메뉴 건너뛰기




Volumn 52, Issue 3, 2011, Pages 111-115

Utility of thymosin α-1 (Zadaxin™) as a co-adjuvant in influenza vaccines: A review

Author keywords

Elderly; Immunocompromised subjects; Influenza vaccine; Thymosin alfa 1; Zadaxin

Indexed keywords

ALPHA INTERFERON; ALUMINUM POTASSIUM SULFATE; CHEMOKINE; DIPHTHERIA TOXOID; GAMMA INTERFERON; HEPATITIS B VACCINE; I KAPPA B KINASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INDOLEAMINE 2,3 DIOXYGENASE; INFLUENZA VACCINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MIFAMURTIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; THYMOSIN ALPHA1; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; VIROSOME;

EID: 80052925467     PISSN: 11212233     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (57)
  • 1
    • 0028061567 scopus 로고
    • Prevention of respiratory infections in adults: Influenza and pneumococcal vaccines
    • DOI 10.1001/archinte.154.22.2545
    • Fiebach N, Beckett W. Prevention of respiratory infections in adults: influenza and pneumoccocal vaccines. Arch Intern Med 1994;154:2545-57. (Pubitemid 24362405)
    • (1994) Archives of Internal Medicine , vol.154 , Issue.22 , pp. 2545-2557
    • Fiebach, N.1    Beckett, W.2
  • 2
    • 79957577944 scopus 로고    scopus 로고
    • Accessed on October 9, 2010
    • Center for Disease Control and Prevention. Seasonal Influenza. http://www.cdc.gov/flu/about/qa/disease.htm [Accessed on October 9, 2010].
    • Seasonal Influenza
  • 3
    • 0029736924 scopus 로고    scopus 로고
    • Health impact of influenza in the United States
    • Sullivan KM. Health impact of influenza in United States. Pharmacoeconomics 1996;9:26-33. (Pubitemid 26308765)
    • (1996) PharmacoEconomics , vol.9 , Issue.SUPPL. 3 , pp. 26-33
    • Sullivan, K.M.1
  • 4
    • 44049083358 scopus 로고    scopus 로고
    • Lessons from 40 years' surveillance of influenza in England and Wales
    • DOI 10.1017/S0950268807009910, PII S0950268807009910
    • Fleming DM, Elliot AJ. Lessons from 40 years' surveillance of influenza in England and Wales. Epidemiol Infect 2008;136:866-75. (Pubitemid 351712521)
    • (2008) Epidemiology and Infection , vol.136 , Issue.7 , pp. 866-875
    • Fleming, D.M.1    Elliot, A.J.2
  • 5
    • 0033806289 scopus 로고    scopus 로고
    • Mortality caused by sepsis in patients with end-stage renal disease compared with the general population
    • Sarnak MJ, Jaber BL. Mortality caused by sepsis in patients with end-stage renal disease compared with the general population. Kidney Int 2000;58:1758-64.
    • (2000) Kidney Int , vol.58 , pp. 1758-1764
    • Sarnak, M.J.1    Jaber, B.L.2
  • 7
    • 0020655521 scopus 로고
    • Impaired humoral and cell-mediated immune responses in dialyzed patients after influenza vaccination
    • Cappel R, Van Beers D, Liesnard C, et al. Impaired humoral and cell-mediated immune response in dialyzed patients after influenza vaccination. Nephron 1983;33:21-5. (Pubitemid 13173057)
    • (1983) Nephron , vol.33 , Issue.1 , pp. 21-25
    • Cappel, R.1    Van Beers, D.2    Liesnard, C.3    Dratwa, M.4
  • 9
    • 48949089658 scopus 로고    scopus 로고
    • Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008
    • Fiore AE, Shay DK, Broder K, et al. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008. MMWR Recomm Rep 2008;57:1-60.
