Antenatal corticosteroids increase fetal, but not postnatal, pulmonary blood flow in sheep

Pediatric Research

Volumn 66, Issue 3, 2009, Pages 283-288

  Crossley, Kelly J ^a   Morley, Colin J ^b,c   Allison, Beth J ^a   Davis, Peter G ^b   Polglase, Graeme R ^d   Wallace, Megan J ^a   Zahra, Valerie A ^a   Hooper, Stuart B ^a  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; VASCULOTROPIN; GLUCOCORTICOID; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; FETUS LUNG MATURATION; GAS EXCHANGE; HEART RATE; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP; ANIMAL; BLOOD FLOW; DRUG EFFECT; LUNG CIRCULATION; METABOLISM; NEWBORN; PHYSIOLOGY; PREGNANCY; PULMONARY ARTERY;

ANIMALS; ANIMALS, NEWBORN; BETAMETHASONE; FEMALE; FETUS; GLUCOCORTICOIDS; NITRIC OXIDE SYNTHASE TYPE III; PREGNANCY; PULMONARY ARTERY; PULMONARY CIRCULATION; REGIONAL BLOOD FLOW; SHEEP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70350441381     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181b1bc5d     Document Type: Article

References (36)

1. Liggins GC, Howie RN 1972 A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 50:515-525
2. Crowley PA 1995 Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol 173:322-335
3. Jobe AH, Mitchell BR, Gunkel JH 1993 Beneficial effects of the combined use of prenatal corticosteroids and postnatal surfactant on preterm, infants. Am J Obstet Gynecol 168:508-513
4. Wallace MJ, Hooper SB, Harding R 1995 Effects of elevated fetal Cortisol concentrations on the volume, secretion, and reabsoiption of lung liquid. Am J Physiol 269:R881-R887
5. Heymann MA 1984 Control of the pulmonary circulation in the perinatal period. J Dev Physiol 6:281-290
6. Polglase GR, Wallace MJ, Grant DA, Hooper SB 2004 Influence of fetal breathing movements on pulmonary hemodynamics in fetal sheep. Pediatr Res 56:932-938
7. Rudolph AM 1979 Fetal and neonatal pulmonary circulation. Annu Rev Physiol 41:383-395
8. Polglase GR, Morley CJ, Crossley KJ, Dargaville P, Harding R, Morgan DL, Hooper SB 2005 Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs. J Appl Physiol 99:1453-1461
9. Crossley KJ, Morley CJ, Allison BJ, Polglase GR, Dargaville PA, Harding R, Hooper SB 2007 Blood gases and pulmonary blood flow during resuscitation of very preterm lambs treated with antenatal betamethasone and/or Curosuif: effect of positive end-expiratory pressure. Pediatr Res 62:37-42
10. Reid DL, Thornburg KL 1990 Pulmonary pressure-flow relationships in the fetal lamb during in utero ventilation. J Appl Physiol 69:1630-1636
11. Thebaud B, Abman SH 2007 Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease. Am J Respir Crit Care Med 175:978-985
12. Yu VY 1993 Persistent pulmonary hypertension in the newborn. Early Hum Dev 33:163-175
13. De Matteo R, May CN 1999 Inhibition of prostaglandin and nitric oxide synthesis prevents cortisol-induced renal vasodilatation in sheep. Am J Physiol 276:R1125-R1131
14. Wallace EM, Baker LS 1999 Effect of antenatal betamethasone administration on placental vascular resistance. Lancet 353:1404-1407
15. Miller SL, Chai M, Loose J, Castillo-Melendez M, Walker DW, Jenkin G, Wallace EM 2007 The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology 148:1288-1295
16. Moraga FA, Riquelme RA, Lopez AA, Moya FR, Llanos AJ 1994 Maternal administration of glucocorticoid and thyrotropin-releasing hormone enhances fetal lung maturation in undisturbed preterm lambs. Am J Obstet Gynecol 171:729-734
