Synthesis and antiviral evaluation of α-l-2′- deoxythreofuranosyl nucleosides

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3704-3713

  Toti, Kiran S ^a   Derudas, Marco ^b   McGuigan, Christopher ^b   Balzarini, Jan ^c   Van Calenbergh, Serge ^a  

^a GHENT UNIVERSITY   (Belgium)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antivirals; Enzyme inhibitors; Nucleoside analogs; Prodrugs

Indexed keywords

1 (TETRAHYDRO 4 HYDROXYFURAN 2 YL) 5 METHYLPYRIMIDINE 2,4 (1H,3H)DIONE; 1 (TETRAHYDRO 4 HYDROXYFURAN 2 YL)PYRIMIDINE 2,4(1H,3H)DIONE; 1 [4 (4 METHOXYBENZYLOXY)TETRAHYDRO 3 HYDROXYFURAN 2 YL] 5 METHYLPYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (4 METHOXYBENZYLOXY)TETRAHYDRO 3 HYDROXYFURAN 2 YL]PYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (4 METHOXYBENZYLOXY)TETRAHYDROFURAN 2 YL] 5 METHYLPYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (4 METHOXYBENZYLOXY)TETRAHYDROFURAN 2 YL]PYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (BENZYLOXY)TETRAHYDRO 3 HYDROXYFURAN 2 YL] 5 METHYLPYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (BENZYLOXY)TETRAHYDRO 3 HYDROXYFURAN 2 YL]PYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (BENZYLOXY)TETRAHYDROFURAN 2 YL] 5 METHYLPYRIMIDINE 2,4 (1H,3H)DIONE; 1 [4 (BENZYLOXY)TETRAHYDROFURAN 2 YL]PYRIMIDINE 2,4 (1H,3H)DIONE; 2 (6 AMINO 9H PURIN 9 YL) 4 (BENZYLOXY)TETRAHYDROFURAN 3 OL; 2 [6 (BENZAMIDO) 9H PURIN 9 YL] 4 (BENZYLOXY)TETRAHYDROFURAN 3 YL ACETATE; 4 (4 METHOXYBENZYLOXY)TETRAHYDRO 2 [3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL]FURAN 3 YL ACETATE; 4 (4 METHOXYBENZYLOXY)TETRAHYDRO 2 [3,4 DIHYDRO 5 METHYL 2,4 DIOXOPYRIMIDIN 1 (2H)YL]FURAN 3 YL ACETATE; 4 (4 METHOXYBENZYLOXY)TETRAHYDRO 2,3 FURANYLDIACETATE; 4 (BENZYLOXY)TETRAHYDRO 2 [3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL]FURAN 3 YL ACETATE; 4 (BENZYLOXY)TETRAHYDRO 2 [3,4 DIHYDRO 5 METHYL 2,4 DIOXOPYRIMIDIN 1 (2H)YL]FURAN 3 YL ACETATE; 4 (BENZYLOXY)TETRAHYDRO 2 [4 (ACETYLAMINO) 2 OXOPYRIMIDIN 1 (2H)YL]FURAN 3 YL ACETATE; 4 AMINO 1 [4 (BENZYLOXY)TETRAHYDRO 3 HYDROXYFURAN 2 YL]PYRIMIDIN 2 (1H)ONE; 6 (4 METHOXYBENZYLOXY)TETRAHYDRO 2,2 DIMETHYLFURO[2,3 D][1,3]DIOXOLE; 6 (BENZYLOXY)TETRAHYDRO 2,2 DIMETHYLFURO[2,3 D][1,3]DIOXOLE; 9 [4 (BENZYLOXY)TETRAHYDROFURAN 2 YL] 9H PURIN 6 AMINE; ALPHA 20 DEOXYTHREOFURANOSYL NUCLEOSIDE DERIVATIVE; ANTIVIRUS AGENT; N [1 [4 (BENZYLOXY)TETRAHYDRO 3 HYDROXYFURAN2 YL] 1,2 DIHYDRO 2 OXOPYRIMIDIN 4 YL]ACETAMIDE; N [1 [4 (BENZYLOXY)TETRAHYDROFURAN 2 YL] 1,2 DIHYDRO 2 OXOPYRIMIDIN 4 YL]ACETAMIDE; NUCLEOSIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BARTON MCCOMBIE DEOXYGENATION; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOTOXICITY; DEOXYGENATION; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; VARICELLA ZOSTER VIRUS; VORBRUGGEN COUPLING;

ANTIVIRAL AGENTS; CATHEPSIN A; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; NUCLEOSIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

EID: 80052949867     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.036     Document Type: Article

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