Human myeloid dendritic cells are refractory to tryptophan metabolites

Human Immunology

Volumn 72, Issue 10, 2011, Pages 791-797

  Von Bubnoff, Dagmar ^a   Wilms, Helene ^a   Scheler, Marina ^a   Brenk, Manuela ^a   Koch, Susanne ^a   Bieber, Thomas ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Dendritic cells; Indoleamine 2,3 dioxygenase; Tryptophan metabolites

Indexed keywords

3 HYDROXYANTHRANILIC ACID; 3 HYDROXYKYNURENINE; ANTHRANILIC ACID; IMMUNOGLOBULIN LIKE TRANSCRIPT 2; IMMUNOGLOBULIN LIKE TRANSCRIPT 3; IMMUNOGLOBULIN LIKE TRANSCRIPT 4; IMMUNOGLOBULIN RECEPTOR; KYNURENINE; QUINOLINIC ACID; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE ACTIVATION; METABOLITE; MONOCYTE; MYELOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANTIBODIES; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DENDRITIC CELLS; FLOW CYTOMETRY; HUMANS; IMMUNITY, CELLULAR; IMMUNOHISTOCHEMISTRY; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KYNURENINE; LYMPHOCYTE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MONOCYTES; QUINOLINIC ACID; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES, REGULATORY; TRYPTOPHAN;

EID: 80052970536     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.05.026     Document Type: Article

References (36)

