The cerebral critical oxygen threshold of ventilated preterm lambs and the influence of antenatal inflammation

Journal of Applied Physiology

Volumn 111, Issue 3, 2011, Pages 775-781

  Andersen, C C ^a   Pillow, J J ^b   Gill, A W ^b   Allison, B J ^c,d   Moss, T J M ^c,d   Hooper, S B ^c,d   Nitsos, I ^b,c   Kluckow, M ^e   Polglase, G R ^c,d  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Brain injury; Chorioamnionitis; Oxygen consumption; Premature

Indexed keywords

LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE, E COLI O55 B5; LIPOPOLYSACCHARIDE, E COLI O55-B5; OXYGEN;

ANIMAL; ARTICLE; ARTIFICIAL VENTILATION; BLOOD; BLOOD FLOW; BRAIN; BRAIN CIRCULATION; CAROTID ARTERY; CHEMICALLY INDUCED DISORDER; CHORIOAMNIONITIS; DISEASE MODEL; FEMALE; GESTATIONAL AGE; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOLOGY; INFLAMMATION; KINETICS; LUNG CIRCULATION; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PREGNANCY; PREMATURITY; SHEEP; VASCULARIZATION;

ANIMALS; BRAIN; CAROTID ARTERIES; CEREBROVASCULAR CIRCULATION; CHORIOAMNIONITIS; DISEASE MODELS, ANIMAL; FEMALE; GESTATIONAL AGE; HYPOXIA-ISCHEMIA, BRAIN; INFLAMMATION; KINETICS; LIPOPOLYSACCHARIDES; OXYGEN; OXYGEN CONSUMPTION; PREGNANCY; PREMATURE BIRTH; PULMONARY CIRCULATION; REGIONAL BLOOD FLOW; RESPIRATION, ARTIFICIAL; SHEEP;

EID: 80053025451     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00214.2011     Document Type: Article

References (43)