    • (2008) MMWR Recomm Rep , vol.57 , pp. 1-60
    • Fiore, A.E.1    Shay, D.K.2    Broder, K.3
  • 10
    • 84945451510 scopus 로고    scopus 로고
    • WHO: Global Influenza Programme. http://www.who.int/csr/disease/ influenza/mission/en/index.html
    • Global Influenza Programme
  • 13
    • 79953238948 scopus 로고    scopus 로고
    • Influenza vaccine uptake among community-dwelling Italian ederly: Results from a large cross-sectional study
    • Chiatti C, Barbadoro P, Lamura G, et al. Influenza vaccine uptake among community-dwelling Italian ederly: results from a large cross-sectional study. BMC Public Health 2011;11:207.
    • (2011) BMC Public Health , vol.11 , pp. 207
    • Chiatti, C.1    Barbadoro, P.2    Lamura, G.3
  • 14
    • 0035925666 scopus 로고    scopus 로고
    • The adjuvanted influenza vaccines with novel adjuvants: Experience with the MF59-adjuvanted vaccine
    • DOI 10.1016/S0264-410X(00)00499-0, PII S0264410X00004990
    • Podda A. The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine. Vaccine 2001;19:2673-80. (Pubitemid 32234288)
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2673-2680
    • Podda, A.1
  • 15
    • 80052945070 scopus 로고    scopus 로고
    • Today's Influenza Vaccines - Why an adjuvant is needed and how it works
    • Panatto D, Lai P, Gasparini R. Today's Influenza Vaccines - Why an adjuvant is needed and how it works. Eur Infect Dis 2010;4:36-40.
    • (2010) Eur Infect Dis , vol.4 , pp. 36-40
    • Panatto, D.1    Lai, P.2    Gasparini, R.3
  • 16
    • 0013945220 scopus 로고
    • Preparation, assay and partial purification of a thymic lymphocytopoietic factor [Thymosin]
    • Goldstein AL, Slater FD, White A. Preparation, assay and partial purification of a thymic lymphocytopoietic factor [Thymosin]. Proc Natl Acad Sci U S A 1966;56:1010-7.
    • (1966) Proc Natl Acad Sci U S A , vol.56 , pp. 1010-1017
    • Goldstein, A.L.1    Slater, F.D.2    White, A.3
  • 18
    • 1842734249 scopus 로고    scopus 로고
    • Thymosins: Chemistry and biological properties in health and disease
    • DOI 10.1517/14712598.4.4.559
    • Goldstein AL, Badamchian M. Thymosins: chemistry and biological properties in health and diseases. Expert Opin Biol Ther 2004;4:559-73. (Pubitemid 38480555)
    • (2004) Expert Opinion on Biological Therapy , vol.4 , Issue.4 , pp. 559-573
    • Goldstein, A.L.1    Badamchian, M.2
  • 19
    • 80052922975 scopus 로고
    • Role of the Thymosine as immunomodulating agents and maturation factors
    • Moore MA, ed. New York: Raven
    • Low T, Goldstein A. Role of the Thymosine as immunomodulating agents and maturation factors. In: Moore MA, ed. Maturation Factors and Cancer. New York: Raven 1982, pp. 129-52.
    • (1982) Maturation Factors and Cancer , pp. 129-152
    • Low, T.1    Goldstein, A.2
  • 20
    • 0005736787 scopus 로고
    • Thymosin, peptidemoieties, and related agents
    • Fenichel RL, Chirigus MA, eds. New York: Dekker
    • Low T, Goldstein A. Thymosin, peptidemoieties, and related agents. In: Fenichel RL, Chirigus MA, eds. Immune Modulation Agents and Their Mechanisms. New York: Dekker 1984, pp. 135-62.
    • (1984) Immune Modulation Agents and Their Mechanisms , pp. 135-162
    • Low, T.1    Goldstein, A.2
  • 21
    • 0018587801 scopus 로고
    • T-lymphocyte maturation: Cell surface markers and immune function induced by lymphocyte cell-free products and thymosin polypeptides
    • Ahmed A, Wong DM, Thurman GB, et al. T-lymphocyte maturation: cell surface markers and immune function induced by lymphocyte cell-free products and thymosin polypeptides. Ann N Y Acad Sci 1979;332:81-94.