1. Mellor A.L., Munn D.H. IDO expression by dendritic cells: Tolerance and tryptophan catabolism. Nat Rev Immunol 2004, 4:762-774.
2. Baban B., Chandler P., McCool D., Marshall B., Munn D.H., Mellor A.L. Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol 2004, 61:67-77.
3. Uyttenhove C., Pilotte L., Théate I., Stroobant V., Colau D., Parmentier, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003, 9:1269-1274.
4. + T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol 2004, 172:4100-4110.
5. Grohmann U., Orabona C., Fallarino F., Vacca C., Calcinaro F., Falorni, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002, 3:1097-1101.
6. Gu T., Rowswell-Turner R.B., Kilinc M.O., Egilmez N.K. Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Res 2010, 70:129-138.
7. von Bubnoff D., Matz H., Frahnert C., Rao M.L., Hanau D., et al. RI induces the tryptophan degradation pathway involved in regulating T-cell responses. J Immunol 2002, 169:1810-1816.
8. Puccetti P. On watching the watchers: IDO and type I/II IFN. Eur J Immunol 2007, 37:876-879.
9. Royer P.J., Emara M., Yang C., Al-Ghouleh A., Tighe P., et al. The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T-cell polarization through modulation of IDO activity. J Immunol 2010, 185:1522-1531.
10. Muller A.J., DuHadaway J.B., Chang M.Y., Ramalingam A., Sutanto-Ward E., Boulden, et al. Non-hematopoietic expression of IDO is integrally required for inflammatory tumor promotion. Cancer Immunol Immunother 2010, 59:1655-1663.
11. Scheler M., Wenzel J., Tüting T., Takikawa O., Bieber T., von Bubnoff D. Indoleamine 2,3-dioxygenase (IDO): The antagonist of type I interferon-driven skin inflammation?. Am J Pathol 2007, 171:1936-1943.
12. +CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol 2007, 37:3054-3062.
13. Li Y., Tredget E.E., Ghahary A. Cell surface expression of MHC class I antigen is suppressed in indoleamine 2,3-dioxygenase genetically modified keratinocytes: Implications in allogeneic skin substitute engraftment. Hum Immunol 2004, 65:114-123.
14. Munn D.H., Sharma M.D., Baban B., Harding H.P., Zhang Y., et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005, 22:633-642.
15. Terness P., Bauer T.M., Röse L., Dufter C., Watzlik A., et al. Inhibition of allogeneic T-cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: Mediation of suppression by tryptophan metabolites. J Exp Med 2002, 196:447-457.
16. Fallarino F., Grohmann U., You S., McGrath B.C., Vacca D.R., Cavener, et al. Tryptophan catabolism generates autoimmune-preventive regulatory T cells. Transpl Immunol 2006, 17:58-60.
17. Brenk M., Scheler M., Koch S., Neumann J., Takikawa O., Hacker G., et al. Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells. J Immunol 2009, 183:145-154.
18. Ristich V., Liang S., Zhang W., Wu J., Horuzsko A. Tolerization of dendritic cells by HLA-G. Eur J Immunol 2005, 35:1133-1142.
19. Belladonna M.L., Grohmann U., Guidetti P., Volpi C., Bianchi R., Fioretti M., et al. Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO. J Immunol 2006, 177:130-137.
20. von Bubnoff D., Scheler M., Hinz T., Matz H., Koch S., Bieber T. Comparative immunophenotyping of monocytes from symptomatic and asymptomatic atopic individuals. Allergy 2004, 59:933-939.
21. Kraft S., Wessendorf J.H., Hanau D., Bieber T. Regulation of the high affinity receptor for IgE on human epidermal Langerhans cells. J Immunol 1998, 161:1000-1006.
22. Haniffa M.A., Wang X.N., Holtick U., Rae M., Isaacs J.D., Dickinson A.M., et al. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 2007, 179:1595-1604.
23. Terness P., Chuang J.J., Opelz G. The immunoregulatory role of IDO-producing human dendritic cells revisited. Trends Immunol 2006, 27:68-73.
24. Jung I.D., Lee M.G., Chang J.H., Lee J.S., Jeong Y.I., Lee C.M., et al. Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock. J Immunol 2009, 182:3146-3154.
25. Baban B., Hansen A.M., Chandler P.R., Manlapat A., Bingaman A., Kahler D.J., et al. A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T-cell suppression via type I IFN signaling following B7 ligation. Int Immunol 2005, 17:909-919.
26. Bozza S., Fallarino F., Pitzurra L., Zelante T., Montagnoli C., Bellocchio, et al. A crucial role for tryptophan catabolism at the host/Candida albicans interface. J Immunol 2005, 174:2910-2918.
27. Weber W.P., Feder-Mengus C., Chiarugi A., Rosenthal R., Reschner A., Schumacher Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines. Eur J Immunol 2006, 36:296-304.
28. Fallarino F., Grohmann U., You S., McGrath B.C., Cavener D.R., Vacca, et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T-cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006, 176:6752-6761.
29. Platten M., Ho P.P., Youssef S., Fontoura P., Garren H., Hur E.M., et al. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science 2005, 310:850-855.
30. Boasso A. Wounding the immune system with its own blade: HIV-induced tryptophan catabolism and pathogenesis. Curr Med Chem 2011, 18:2247-2255.
31. Tattevin P., Monnier D., Tribut O., Dulong J., Bescher N., Mourcin, et al. Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock. J Infect Dis 2010, 201:956-966.
32. Moffett J.R., Namboodiri M.A. Tryptophan and the immune response. Immunol Cell Biol 2003, 81:247-265.
33. Werner E.R., Hirsch-Kauffmann M., Fuchs D., Hausen A., Reibnegger G., Schweiger, et al. Interferon-gamma-induced degradation of tryptophan by human cells in vitro. Biol Chem Hoppe Seyler 1987, 368:1407-1412.
34. Allegri G., Bertazzo A., Biasiolo M., Costa C.V., Ragazzi E. Kynurenine pathway enzymes in different species of animals. Adv Exp Med Biol 2003, 527:455-463.
35. Allegri G., Ragazzi E., Bertazzo A., Costa C.V. Enzyme activities along the kynurenine pathway in mice. Adv Exp Med Biol 2003, 527:497-510.
36. Schroecksnadel K., Zangerle R., Bellmann-Weiler R., Garimorth K., Weiss G., Fuchs D. Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infection. Curr Drug Metab 2007, 8:225-236.