1. Abdulkadir AA, Kimimasa T, Bell MJ, Macpherson TA, Keller BB, Yanowitz TD. Placental inflammation and fetal hemodynamics in a rat model of chorioamnionitis. Pediatr Res. In press.
2. Bachurski CJ, Ross GF, Ikegami M, Kramer BW, Jobe AH. Intraamniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheep. Am J Physiol Lung Cell Mol Physiol 280: L279-L285, 2001.
3. Bauer J, Hentschel R, Linderkamp O. Effect of sepsis syndrome on neonatal oxygen consumption and energy expenditure. Pediatrics 110: e69, 2002.
4. Berger R, Lehmann T, Karcher J, Schachenmayr W, Jensen A. Relation between cerebral oxygen delivery and neuronal cell damage in fetal sheep near term. Reprod Fertil Dev 8: 317-321, 1996. (Pubitemid 26193757)
5. Borch K, Greisen G. Blood flow distribution in the normal human preterm brain. Pediatr Res 43: 28-33, 1998. (Pubitemid 28069164)
6. Crossley KJ, Morley CJ, Allison BJ, Davis PG, Polglase GR, Wallace MJ, Zahra VA, Hooper SB. Antenatal corticosteroids increase fetal, but not postnatal, pulmonary blood flow in sheep. Pediatr Res 66: 283-288, 2009.
7. Crossley KJ, Morley CJ, Allison BJ, Polglase GR, Dargaville PA, Harding R, Hooper SB. Blood gases and pulmonary blood flow during resuscitation of very preterm lambs treated with antenatal betamethasone and/or Curosurf: effect of positive end-expiratory pressure. Pediatr Res 62: 37-42, 2007. (Pubitemid 46985847)
8. de Waal KA, Evans N, Osborn DA, Kluckow M. Cardiorespiratory effects of changes in end expiratory pressure in ventilated newborns. Arch Dis Child Fetal Neonatal Ed 92: F444-F448, 2007. (Pubitemid 350044000)
9. Del Toro J, Louis PT, Goddard-Finegold J. Cerebrovascular regulation and neonatal brain injury. Pediatr Neurol 7: 3-12, 1991.
10. Duncan JR, Cock ML, Scheerlinck JP, Westcott KT, McLean C, Harding R, Rees SM. White matter injury after repeated endotoxin exposure in the preterm ovine fetus. Pediatr Res 52: 941-949, 2002. (Pubitemid 35379477)
11. Elimian A, Verma U, Beneck D, Cipriano R, Visintainer P, Tejani N. Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. Obstet Gynecol 96: 333-336, 2000.
12. Ellison VJ, Mocatta TJ, Winterbourn CC, Darlow BA, Volpe JJ, Inder TE. The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn. Pediatr Res 57: 282-286, 2005. (Pubitemid 40165609)
13. Grether JK, Nelson KB. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA 278: 207-211, 1997. (Pubitemid 27339585)
14. Inder TE, Warfield SK, Wang H, Huppi PS, Volpe JJ. Abnormal cerebral structure is present at term in premature infants. Pediatrics 115: 286-294, 2005. (Pubitemid 43193809)
15. Jobe A, Jacobs H, Ikegami M, Berry D. Lung protein leaks in ventilated lambs: effects of gestational age. J Appl Physiol 58: 1246-1251, 1985. (Pubitemid 15033189)
16. Kallapur SG, Bachurski CJ, Le Cras TD, Joshi SN, Ikegami M, Jobe AH. Vascular changes after intra-amniotic endotoxin in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol 287: L1178-L1185, 2004. (Pubitemid 39507195)
17. Kallapur SG, Jobe AH, Ball MK, Nitsos I, Moss TJ, Hillman NH, Newnham JP, Kramer BW. Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis. J Immunol 179: 8491-8499, 2007.
18. Keramidaris E, Hooper SB, Harding R. Effect of gestational age on the increase in fetal lung growth following tracheal obstruction. Exp Lung Res 22: 283-298, 1996. (Pubitemid 26187247)
19. Kern JW, Shoemaker WC. Meta-analysis of hemodynamic optimization in high-risk patients. Crit Care Med 30: 1686-1692, 2002. (Pubitemid 34879575)
20. Khwaja O, Volpe JJ. Pathogenesis of cerebral white matter injury of prematurity. Arch Dis Child Fetal Neonatal Ed 93: F153-F161, 2008. (Pubitemid 352038509)
21. Kissack CM, Garr R, Wardle SP, Weindling AM. Cerebral fractional oxygen extraction in very low birth weight infants is high when there is low left ventricular output and hypocarbia but is unaffected by hypotension. Pediatr Res 55: 400-405, 2004. (Pubitemid 38240816)
22. Kissack CM, Garr R, Wardle SP, Weindling AM. Cerebral fractional oxygen extraction is inversely correlated with oxygen delivery in the sick, newborn, preterm infant. J Cereb Blood Flow Metab 25: 545-553, 2005. (Pubitemid 40562928)
