Role of regulatory T cell populations in controlling graft vs host disease

Best Practice and Research: Clinical Haematology

Volumn 24, Issue 3, 2011, Pages 453-457

  Negrin, Robert S ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

graft vs host disease; NK T cells; regulatory T cells

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR FOXP3;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIVISION; CELL INFILTRATION; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CELL SELECTION; CELL SEPARATION; GRAFT VERSUS HOST REACTION; IMMUNIZATION; IMMUNOSUPPRESSIVE TREATMENT; MINOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE REACTION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PURIFICATION; REGULATORY T LYMPHOCYTE;

EID: 80053036234     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2011.05.006     Document Type: Review

References (16)

1. + regulatory T cells suppress lethal acute graft-versus-hosti disease after allogeneic bone marrow transplantation J Exp Med 196 2002 389
2. J.L. Cohen, A. Trenado, and D. Vasey CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease J Exp Med 196 2002 401
3. P.A. Taylor, C.J. Lees, and B.R. Blazar The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality Blood 99 2002 3493
4. S.C. Jones, G.F. Murphy, and R. Korngold Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response Biol Blood Marrow Transplant 9 2003 243
5. M. Edinger, P. Hoffmann, and J. Ermann CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation Nat Med 9 2003 1144
6. + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia J Clin Invest 112 2003 1688
7. R.S. Negrin, and C.H. Contag In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease Nat Rev Immunol 6 2006 484
8. V.H. Nguyen, R. Zeiser, and D.L. Dasilva In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation Blood 109 2007 2649
9. V.H. Nguyen, S. Shashidhar, and D.S. Chang The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation Blood 111 2008 945
10. D. Zeng, D. Lewis, and S. Dejbakhsh-Jones Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease J Exp Med 189 1999 1073
11. R. Lowsky, T. Takahashi, and Y.P. Liu Protective conditioning for acute graft-versus-host disease N Engl J Med 353 2005 1321
12. D.B. Leveson-Gower, J.A. Olson, E.I. Sega, R.H. Luong, J. Baker, R. Zeiser, and R.S. Negrin Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4 dependent mechanism Blood 117 2011 3220 3229
13. F. Aversa, A. Tabilio, and A. Velardi Transplantation for high-risk acute leukemia with high doses of T-cell-depeleted hematopoietic stem cells from full-haplotype incompatible donors N Engl J Med 339 1998 1186
14. Y. Reisner, and M.F. Martelli Transplantation tolerance induced by "mega dose" CD34+ cell transplants Exp Hematol 28 2000 119
15. M. Di Ianni, F. Falzetti, A. Carotti, A. Terenzi, F. Castellino, E. Bonifacio, B. Del Papa, T. Zei, R. Iacucci Ostini, D. Cecchini, T. Aloisi, K. Perruccio, L. Ruggeri, C. Balucani, A. Pierini, P. Sportoletti, C. Aristei, B. Falini, Y. Reisner, A. Velardi, F. Aversa, and M.F. Martelli Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation Blood 117 2011 3921 3928
16. + T reg cells J Exp Med 203 2006 1701