    • (1979) Ann N Y Acad Sci , vol.332 , pp. 81-94
    • Ahmed, A.1    Wong, D.M.2    Thurman, G.B.3
  • 22
    • 52949097257 scopus 로고    scopus 로고
    • Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells
    • Peng Y, Chen Z, Yu W, et al. Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells. Cell Biol Int 2008;32:1265-71.
    • (2008) Cell Biol Int , vol.32 , pp. 1265-1271
    • Peng, Y.1    Chen, Z.2    Yu, W.3
  • 23
    • 34249713219 scopus 로고    scopus 로고
    • + monocytes
    • DOI 10.1016/j.imlet.2007.04.007, PII S0165247807000776
    • Yao Q, Doan LX, Zhang R, et al. Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes. Immunol Lett 2007;110:110-20. (Pubitemid 46839137)
    • (2007) Immunology Letters , vol.110 , Issue.2 , pp. 110-120
    • Yao, Q.1    Doan, L.X.2    Zhang, R.3    Bharadwaj, U.4    Li, M.5    Chen, C.6
  • 24
    • 28944433308 scopus 로고    scopus 로고
    • Thymalfasin for the treatment of chronic hepatitis C infection
    • DOI 10.1586/14787210.3.6.885
    • Rustgi VK. Thymalfasin for the treatment of chronic hepatitis C infection. Expert Rev Anti Infect Ther 2005;3:885-92. (Pubitemid 41782589)
    • (2005) Expert Review of Anti-Infective Therapy , vol.3 , Issue.6 , pp. 885-892
    • Rustgi, V.K.1
  • 25
    • 0025019511 scopus 로고
    • Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes
    • DOI 10.1016/0192-0561(90)90064-T
    • Leichtling KD, Serrate SA, Sztein MB. Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes. Int J Immunopharmacol 1990;12:19-29. (Pubitemid 20034207)
    • (1990) International Journal of Immunopharmacology , vol.12 , Issue.1 , pp. 19-29
    • Leichtling, K.D.1    Serrate, S.A.2    Sztein, M.B.3
  • 26
    • 10744223894 scopus 로고    scopus 로고
    • Thymosin-alpha 1 plus interferon-alpha for naive patients with chronic hepatitis
    • Andreone P, Gramenzi A, Cursaro C, et al. Thymosin-alpha 1 plus interferon-alpha for naive patients with chronic hepatitis. J Viral Hepat 2004;11:69-73.
    • (2004) J Viral Hepat , vol.11 , pp. 69-73
    • Andreone, P.1    Gramenzi, A.2    Cursaro, C.3
  • 30
    • 76349083145 scopus 로고    scopus 로고
    • Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma
    • Sungarian A, Cielo D, Sampath P, et al. Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma. J Oncol 2009;2009:302084.
    • (2009) J Oncol , vol.2009 , pp. 302084
    • Sungarian, A.1    Cielo, D.2    Sampath, P.3
  • 31
    • 22144466919 scopus 로고    scopus 로고
    • Activation of IKK by thymosin α1 requires the TRAF6 signalling pastway
    • Zhang P, Chan J, Dragoi AM, et al. Activation of IKK by thymosin α1 requires the TRAF6 signalling pastway. EMBO Rep 2005;6:537.
    • (2005) EMBO Rep , vol.6 , pp. 537
    • Zhang, P.1    Chan, J.2    Dragoi, A.M.3
  • 34
    • 67349228394 scopus 로고    scopus 로고
    • Proliferative and anti-proliferatie effects of thymosin alpha1 on cells are associated with manipulation of cellular ROS levels
    • Qin Y, Chen FD, Zhou L, et al. Proliferative and anti-proliferatie effects of thymosin alpha1 on cells are associated with manipulation of cellular ROS levels. Chem Biol Interact 2009;180:383-8.
