Willingness to participate in biomedical HIV prevention studies after the HVTN 503/phambili trial: A survey conducted among adolescents in Soweto, South Africa

Journal of Acquired Immune Deficiency Syndromes

Volumn 58, Issue 2, 2011, Pages 211-218

  Otwombe, Kennedy N ^a   Sikkema, Kathleen J ^a   Dietrich, Janan ^a   De Bruyn, Guy ^a   Van Der Watt, Martin ^a   Gray, Glenda E ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

biomedical; HIV prevention; HVTN 503 Phambili trial; willingness to participate

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOMEDICINE; FEMALE; HEALTH SURVEY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; PATIENT ATTITUDE; PRIORITY JOURNAL; PSYCHOSOCIAL DEVELOPMENT; SEXUAL BEHAVIOR; SEXUALITY; SOUTH AFRICA; SUBSTANCE ABUSE;

ADOLESCENT; AIDS VACCINES; CLINICAL TRIALS AS TOPIC; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; LIFE CHANGE EVENTS; LOGISTIC MODELS; MALE; PATIENT PARTICIPATION; SELF EFFICACY; SEX FACTORS; SEXUAL BEHAVIOR; SEXUAL PARTNERS; SOUTH AFRICA;

EID: 80052970119     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31822b7702     Document Type: Article

References (41)

1. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-1174.
2. Buchbinder SP, Liu A. Pre-exposure prophylaxis and the promise of combination prevention approaches. AIDS Behav. 2011;15(suppl 1): S72-S79.
3. Rudy BJ, Kapogiannis BG, Lally MA, et al. Youth-specific considerations in the development of preexposure prophylaxis, microbicide and vaccine research trials. J Acquir Immune Defic Syndr. 2010;54:S31-S42.
4. Tobian AA, Serwadda D, Quinn TC, et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med. 2009;360:1298-1309.
5. Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009;361:2209-2220.
6. Gray GE, Allen M, Moodie Z, et al. Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis. 2011;11:507-515.
7. de Bruyn G. Cofactors that may influence vaccine responses. Curr Opin HIV AIDS. 2010;5:404-408.
8. Gray G, Buchbinder S, Duerr A. Overview of STEP and HVTN 503/Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine. Curr Opin HIV AIDS. 2010;5:357-361.
9. Buchbinder SP, Mehrotra DV, Duerr A, et al. Efficacy assessment of a cellmediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372: 1881-1893.
10. Bansal G, Malaspina A, Flores J. Future paths for HIV vaccine research: exploiting results from recent clinical trials and current scientific advances. Curr Opin Mol Ther. 2010;12:39-46.
11. Colfax G, Buchbinder S, Vamshidar G, et al. Motivations for participating in an HIV vaccine efficacy trial. J Acquir Immune Defic Syndr. 2005;39: 359-364. (Pubitemid 40923219)
12. UNAIDS. 2010 Report on the Global AIDS Epidemic. Geneva, Switzerland: UNAIDS; 2010.
13. Shisana O, Rehle T, Simbayi LC, et al. South African National HIV Prevalence, Incidence, Behaviour and Communication Survey 2008: A Turning Tide Among Teenagers? Cape Town, South Africa: HSRC Press.
14. Pettifor AE, Rees HV, Kleinschmidt I, et al. Young people's sexual health in South Africa: HIV prevalence and sexual behaviors from a nationally representative household survey. AIDS. 2005;19:1525-1534. (Pubitemid 41400699)
15. Wilson CM, Wright PF, Safrit JT, et al. Epidemiology of HIV infection and risk in adolescents and youth. J Acquir Immune Defic Syndr. 2010;54:S5-S6.
16. Kapogiannis BG, Handelsman E, Ruiz MS, et al. Introduction: paving the way for biomedical HIV prevention interventions in youth. J Acquir Immune Defic Syndr. 2010;54:S1-S4.
17. Jewkes R, Nduna M, Levin J, et al. Impact of stepping stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa: cluster randomised controlled trial. BMJ. 2008;337:a506.
18. Pettifor A, O'Brien K, Macphail C, et al. Early coital debut and associated HIV risk factors among young women and men in South Africa. Int Perspect Sex Reprod Health. 2009;35:82-90.
19. Allen MA, Liang TS, La Salvia T, et al. Assessing the attitudes, knowledge and awareness of HIV vaccine research among adults in the United States. J Acquir Immune Defic Syndr. 2005;40:617-624. (Pubitemid 41669168)
20. Hosek SG, Zimet GD. Behavioral considerations for engaging youth in HIV clinical research. J Acquir Immune Defic Syndr. 2010;54:S25-S30.
21. McClure C, Gray G, Rybczyk K, et al. Challenges to conducting HIV preventative vaccine trials with adolescents. J Acquir Immune Defic Syndr. 2004;36:726-733. (Pubitemid 38685967)
22. DiClemente RJ, Ruiz MS, Sales JM. Barriers to adolescent's participation in HIV biomedical prevention research. J Acquir Immune Defic Syndr. 2010;54:S12-S17.
23. Smit J, Middelkoop K, Myer L, et al. Willingness to participate in HIV vaccine research in a peri-urban South African community. Int J STD AIDS. 2006;17:176-179.
24. Grinstead OA. Social and behavioral issues in phase III HIV preventive vaccine trials. AIDS. 1995;9:S245-S250.
25. de Bruyn G, Skhosana N, Robertson G, et al. Knowledge and attitudes towards HIV vaccines among Soweto adolescents. BMC Research Notes. 2008;1:76.
26. DiClemente RJ, Wingwood GM, Crosby R, et al. Parent-adolescent communication and sexual risk behaviours among African American adolescent females. J Pediatr. 2001;139:407-412. (Pubitemid 32889518)
27. Sayles JN, Pettifor AE, Wong MD, et al. Factors associated with selfefficacy for condom use and sexual negotiation among South African youth. J Acquir Immune Defic Syndr. 2006;43:226-233. (Pubitemid 44454818)
28. Hendriksen ES, Pettifor AE, Lee SJ, et al. Predictors of condom use among young adults in South Africa: the reproductive health and HIV research unit national youth survey. Am J Public Health. 2007;97: 1241-1248. (Pubitemid 351182354)
29. Spirito A, Stark LJ, Williams C. Development of a brief coping checklist for use with pediatric populations. J Pediatr Psychol. 1988;13:555-574.
30. Hosmer DW, Lemeshow S. Applied Logistic Regression. 2nd ed. Hoboken, NJ: John Wiley and Sons; 2000.
31. Jaspan HB, Berwick JR, Myer L, et al. Adolescent HIV prevalence, sexual risk and willingness to participate in HIV vaccine trials. J Adolesc Health. 2006;39:642-648. (Pubitemid 44529028)
32. Kiwanuka N, Robb M, Kigozi G, et al. Knowledge about vaccines and willingness to participate in preventive HIV vaccine trials. J Acquir Immune Defic Syndr. 2004;36:721-725. (Pubitemid 38685966)
33. Middelkoop K, Myer L, Mark D, et al. Adolescent and adult participation in an HIV vaccine trial preparedness cohort in South Africa. J Adolesc Health. 2008;43:8-14.
34. Newman P, Logie C. HIV vaccine acceptability: a systematic review and meta-analysis. AIDS. 2010;24:1749-1756.
35. Smit J, Middelkoop K, Myer L, et al. Socio-behaviour challenges to phase III HIV vaccine trials in Sub-Saharan Africa. Afr Health Sci. 2005;5: 198-206.
36. Meyers K, Metzger DS, Navaline H, et al. HIV vaccine trials: will intravenous drug users enroll? Am J Public Health. 1994;84:761-766. (Pubitemid 24237353)
37. O'Connell JM, Hogg RS, Chan K, et al. Willingness to participate and enroll in a phase 3 preventive HIV-1 vaccine trial. J Acquir Immune Defic Syndr. 2002;31:521-528. (Pubitemid 35448660)
38. Etcheverry MF, Lum PJ, Evans JL, et al. HIV vaccine trial willingness among injection and non-injection drug users in two urban centres, Barcelona and San Francisco. Vaccine. 2011;29:1991-1996.
39. Auvert B, Buve A, Lagarde E, et al. Male circumcision and HIV infection in four cities in sub-Saharan Africa. AIDS. 2001;15:S31-S40. (Pubitemid 32913002)
40. Gray RH, Kiwanuka N, Quinn TC. Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. AIDS. 2000;14:2371-2381.
41. Weiss HA, Quigley MA, Hayes RA. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2000;14:2361-2370.