Lung function and respiratory symptoms in a 1-year randomized smoking cessation trial of varenicline in COPD patients

Respiratory Medicine

Volumn 105, Issue 11, 2011, Pages 1682-1690

  Tashkin, D P ^a   Rennard, S ^b   Taylor Hays, J ^c   Lawrence, D ^d   Marton, J P ^d   Lee, T C ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c MAYO CLINIC   (United States)

^d PFIZER INC   (United States)

Author keywords

Chronic obstructive pulmonary disease; Lung function; Quality of life; Respiratory symptoms; Smoking cessation; Varenicline

Indexed keywords

VARENICLINE;

ABNORMAL DREAMING; ADULT; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL COPD QUESTIONNAIRE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; FEMALE; FLATULENCE; FOLLOW UP; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; INSOMNIA; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SMOKING; SMOKING CESSATION; SPIROMETRY; TOBACCO DEPENDENCE; TREATMENT DURATION; TREATMENT REFUSAL; UPPER RESPIRATORY TRACT INFECTION; VOMITING;

BENZAZEPINES; DOUBLE-BLIND METHOD; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; NICOTINIC AGONISTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; QUALITY OF LIFE; QUESTIONNAIRES; QUINOXALINES; SMOKING CESSATION; SPIROMETRY;

EID: 80052967109     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2011.04.016     Document Type: Article

References (27)

1. C. Fletcher, R. Peto, C. Tinker, and F. Speizer The Natural history of bronchitis and Emphysema 1976 Oxford University Press Oxford, England
2. 1. The Lung Health Study JAMA 272 19 1994 Nov 16 1497 1505
3. P.D. Scanlon, J.E. Connett, L.A. Waller, M.D. Altose, W.C. Bailey, and A.S. Buist Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study Am J Respir Crit Care Med 161 2 Pt 1 2000 Feb 381 390 (Pubitemid 30129442)
4. R.E. Kanner, J.E. Connett, D.E. Williams, and A.S. Buist Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: The Lung Health Study Am J Med 106 4 1999 Apr 410 416 (Pubitemid 29190593)
5. D. Tashkin, S. Rennard, J. Hays, W. Ma, D. Lawrence, and T. Lee Effects of varenicline on smoking cessation in mild-to-moderate COPD: a randomized controlled trial Chest 2010 Sep 23 [Epub ahead of print]
6. World Medical Association Declaration of Helsinki - Ethical Principles for Medical research involving Human Subjects cited 10 September 2010 Available from http://www.wma.net/en/30publications/10policies/b3/index.html
7. International Conference on Harmonisation The ICH process for harmonisation of guidelines cited 10 September 2010 Available from http://www.ich.org/cache/compo/276-254-1.html
8. M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, and A. Coates Standardisation of spirometry Eur Respir J 26 2 2005 Aug 319 338 (Pubitemid 41079078)
9. P.L. Enright, L.R. Johnson, J.E. Connett, H. Voelker, and A.S. Buist Spirometry in the lung health study. 1. Methods and quality control Am Rev Respir Dis 143 6 1991 Jun 1215 1223
10. T. van der Molen, B.W. Willemse, S. Schokker, N.H. ten Hacken, D.S. Postma, and E.F. Juniper Development, validity and responsiveness of the Clinical COPD Questionnaire Health Qual Life Outcomes 1 2003 13
11. H. Goldstein, and M. Healy The graphical presentation of a collection of means J Royal Stat Soc Ser A (Statistics Society) 158 1 1995 175 177
12. D. Gonzales, S.I. Rennard, M. Nides, C. Oncken, S. Azoulay, and C.B. Billing Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial JAMA 296 1 2006 Jul 5 47 55
13. D.E. Jorenby, J.T. Hays, N.A. Rigotti, S. Azoulay, E.J. Watsky, and K.E. Williams Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial JAMA 296 1 2006 Jul 5 56 63
14. P. Tønnesen, K. Mikkelsen, and L. Bremann Nurse-conducted smoking cessation in patients with COPD using nicotine sublingual tablets and behavioral support Chest 130 2 2006 August 334 342 (Pubitemid 44266998)
15. B.W. Willemse, D.S. Postma, W. Timens, and N.H. ten Hacken The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation Eur Respir J 23 3 2004 Mar 464 476 (Pubitemid 38344387)
16. A.A. Reda, D. Kotz, J.W. Kocks, G. Wesseling, and C.P. van Schayck Reliability and validity of the clinical COPD questionnaire and chronic respiratory questionnaire Respir Med 104 11 2010 Jun 8 1675 1682
17. Centers for Disease Control and Prevention The health benefits of smoking cessation Rockville, MD: US Dept of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Health Promotion and Education, Office on Smoking and Health. Washington, DC 1990 Report No.: DHHS Publication No. (CDC) 90-8416
18. J.B. Mullen, J.L. Wright, B.R. Wiggs, P.D. Paré, and J.C. Hogg Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: relationship to lung function Thorax 42 11 1987 Nov 843 848 (Pubitemid 17160881)
19. A. Pesci, G.A. Rossi, G. Bertorelli, A. Aufiero, P. Zanon, and D. Olivieri Mast cells in the airway lumen and bronchial mucosa of patients with chronic bronchitis Am J Respir Crit Care Med 149 5 1994 May 1311 1316 (Pubitemid 24147075)
20. W.I. de Boer, J.K. Sont, A. van Schadewijk, J. Stolk, J.H. van Krieken, and P.S. Hiemstra Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD J Pathol 190 5 2000 Apr 619 626 (Pubitemid 30164493)
21. G. Turato, A. Di Stefano, P. Maestrelli, C.E. Mapp, M.P. Ruggieri, and A. Roggeri Effect of smoking cessation on airway inflammation in chronic bronchitis Am J Respir Crit Care Med 152 4 Pt 1 1995 Oct 1262 1267
22. J.C. Hogg, F. Chu, S. Utokaparch, R. Woods, W.M. Elliott, and L. Buzatu The nature of small-airway obstruction in chronic obstructive pulmonary disease N Engl J Med 350 26 2004 Jun 24 2645 2653 (Pubitemid 38787999)
23. J. Sunyer, A. Muñoz, Y. Peng, J. Margolick, J.S. Chmiel, and J. Oishi Longitudinal relation between smoking and white blood cells Am J Epidemiol 144 8 1996 Oct 15 734 741 (Pubitemid 26349410)
24. E.J. Jensen, B. Pedersen, R. Frederiksen, and R. Dahl Prospective study on the effect of smoking and nicotine substitution on leucocyte blood counts and relation between blood leucocytes and lung function Thorax 53 9 1998 Sep 784 789 (Pubitemid 28408720)
25. C.M. Sköld, J. Hed, and A. Eklund Smoking cessation rapidly reduces cell recovery in bronchoalveolar lavage fluid, while alveolar macrophage fluorescence remains high Chest 101 4 1992 Apr 989 995
26. D.A. Scott, J.A. Stapleton, R.F. Wilson, G. Sutherland, R.M. Palmer, and P.Y. Coward Dramatic decline in circulating intercellular adhesion molecule-1 concentration on quitting tobacco smoking Blood Cells Mol Dis 26 3 2000 Jun 255 258
27. S.I. Rennard, D. Daughton, J. Fujita, M.B. Oehlerking, J.R. Dobson, and M.G. Stahl Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers Eur Respir J 3 7 1990 Jul 752 759