    • (2009) Chem Biol Interact , vol.180 , pp. 383-388
    • Qin, Y.1    Chen, F.D.2    Zhou, L.3
  • 36
    • 0032889359 scopus 로고    scopus 로고
    • Immune response to influenza vaccination in a large healthy elderly population
    • DOI 10.1016/S0264-410X(98)00117-0, PII S0264410X98001170
    • Bernstein E, Kaye D, Abrutyn, et al. Immune response to influenza vaccination in a large-scale healthy elderly population. Vaccine 1999;17:82-94. (Pubitemid 28470736)
    • (1999) Vaccine , vol.17 , Issue.1 , pp. 82-94
    • Bernstein, E.1    Kaye, D.2    Abrutyn, E.3    Gross, P.4    Dorfman, M.5    Murasko, D.M.6
  • 37
    • 20344371900 scopus 로고    scopus 로고
    • Insights into thymic aging and regeneration
    • DOI 10.1111/j.0105-2896.2005.00275.x
    • Taub DD, Longo DL. Insights into thymic aging and regeneration. Immunol Rev 2005;205:72-93. (Pubitemid 40780178)
    • (2005) Immunological Reviews , vol.205 , pp. 72-93
    • Taub, D.D.1    Longo, D.L.2
  • 38
    • 25844467829 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines in elderly people: A systematic review
    • DOI 10.1016/S0140-6736(05)67339-4, PII S0140673605673394
    • Jefferson T, Rivetti D, Rivetti A, et al. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet 2005;366:1165-74. (Pubitemid 41393594)
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1165-1174
    • Jefferson, T.1    Rivetti, D.2    Rivetti, A.3    Rudin, M.4    Di, P.C.5    Demicheli, V.6
  • 39
    • 1842515730 scopus 로고    scopus 로고
    • Influenza surveillance in the Italian region of Liguria in the winter of 1999-2000 by general practitioners and paediatricians: Socio-economic implications
    • Gasparini R, Lucioni C, Lai P, et al. Influenza surveillance in the Italian region of Liguria in the winter of 1999-2000 by general practitioners and paediatricians: socio-economic implications. J Prev Med Hyg 2001;42:83-6.
    • (2001) J Prev Med Hyg , vol.42 , pp. 83-86
    • Gasparini, R.1    Lucioni, C.2    Lai, P.3
  • 41
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccination in the elderly: A quantitative review
    • Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2005;24:1159-69.
    • (2005) Vaccine , vol.24 , pp. 1159-1169
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 45
    • 84887212536 scopus 로고    scopus 로고
    • MF59-adjuvated H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults
    • Banzhoff A, Gasparini R, Laghi-Pasini F, et al. MF59-adjuvated H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. PLoS One 2009;4:e4384.
    • (2009) PLoS One , vol.4
    • Banzhoff, A.1    Gasparini, R.2    Laghi-Pasini, F.3
  • 46
    • 76349101141 scopus 로고    scopus 로고
    • Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvated H1N1v vaccine (Focetria) in adult and elderly subjects
    • Gasparini R, Schioppa F, Lattanzi M, et al. Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvated H1N1v vaccine (Focetria) in adult and elderly subjects. Int J Clin Pract 2010;64:432-8.
