Modulation of nitric oxide expression with methylene blue does not improve outcome after hypovolemic cardiac arrest

Resuscitation

Volumn 82, Issue 10, 2011, Pages 1344-1349

  Semenas, Egidijus ^a   Nozari, Ala ^b   Thiblin, Ingemar ^c   Rubertsson, Sten ^a   Wiklund, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Forensic Medicine   (Sweden)

Author keywords

Cardiopulmonary resuscitation; Haemorrhage; Methylene blue; Sex

Indexed keywords

DEXTRAN; ELECTROLYTE; ESTRADIOL; GLUCOSE; LACTIC ACID; METHYLENE BLUE; METYLTIONINKLORID; NITRIC OXIDE; SODIUM CHLORIDE; TESTOSTERONE; TROPONIN I; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; DEFIBRILLATION; FEMALE; FLUID RESUSCITATION; HEART ARREST; HEART MUSCLE INJURY; HEART RATE; HEMODYNAMIC PARAMETERS; HISTOPATHOLOGY; HYPOVOLEMIA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PIGLET; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESUSCITATION; SEX DIFFERENCE; SURVIVAL TIME; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME;

ANIMALS; CARDIOPULMONARY RESUSCITATION; FEMALE; HEART ARREST; HYPOVOLEMIA; MALE; METHYLENE BLUE; NITRIC OXIDE; PROGNOSIS; SEX FACTORS; SWINE;

EID: 80052965730     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2011.04.027     Document Type: Article

References (22)

1. Rhee P.M., Acosta J., Bridgeman A., Wang D., Jordan M., Rich N. Survival after emergency department thoracotomy: review of published data from the past 25 years. J Am Coll Surg 2000, 190:288-298.
2. Calkins C.M., Bensard D.D., Partrick D.A., Karrer F.M. A critical analysis of outcome for children sustaining cardiac arrest after blunt trauma. J Pediatr Surg 2002, 37:180-184.
3. Zuercher M., Ummenhofer W. Cardiac arrest during anesthesia. Curr Opin Crit Care 2008, 14:269-274.
4. Semenas E., Nozari A., Sharma H.S., Basu S., Rubertsson S., Wiklund L. Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs. Acta Anaesthesiol Scand 2010, 54:343-353.
5. Semenas E., Nozari A., Wiklund L. Sex differences in cardiac injury after severe haemorrhage and ventricular fibrillation in pigs. Resuscitation 2010, 81:1718-1722.
6. Xu X.P., Pollock J.S., Tanner M.A., Myers P.R. Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells. Cardiovasc Res 1995, 30:841-847.
7. Krismer A.C., Lindner K.H., Wenzel V., Rainer B., Mueller G., Lingnau W. Inhibition of nitric oxide improves coronary perfusion pressure and return of spontaneous circulation in a porcine cardiopulmonary resuscitation model. Crit Care Med 2001, 29:482-486.
8. Miclescu A., Basu S., Wiklund L. Methylene blue added to a hypertonic-hyperoncotic solution increases short-term survival in experimental cardiac arrest. Crit Care Med 2006, 34:2806-2813.
9. Miclescu A., Basu S., Wiklund L. Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitation. Resuscitation 2007, 75:88-97.
10. Wolin M.S., Cherry P.D., Rodenburg J.M., Messina E.J., Kaley G. Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. J Pharmacol Exp Ther 1990, 254:872-876.
11. Wiklund L., Basu S., Miclescu A., Wiklund P., Ronquist G., Sharma H.S. Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue. Ann NY Acad Sci 2007, 1122:231-244.
12. Gillman P.K. Methylene blue is a potent monoamine oxidase inhibitor. Can J Anaesth 2008, 55:311-312. author reply 312.
13. Schror K., Grodzinska L., Darius H. Stimulation of coronary vascular prostacyclin and inhibition of human platelet thromboxane A2 after low-dose nitroglycerin. Thromb Res 1981, 23:59-67.
14. Kelner M.J., Bagnell R., Hale B., Alexander N.M. Potential of methylene blue to block oxygen radical generation in reperfusion injury. Basic Life Sci 1988, 49:895-898.
15. Hannon J.P., Bossone C.A., Wade C.E. Normal physiological values for conscious pigs used in biomedical research. Lab Anim Sci 1990, 40:293-298.
16. Burrows G.E. Methylene blue: effects and disposition in sheep. J Vet Pharmacol Ther 1984, 7:225-231.
17. Bancroft J., Cook H., Turner D. Manual of histological techniques and their diagnostic application 1994, Churchill Livingstone. 2nd edition.
18. Ferreira M.A., Owen H.E., Howie A.J. High prevalence of acute myocardial damage in a hospital necropsy series, shown by C9 immunohistology. J Clin Pathol 1998, 51:548-551.
19. Clifton J., Leikin J.B. Methylene blue. Am J Ther 2003, 10:289-291.
20. Hoshida S., Yamashita N., Igarashi J., et al. Nitric oxide synthase protects the heart against ischemia-reperfusion injury in rabbits. J Pharmacol Exp Ther 1995, 274:413-418.
21. Mohan P., Brutsaert D.L., Paulus W.J., Sys S.U. Myocardial contractile response to nitric oxide and cGMP. Circulation 1996, 93:1223-1229.
22. Murphy E., Steenbergen C. Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury. Cardiovasc Res 2007, 75:478-486.