Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4168-4177

  Krstić, Milena ^a   Sovilj, Sofija P ^b   Grgurić Šipka, Sanja ^b   Evans, Ivana Radosavljević ^c   Borozan, Sunčica ^a   Santibanez, Juan Francisco ^d  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c DURHAM UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Antioxidant enzymes; Cytotoxicity; N Alkylphenothiazines; p Cymene; Ruthenium complexes; Single crystal X ray diffraction

Indexed keywords

10 [2 (1 METHYL 2 PIPERIDYL)ETHYL] 2 (METHYLTHIO) PHENOTHIAZINE HYDROCHLORIDE; 10 [3 (4 METHYL 1 PIPERAZINYL)PROPYL] 2 TRIFLUOROMETHYL PHENOTHIAZINE DIHYDROCHLORIDE; 10 [3 (DIMETHYLAMINO)PROPYL] 2 CHLORO PHENOTHIAZINE HYDROCHLORIDE; CATALASE; CHLORPROMAZINE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRITE; PARA CYMENE; PHENOTHIAZINE DERIVATIVE; RUTHENIUM COMPLEX; SUPEROXIDE DISMUTASE; THIORIDAZINE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CELL VIABILITY; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ERYTHROCYTE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO CULTURE; INFRARED SPECTROSCOPY; MULTIPLE MYELOMA; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; TREATMENT OUTCOME; ULTRAVIOLET SPECTROSCOPY; X RAY DIFFRACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FREE RADICAL SCAVENGERS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOTERPENES; PHENOTHIAZINES; RATS; RATS, WISTAR; RUTHENIUM COMPOUNDS; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 80052929773     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.019     Document Type: Article

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