    • (2010) Int J Clin Pract , vol.64 , pp. 432-438
    • Gasparini, R.1    Schioppa, F.2    Lattanzi, M.3
  • 47
    • 0021971822 scopus 로고
    • Effect of thymosin alpha one on specific antibody response and susceptibility to infection in young and aged mice
    • DOI 10.1016/0192-0561(85)90065-7
    • Ershler WB, Hebert JC, Blow AJ, et al. Effect of thymosin alpha one on specific antibody response and susceptibility to infection in young and aged mice. Int J Immunopharmacol 1985;7:465-71. (Pubitemid 15233466)
    • (1985) International Journal of Immunopharmacology , vol.7 , Issue.4 , pp. 465-471
    • Ershler, W.B.1    Hebert, J.C.2    Blow, A.J.3
  • 49
    • 0021709175 scopus 로고
    • Influenza and aging: Age-related changes and the effects of thymosin on the antibody response to influenza vaccine
    • DOI 10.1007/BF00916574
    • Ershler W, Moore A, Socinski M. Influenza and aging: age-related changes and the effects of thymosin on the antibody response to influenza vaccine. J Clin Immunol 1984;4:445-54. (Pubitemid 15217438)
    • (1984) Journal of Clinical Immunology , vol.4 , Issue.6 , pp. 445-454
    • Ershler, T.R.1    Moore, A.L.2    Socinski, M.A.3
  • 50
    • 35349006486 scopus 로고    scopus 로고
    • Thymosin alpha 1 as an adjunct to influenza vaccination in the elderly: Rationale and trial summaries
    • DOI 10.1196/annals.1415.050
    • Ershler WB, Gravenstein S, Geloo ZS. Thymosin alpha 1 as an adjunct to influenza vaccination in the elderly: rationale and trial summaries. Ann N Y Acad Sci 2007;1112:375-84. (Pubitemid 47598685)
    • (2007) Annals of the New York Academy of Sciences , vol.1112 , pp. 375-384
    • Ershler, W.B.1    Gravenstein, S.2    Geloo, Z.S.3
  • 51
    • 33544465279 scopus 로고
    • Anti-influenza antibody response: Augmentation in elderly "non-responders"by thymosin alpha 1
    • Gravenstein S, Ershler WB, Drumaskin S, et al. Anti-influenza antibody response: augmentation in elderly "non-responders"by thymosin alpha 1. Gerontologist 1986;26:150a.
    • (1986) Gerontologist , vol.26
    • Gravenstein, S.1    Ershler, W.B.2    Drumaskin, S.3
  • 53
    • 1842667832 scopus 로고
    • Augmentation of influenza antibody levels and reduction in attack rates in elderly subjects by thymosin alpha 1
    • McConnell L, Gravenstein S, Roecker E, et al. Augmentation of influenza antibody levels and reduction in attack rates in elderly subjects by thymosin alpha 1. Gerontologist 1989;29:188a.
    • (1989) Gerontologist , vol.29
    • McConnell, L.1    Gravenstein, S.2    Roecker, E.3
  • 55
    • 26344477682 scopus 로고
    • Age-dependent enhancement of influenza vaccine responses by thymosin in chronic hemodialysis patients
    • Goldstein AL, ed. New York: Plenum Press
    • Shen SY, Corteza QB, Josselson J, et al. Age-dependent enhancement of influenza vaccine responses by thymosin in chronic hemodialysis patients. In: Goldstein AL, ed. Biomedical Advances in Ageing. New York: Plenum Press 1990, pp. 523-30.
    • (1990) Biomedical Advances in Ageing , pp. 523-530
    • Shen, S.Y.1    Corteza, Q.B.2    Josselson, J.3
  • 56
    • 0011827999 scopus 로고
    • Effect of thymosin alpha 1 on heptavax-B vaccination among hemodialysis patients
    • Steve Y, Shen S, Josselson J, et al. Effect of thymosin alpha 1 on heptavax-B vaccination among hemodialysis patients. Kidney Int 1987;31:217.
    • (1987) Kidney Int , vol.31 , pp. 217
    • Steve, Y.1    Shen, S.2    Josselson, J.3
  • 57
    • 77951876822 scopus 로고
    • Effects of thymosin alpha 1 on peripheral T-cell and Heptavax-B vaccination in previously non-responsive hemodialysis patients
    • Shen SY, Josselson J, McRoy C, et al. Effects of thymosin alpha 1 on peripheral T-cell and Heptavax-B vaccination in previously non-responsive hemodialysis patients. Hepatology 1987;7:1120.
    • (1987) Hepatology , vol.7 , pp. 1120
    • Shen, S.Y.1    Josselson, J.2    McRoy, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.