Development of superparamagnetic high-magnetization C18-functionalized magnetic silica nanoparticles as sorbents for enrichment and determination of methylprednisolone in rat plasma by high performance liquid chromatography

Analytica Chimica Acta

Volumn 678, Issue 1, 2010, Pages 50-55

  Yu, Panfeng ^a   Wang, Qi ^b   Zhang, Xifeng ^a   Zhang, Xuesong ^a   Shen, Shun ^c   Wang, Yan ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b AIR FORCE GENERAL HOSPITAL   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

C18 functionalized magnetic silica nanoparticles; High performance liquid chromatography; Methylprednisolone; Rat plasma; Sorbents

Indexed keywords

ADSORPTION TIME; COMPLEX PLASMA; DETECTION LIMITS; ENRICHMENT TECHNIQUES; EXTRACTION CONDITIONS; FUNCTIONALIZED; HIGH SURFACE AREA; HYDROPHOBIC INTERACTIONS; LINEAR RANGE; METHOD VALIDATIONS; METHYLPREDNISOLONE; N-HEXANE; NOVEL EXTRACTION; OCTADECYLSILANE; RAT PLASMA; SILICA NANOPARTICLES; SUPERPARAMAGNETICS; SYNTHESIZED SILICA;

ADSORPTION; DESORPTION; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; IRON ORES; LIQUIDS; MAGNETIZATION; NANOPARTICLES; PLASMA (HUMAN); PLASMAS; SILICA; SORBENTS; SUPERPARAMAGNETISM;

NANOMAGNETICS;

MAGNETIC NANOPARTICLE; MAGNETIC SILICA NANOPARTICLE; METHYLPREDNISOLONE; UNCLASSIFIED DRUG;

ACCURACY; ADSORPTION KINETICS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; MALE; MATERIAL COATING; MOLECULAR INTERACTION; MOLECULAR SIZE; NANOANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; RAT; REACTION TIME; SINGLE DRUG DOSE; SURFACE PROPERTY; SYNTHESIS; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERROSOFERRIC OXIDE; MAGNETICS; METHYLPREDNISOLONE; NANOPARTICLES; RATS; SILICON DIOXIDE;

RATTUS;

EID: 77956998193     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2010.08.012     Document Type: Article

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