23. Kissack CM, Garr R, Wardle SP, Weindling AM. Postnatal changes in cerebral oxygen extraction in the preterm infant are associated with intraventricular hemorrhage and hemorrhagic parenchymal infarction but not periventricular leukomalacia. Pediatr Res 56: 111-116, 2004. (Pubitemid 38808551)
24. Kluckow M. Low systemic blood flow and pathophysiology of the preterm transitional circulation. Early Hum Dev 81: 429-437, 2005. (Pubitemid 40791133)
25. Kluckow M, Evans N. Low superior vena cava flow and intraventricular haemorrhage in preterm infants. Arch Dis Child Fetal Neonatal Ed 82: F188-F194, 2000. (Pubitemid 30313552)
26. Kramer BW, Moss TJ, Willet KE, Newnham JP, Sly PD, Kallapur SG, Ikegami M, Jobe AH. Dose and time response after intraamniotic endotoxin in preterm lambs. Am J Respir Crit Care Med 164: 982-988, 2001. (Pubitemid 32971645)
27. Kreymann G, Grosser S, Buggisch P, Gottschall C, Matthaei S, Greten H. Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med 21: 1012-1019, 1993. (Pubitemid 23206193)
28. Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 42: 145-151, 2008.
29. Meadow W, Rudinsky B, Raju T, John E, Fornell L, Shankararao R. Correlation of flow probe determinations of common carotid artery blood flow and internal carotid artery blood flow with microsphere determinations of cerebral blood flow in piglets. Pediatr Res 45: 324-330, 1999. (Pubitemid 29157762)
30. Moessinger AC, Harding R, Adamson TM, Singh M, Kiu GT. Role of lung fluid volume in growth and maturation of the fetal sheep lung. J Clin Invest 86: 1270-1277, 1990. (Pubitemid 20370434)
31. Moss TJ, Nitsos I, Kramer BW, Ikegami M, Newnham JP, Jobe AH. Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep. Am J Obstet Gynecol 187: 1059-1065, 2002. (Pubitemid 35178411)
32. Nitsos I, Rees SM, Duncan J, Kramer BW, Harding R, Newnham JP, Moss TJ. Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain. J Soc Gynecol Investig 13: 239-247, 2006. (Pubitemid 43668396)
33. Nunn JF. Applied Respiratory Physiology. London: Butterworths, 1987.
34. Polglase GR, Hooper SB, Gill AW, Allison BJ, Crossley KJ, Moss TJ, Nitsos I, Pillow JJ, Kluckow M. Intrauterine inflammation causes pulmonary hypertension and cardiovascular sequelae in preterm lambs. J Appl Physiol 108: 1757-1765, 2010.
35. Polglase GR, Hooper SB, Gill AW, Allison BJ, Crossley KJ, Moss TJ, Nitsos I, Pillow JJ, Kluckow M. Intrauterine inflammation causes pulmonary hypertension and cardiovascular sequelae in preterm lambs. J Appl Physiol 108: 1757-1765, 2010.
36. Polglase GR, Hooper SB, Gill AW, Allison BJ, McLean CJ, Nitsos I, Pillow JJ, Kluckow M. Cardiovascular and pulmonary consequences of airway recruitment in preterm lambs. J Appl Physiol 106: 1347-1355, 2009.
37. Polglase GR, Morley CJ, Crossley KJ, Dargaville P, Harding R, Morgan DL, Hooper SB. Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs. J Appl Physiol 99: 1453-1461, 2005. (Pubitemid 43014354)
38. Saito M, Matsuda T, Okuyama K, Kobayashi Y, Kitanishi R, Hanita T, Okamura K. Effect of intrauterine inflammation on fetal cerebral hemodynamics and white-matter injury in chronically instrumented fetal sheep. Am J Obstet Gynecol 200: 663.e1-663.e11, 2009.
39. Squara P. Matching total body oxygen consumption and delivery: a crucial objective? Intensive Care Med 30: 2170-2179, 2004. (Pubitemid 40174252)
40. van Bel F, Roman C, Klautz RJ, Teitel DF, Rudolph AM. Relationship between brain blood flow and carotid arterial flow in the sheep fetus. Pediatr Res 35: 329-333, 1994. (Pubitemid 24064606)
41. West CR, Groves AM, Williams CE, Harding JE, Skinner JR, Kuschel CA, Battin MR. Early low cardiac output is associated with compromised electroencephalographic activity in very preterm infants. Pediatr Res 59: 610-615, 2006. (Pubitemid 43740066)
42. Yan EB, Baburamani AA, Walker AM, Walker DW. Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord. Am J Physiol Regul Integr Comp Physiol 297: R60-R69, 2009.
43. Yoon BH, Park CW, Chaiworapongsa T. Intrauterine infection and the development of cerebral palsy. BJOG 110, Suppl 20: 124-127, 2003. (Pubitemid 36577401)