A continuous ultrasound-assisted packed-bed bioreactor for the lipase-catalyzed synthesis of caffeic acid phenethyl ester

Journal of Chemical Technology and Biotechnology

Volumn 86, Issue 10, 2011, Pages 1289-1294

  Chen, Hsiao Ching ^a   Kuo, Chia Hung ^b   Twu, Yawo Kuo ^a   Chen, Jiann Hwa ^b   Chang, Chieh Ming J ^b   Liu, Yung Chuan ^b   Shieh, Chwen Jen ^b  

^a DA YEH UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Lipase; Packed bed reactor; Phenolic acid; Response surface methodology; Ultrasonication

Indexed keywords

BOX-BEHNKEN DESIGN; CAFFEIC ACID PHENETHYL ESTER; CAFFEIC ACIDS; CANDIDA ANTARCTICA; EFFECTS OF TEMPERATURE; ENZYMATIC SYNTHESIS; FOOD PRODUCTION; LIPASE-CATALYZED SYNTHESIS; MILD REACTION CONDITIONS; MOLAR CONVERSION; NOVOZYMES; NUTRACEUTICALS; OPTIMAL CONDITIONS; OPTIMUM CONDITIONS; PACKED BED REACTOR; PACKED-BED BIOREACTORS; PHENOLIC ACID; REACTION TEMPERATURE; RESPONSE SURFACE METHODOLOGY; ULTRA-SONICATION; ULTRASONIC POWER;

BIOCONVERSION; BIOREACTORS; CATALYSIS; ESTERIFICATION; ESTERS; ETHANOL; FLOW RATE; LIPASES; ORGANIC ACIDS; PACKED BEDS; PHENOLS; SURFACE PROPERTIES; TEMPERATURE; ULTRASONICS;

SYNTHESIS (CHEMICAL);

CAFFEIC ACID PHENETHYL ESTER; TRIACYLGLYCEROL LIPASE;

ARTICLE; BIOREACTOR; CANDIDA ANTARCTICA; CATALYSIS; CONTINUOUS PACKED BED BIOREACTOR; ENZYME IMMOBILIZATION; ENZYME SYNTHESIS; FLOW RATE; REACTION ANALYSIS; REACTION TIME; TEMPERATURE;

CANDIDA ANTARCTICA;

EID: 80052968863     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.2661     Document Type: Article

References (18)

1. Graf E, Antioxidant potential of ferulic acid. Free Radical Bio Med 13: 435-448 (1992).
2. Grunberger D, Banerjee R, Eisinger K, Oltz EM, Efros L, Caldwell M, et al, Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44: 230-232 (1988).
3. Liu L, Hudgins WR, Shack S, Yin MQ and Samid D, Cinnamic acid: a natural product with potential use in cancer intervention. Int J Cancer 62: 345-350 (1995).
4. Chen QH, Fu ML, Jin L, Zhang HF, He GQ and Ruan H, Optimization of ultrasonic-assisted extraction (UAE) of betulin from white birch bark using response surface methodology. Ultrason Sonochem 16: 599-604 (2009).
5. Ramachandran KB, Al-Zuhair S, Fong CS and Gak CW, Kinetic study on hydrolysis of oils by lipase with ultrasonic emulsification. Biochem Eng J 32: 19-24 (2006).
6. Yachmenev VG, Blanchard EJ and Lambert AH, Use of ultrasonic energy for intensification of the bio-preparation of greige cotton. Ultrasonics 42: 87-91 (2004).
7. Li C, Yoshimoto M, Ogata H, Tsukuda N, Fukunaga K and Nakao K, Effects of ultrasonic intensity and reactor scale on kinetics of enzymatic saccharification of various waste papers in continuously irradiated stirred tanks. Ultrason Sonochem 12: 373-384 (2005).
8. Liu Y, Jin Q, Shan L, Liu Y, Shen W and Wang X, The effect of ultrasound on lipase-catalyzed hydrolysis of soy oil in solvent-free system. Ultrason Sonochem 15: 402-407 (2008).
9. Stavarache C, Vinatoru M, Nishimura R and Maeda Y, Fatty acids methyl esters from vegetable oil by means of ultrasonic energy. Ultrason Sonochem 12: 367-372 (2005).
10. Nielsen NS, Yang T, Xu X and Jacobsen C, Production and oxidative stability of a human milk fat substitute produced from lard by enzyme technology in a pilot packed-bed reactor. Food Chem 94: 53-60 (2006).
11. Goddard R, Bosley J and Al-Duri B, Esterification of oleic acid and ethanol in plug flow (packed bed) reactor under supercritical conditions investigation of kinetics. J Supercrit Fluid 18: 121-130 (2000).
12. Piao J, Kobayashi T, Adachi S, Nakanishi K and Matsuno R, Continuous synthesis of lauroyl or oleoyl erythritol by a packed-bed reactor with an immobilized lipase. Process Biochem 39: 681-686 (2004).
13. Chang C, Chen JH, Chang CJ, Wu TT and Shieh CJ, Optimization of lipase-catalyzed biodiesel by isopropanolysis in a continuous packed-bed reactor using response surface methodology. New Biotechnol 26: 187-192 (2009).
14. Xiao YM, Wu Q, Cai Y and Lin XF, Ultrasound-accelerated enzymatic synthesis of sugar esters in nonaqueous solvents. Carbohyd Res 340: 2097-2103 (2005).
15. SAS, SAS User's Guide. SAS Institute, Cary, USA (1990).
16. Ott L, An Introduction to Statistical Methods and Data Analysis. PWS-Kent Publishing, Boston, USA (1988).
17. Chen HC, Ju HY, Twu YK, Chen JH, Chang C-M J, Liu YC, et al, Optimized enzymatic synthesis of caffeic acid phenethyl ester by RSM. New Biotechnol 27: 89-93 (2010).
18. Royon D, Daz M, Ellenrieder G and Locatelli S, Enzymatic production of biodiesel from cotton seed oil using t-butanol as a solvent. Bioresource Technol 98: 648-653 (2007).