HPLC-UV method development for fentanyl determination in rat plasma and its application to elucidate pharmacokinetic behavior after i.p. administration to rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 27, 2011, Pages 2941-2944

  Almousa, Ahmed A ^a   Ikeda, Rie ^a   Wada, Mitsuhiro ^a   Kuroda, Naotoka ^a   Hanajiri, Ruri Kikura ^b   Nakashima, Kenichiro ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Deproteinization; Fentanyl; High performance liquid chromatography; Pharmacokinetics; Rat plasma; UV detection

Indexed keywords

ACETATE BUFFERS; CALIBRATION CURVES; CHROMATOGRAPHIC SEPARATIONS; DEPROTEINIZATION; DETECTION WAVELENGTHS; FENTANYLS; HPLC-UV; INTERNAL STANDARDS; INTRAPERITONEAL ADMINISTRATION; LIMIT OF DETECTION; LIQUID EXTRACTION; METHOD DEVELOPMENT; MOBILE PHASE; MOMENT ANALYSIS; ORGANIC LAYERS; PHARMACOKINETIC PARAMETERS; PLASMA SAMPLES; PRE-TREATMENT; RAT PLASMA; RECONSTITUTED SAMPLE; SAMPLE ANALYSIS; SAMPLE PRETREATMENT; SOLID-PHASE EXTRACTION; TERT-BUTYL METHYL ETHERS; UV DETECTION; WISTAR RAT;

ACETONITRILE; ANESTHETICS; BODY FLUIDS; CENTRIFUGATION; CHROMATOGRAPHY; EFFLUENT TREATMENT; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; PHARMACOKINETICS; PLASMAS; SOLVENT EXTRACTION; VOLATILE FATTY ACIDS; WETLANDS;

RATS;

ACETIC ACID; ACETONITRILE; BUFFER; CLONIDINE; FENTANYL; NITROGEN; TERT BUTYL METHYL ETHER;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CALIBRATION; CENTRIFUGATION; CONTROLLED STUDY; DEPROTEINIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; ISOLATION PROCEDURE; LIMIT OF DETECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; SOLID PHASE EXTRACTION; ULTRAVIOLET SPECTROSCOPY; WISTAR RAT;

ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; FENTANYL; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

RATTUS; RATTUS NORVEGICUS;

EID: 80052946712     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.08.029     Document Type: Article

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