A new nitrosyl ruthenium complex: Synthesis, chemical characterization, in vitro and in vivo antitumor activities and probable mechanism of action

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3616-3622

  Heinrich, Tassiele A ^a   Von Poelhsitz, Gustavo ^b   Reis, Rosana I ^a   Castellano, Eduardo E ^a   Neves, Ademir ^c   Lanznaster, Maurício ^d   MacHado, Sérgio P ^b   Batista, Alzir A ^e   Costa Neto, Claudio M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^d FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

2 hydroxybenzyl(2 methylpyridyl)amine; Apoptosis; Cytotoxicity; DNA interaction; Melanoma; Ruthenium complex

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 4 [2 (DIFLUOROMETHOXY)PHENYL] 1,4,5,7 TETRAHYDRO 2 METHYL 5 OXOFURO[3,4 B]PYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; CISPLATIN; DNA; NITROSYL RUTHENIUM COMPLEX; OSI 4161; OSI 9961; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCULATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MOUSE; NONHUMAN; POTENTIOMETRY; SPECTROSCOPY; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; RUTHENIUM COMPOUNDS; SPECTRUM ANALYSIS;

EID: 80052941186     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.064     Document Type: Article

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