraphic evaluation of tumors metastatic to the choroid using technetium-99m(V)- dimercaptosuccinic acid. Jpn J Ophthalmol 1998;42:60-5, doi:10.1016/S0021-5155(97)00110-X. (Pubitemid 28097436)
26. 99mTc- (V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines. Eur J Nucl Med Mol Imaging 2005;32:820-7, doi:10.1007/s00259-005-1773-4. (Pubitemid 41125425)
27. 99mTc-(V) - DMSA uptake is mediated by NaPi cotransporter type III in tumour cell lines. Eur J Nucl Med Mol Imaging 2004;31:77-84, doi:10.1007/s00259-003-1334-7. (Pubitemid 38133544)
28. 99mTc(V)-DMSA uptake in breast cancer. Breast Cancer Res 2004;6:R56-62, doi:10.1186/bcr751.
29. Papantoniou V, Tsiouris S, Koutsikos J, et al. Scintimammographic detection of usual ductal breast hyperplasia with increased proliferation rate at risk for malignancy. Nucl Med Commun 2006;27:911-7, doi:10.1097/01.mnm. 0000243367.73141.85. (Pubitemid 44526730)
30. Papantoniou V, Tsiouris S, Mainta E, et al. Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium- 99m 2-methoxy isobutyl isonitrile scintimammography. Breast Cancer Res 2005;7:R33-45, doi:10.1186/bcr948.
31. Papantoniou V, Ptohis N, Tsiouris S. Diffuse tracer uptake in scintimammography: not as nonspecific or benign as originally believed? J Nucl Med 2006;47:554-5. (Pubitemid 46768501)
32. Boyd NF, Lockgood GA, Byng JW, et al. Mammographic densities and breast cancer risks. Cancer Epidemiol Biomarkers Prev 1998;7: 1133-44. (Pubitemid 29001671)
33. Tamimi RM, Byrne C, Colditz GA, Hankinson SE. Endogenous hormone levels, mammographic density and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2007; 99:1178-87, doi:10.1093/jnci/djm062. (Pubitemid 47233068)
34. Chen C, Doherty JA, Lewis SK, et al. Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women. Int J Cancer 2006;118:2303-9, doi:10.1002/ijc.21624.
35. Tamimi RM, Cox DG, Kraft P, et al. Common genetic variation in IGF1, IGFBP-1 and IGFBP-3 in relation to mammographic density: a cross-sectional study. Breast Cancer Res 2007;9:R18, doi:10.1186/bcr1655. (Pubitemid 350215143)
36. Papantoniou V, Sotiropoulou E, Valsamaki P, et al. Breast density, scintimammographic (99m)Tc(V)DMSA uptake, and calcitonin gene related peptide (CGRP) expression in mixed invasive ductal associated with extensive in situ ductal carcinoma (IDC + DCIS) and pure invasive ductal carcinoma (IDC): correlation with estrogen receptor (ER) status, proliferation index Ki-67, and histological grade. Breast Cancer. 2010 Feb 9. [Epub ahead of print], doi:10.1007/s12282-009-0192-y.
37. George D. Platelet-derived growth factor receptors: a therapeutic target in solid tumors. Semin Oncol 2001;28 (5 Suppl 17):27-33, doi:10.1016/S0093- 7754(01)90100-9. (Pubitemid 33140515)
38. 99mTc-(V)-DMSA. Eur J Cancer 2006;42:1004-13, doi:10.1016/j.ejca. 2006.01.023. (Pubitemid 44275329)
39. Lightfoot HM, Lark A, Livasy CA, et al. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. Breast Cancer Res Treat 2004;88:109-16, doi:10.1007/s10549-004-1022-8. (Pubitemid 39575569)
40. Oktay MH, Oktay K, Hamele-Bena D, et al. Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol 2003;34:240-5, doi:10.1053/hupa. 2003.40. (Pubitemid 36356676)
41. Dittmann H, Jusufoska A, Dohmen BM, et al. 39-Deoxy-39- [(18)F]fluorothymidine (FLT) uptake in breast cancer cells as a measure of proliferation after doxorubicin and docetaxel treatment. Nucl Med Biol 2009;36:163-9, doi:10.1016/j.nucmedbio. 2008.10.012.
42. Bading JR, Shields AF. Imaging of cell proliferation: status and prospects. J Nucl Med 2008;49 Suppl 2:64S-80S, doi:10.2967/ jnumed.107.046391. (Pubitemid 351948037)
43. 18Fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. J Clin Oncol 2002;20: 379-87, doi:10.1200/JCO.20. 2.379. (Pubitemid 34072519)
44. 18F-FDG PET: histologic and immunohistochemical tissue analysis. J Nucl Med 2001;42:9-16. (Pubitemid 32104770)