17. Ikegami M, Jobe AH, Newnham J, Polk DH, Willet KE, Sly P 1997 Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med 156:178-184
18. Teitel DF, Iwamoto HS, Rudolph AM 1990 Changes in the pulmonary circulation during birth-related events. Pediatr Res 27:372-378
19. Edwards A, Baker LS, Wallace EM 2003 Changes in umbilical artery flow velocity waveforms following maternal administration of betamethasone. Placenta 24:12-16
20. Clifton VL, Wallace EM, Smith R 2002 Short-term effects of glucocorticoids in the human fetal-placental circulation in. vitro. J Clin Endocrinol Metab 87:2838-2842
21. Potter SM, Dennedy MC, Morrison JJ 2002 Corticosteroids and fetal vasculature: effects of hydrocortisone, dexamethasone, and betamethasone on human umbilical artery. BJOG 109:1126-1131
22. Moise AA, Wearden ME, Kozinetz CA, Gest AL, Welty SE, Hansen TN 1995 Antenatal steroids are associated with less need for blood pressure support in extremely premature infants. Pediatrics 95:845-850
23. Docherty CC, Kalmar-Nagy J, Engelen M, Koenen SV, Nijland M, Kuc RE, Davenport AP, Nathanielsz PW 2001 Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1. Am J Physiol Regul Integr Comp Physiol 281:R261-R268
24. Gao Y, Tolsa JF, Shen H, Raj JU 1998 A single dose of antenatal betamethasone enhances isoprenaline and prostaglandin E2-induced relaxation of preterm ovine pulmonary arteries. Biol Neonate 73:182-189
25. Deruelle P, Houfflin-Debarge V, Magnenant E, Jaillard S, Riou Y, Puech F, Storme L 2003 Effects of antenatal glucocorticoids on pulmonary vascular reactivity in the ovine fetus. Am J Obstet Gynecol 189:208-215
26. Zhou H, Gao Y, Raj JU 1996 Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins. J Appl Physiol 80:390-396
27. Houfflin-Debarge V, Deruelle P, Jaillard S, Magnenant E, Riou Y, Devisme L, Puech F, Storme L 2005 Effects of antenatal glucocorticoids on circulatory adaptation at birth in the ovine fetus. Biol Neonate 88:73-78
28. Alcorn DG, Adamson TM, Maloney JE, Robinson PM 1981 A morphologic and morphometric analysis of fetal lung development in the sheep. Anat Rec 201:655-667
29. Cabral AC, Pereira AK, Rodrigues RL 2006 Assessment of fetal pulmonary artery flow by Doppler echocardiography after antenatal corticoid therapy. Int J Gynaecol Obstet 92:257-259
30. Abman SH 2004 Developmental physiology of the pulmonary circulation. In: Harding R, Pinkerton KE, Plopper CG (eds) The Lung: Development, Aging, and the Environment. Butterwoith Heinemann, Oxford, pp 105-117
31. Suzuki K, Hooper SB, Wallace MJ, Probyn ME, Harding R 2006 Effects of antenatal corticosteroid treatment on pulmonary ventilation and circulation in neonatal lambs with hypoplastic lungs. Pediatr Pulmonol 41:844-854
32. Dawes GS 1968 Fetal and Neonatal Physiology. Year Book Inc., Chicago, IL
33. Hooper SB, Harding R 2005 Role of aeration in the physiological adaptation of the lung to air-breathing at birth. Curr Resp Med Rev 1:185-195
34. Ikegami M, Polk DH, Jobe AH, Newnham J, Sly P, Kohan R, Kelly R 1996 Effect of interval from fetal corticosteroid treatment to delivery on postnatal lung function of preterm lambs. J Appl Physiol 80:591-597
35. Willet KE, Jobe AH, Ikegami M, Newnham J, Brennan S, Sly PD 2000 Antenatal endotoxin, and glucocorticoid effects on lung morphometry in preterm lambs. Pediatr Res 48:782-788
36. Massaro GD, Massaro D 1992 Formation of alveoli in rats: postnatal effect of prenatal dexamethasone. Am J Physiol 263:L37-L41