Hypoglycemia in sepsis: Biomarker, mediator, or both?

Critical Care Medicine

Volumn 39, Issue 10, 2011, Pages 2367-2369

  Bellomo, Rinaldo ^a,b   Egi, Moritoki ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

glucose; hyperglycemia; hypoglycemia; sepsis

Indexed keywords

BIOLOGICAL MARKER; INSULIN;

BACTERICIDAL ACTIVITY; BLOOD GLUCOSE MONITORING; CHEMOTAXIS; CRITICALLY ILL PATIENT; CYTOKINE RESPONSE; DISEASE SEVERITY; EDITORIAL; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; HYPERGLYCEMIA; HYPERMETABOLISM; HYPEROSMOLARITY; HYPOGLYCEMIA; INSULIN RESISTANCE; INSULIN TREATMENT; INTENSIVE CARE; MALARIA; MENTAL HEALTH; META ANALYSIS (TOPIC); METABOLIC REGULATION; MORTALITY; PHAGOCYTOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEPSIS;

EID: 80052982245     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31822a5be5     Document Type: Editorial

References (30)

1. McCowen KC, Malhotra A, Bistrian BR: Stress-induced hyperglycemia. Crit Care Clin 2001; 17:107-124 (Pubitemid 32163181)
2. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
3. Mizock BA: Alterations in carbohydrate metabolism during stress: A review of the literature. Am J Med 1995; 98:75-84
4. Khaodhiar L, McCowen K, Bistrian B: Perioperative hyperglycemia, infection or risk? Curr Opin Clin Nutr Metab Care 1999; 2:79-82
5. Finney SJ, Zekveld C, Elia A, et al: Glucose control and mortality in critically ill patients. JAMA 2003; 290:2041-2047 (Pubitemid 37430587)
6. Krinsley JS: Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003; 78:1471-1478 (Pubitemid 37475630)
7. Bagdade JD, Stewart M, Walters E: Impaired granulocyte adherence. A reversible defect in host defense in patients with poorly controlled diabetes. Diabetes 1978; 27:677-681 (Pubitemid 8370534)
8. Mowat A, Baum J: Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. N Engl J Med 1971; 284: 621-627
9. Latham R, Lancaster AD, Covington JF, et al: The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 2001; 22:607-612 (Pubitemid 33152102)
10. Van den Berghe G, Wouters PJ, Bouillon R, et al: Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 2003; 31:359-366 (Pubitemid 36232926)
11. Dellinger RP, Carlet JM, Masur H, et al: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873 (Pubitemid 38344143)
12. Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
13. Van den Berghe G, Wilmer A, Milants I, et al: Intensive insulin therapy in mixed medical/surgical intensive care units: Benefit versus harm. Diabetes 2006; 55:3151-3159 (Pubitemid 44923655)
14. Bagshaw SM, Bellomo R: The need to reform our assessment of evidence from clinical trials: A commentary. Philos Ethics Humanit Med 2008; 3:23
15. Egi M, Bellomo R, Stachowski E, et al: Intensive insulin therapy in postoperative intensive care unit patients: A decision analysis. Am J Respir Crit Care Med 2006; 173: 407-413 (Pubitemid 43228328)
16. Brunkhorst FM, Engel C, Bloos F, et al: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
17. Preiser JC, Devos P, Ruiz-Santana S, et al: A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol study. Intensive Care Med 2009; 35:1738-1748
18. Finfer S, Heritier S, NICE Study Management Committee and SUGAR Study Executive Committee: The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: Statistical analysis plan. Crit Care Resusc 2009; 11:46-57
19. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297
20. Griesdale DE, de Souza RJ, van Dam RM, et al: Intensive insulin therapy and mortality among critically ill patients: A meta-analysis including NICE-SUGAR study data. CMAJ 2009; 180:821-827
21. Egi M, Bellomo R, Stachowski E, et al: Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc 2010; 85:217-224
22. Ssekitoleko R, Jacob ST, Banura P, et al: Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis. Crit Care Med 2011; 39:2271-2276
23. Dotson S, Freeman R, Failing HJ, et al: Hypoglycemia increases serum interleukin-6 levels in healthy men and women. Diabetes Care 2008; 31:1222-1223
24. Schlenk F, Graetz D, Nagel A, et al: Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage. Crit Care 2008; 12:R9
25. Keller-Wood ME, Shinsako J, Dallman MF: Inhibition of the adrenocorticotropin and corticosteroid responses to hypoglycemia after prior stress. Endocrinology 1983; 113:491-496 (Pubitemid 13048936)
26. Herlein JA, Morgan DA, Phillips BG, et al: Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses. Endocrinology 2006; 147: 2781-2788 (Pubitemid 43764615)
27. Diéguez G, Fernández N, García JL, et al: Role of nitric oxide in the effects of hypoglycemia on the cerebral circulation in awake goats. Eur J Pharmacol 1997; 330:185-193 (Pubitemid 27296721)
28. Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 1993; 91:819-828 (Pubitemid 23095255)
29. Bellomo R, Egi M: What is a NICE-SUGAR for patients in the intensive care unit? Mayo Clin Proc 2009; 84:400-402
30. Maitland K, Kiguli S, Opoka RO, et al: Mortality after fluid bolus in African children with severe infection. N Engl J Med 2011; 364:2483-2495