Synthesis and structure-activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6094-6099

  Jin, Yafei ^a   Gill, Sumandeep K ^a   Kirchhoff, Paul D ^a   Wan, Baojie ^b   Franzblau, Scott G ^b   Garcia, George A ^a   Showalter, H D Hollis ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Escherichia coli; MTB; Rifamycin; RNAP

Indexed keywords

PREGNANE X RECEPTOR; PYRAZOLE DERIVATIVE; RIFAMPICIN DERIVATIVE; RIFAMYCIN S DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; CONCENTRATION RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HYDROGEN BOND; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS;

EID: 80052931783     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.054     Document Type: Article

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