Thymosin alpha 1 as an adjunct to influenza vaccination in the elderly: Rationale and trial summaries

Annals of the New York Academy of Sciences

Volumn 1112, Issue , 2007, Pages 375-384

  Ershler, William B ^a,b,e   Gravenstein, Stefan ^b,c   Geloo, Zeba S ^b,d  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Institute for Advanced Studies in Aging and Geriatric Medicine   (United States)

^c BROWN UNIVERSITY   (United States)

^d Hebrew Home of Greater Washington   (United States)

^e HARBOR HOSPITAL   (United States)

Author keywords

Aging; Influenza; Thymosin alpha 1; Vaccine

Indexed keywords

INFLUENZA VACCINE; PLACEBO; THYMOSIN ALPHA1;

ADJUVANT THERAPY; AGING; CLINICAL TRIAL; CONFERENCE PAPER; EXPERIMENTAL MODEL; HUMAN; IMMUNIZATION; INFECTION SENSITIVITY; INFLUENZA; INFLUENZA VACCINATION; MEDICAL LITERATURE; MORBIDITY; MORTALITY; NONHUMAN; PREVENTIVE MEDICINE; PROTECTION; SENESCENCE; TREATMENT RESPONSE;

ANIMALIA;

EID: 35349006486     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1415.050     Document Type: Conference Paper

References (51)

1. GLOBERSON, A. & R.B. EFFROS. 2000. Ageing of lymphocytes and lymphocytes in the aged. Immunol. Today 21: 515-521.
2. VALLEJO, A.N. 2006. Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged. Immunol. Res. 36: 221-228.
3. EFFROS, R.B., Z. CAI & P.J. LINTON. 2003. CD8 T cells and aging. Crit. Rev. Immunol. 23: 45-64.
4. GRUBECK-LOEBENSTEIN B. & G. WICK. 2002. The aging of the immune system. Adv. Immunol. 80: 243-284.
5. TAUB, D.D. & D.L. LONGO. 2005. Insights into thymic aging and regeneration. Immunol. Rev. 205: 72-93.
6. CHEUNG, T.K. & L.L. POON. 2007. Biology of influenza a virus. Ann. N. Y. Acad. Sci. 1102: 1-25.
7. DESSELBERGER, U., V.R. RACANIELLO, J.J. ZAZRA & P. PALESE. 1980. The 3′ and 5′-terminal sequences of influenza A, B and C virus RNA segments are highly conserved and show partial inverted complementarity. Gene 8: 315-328.
8. FOUCHIER, R.A., V. MUNSTER, A. WALLENSTEN, et al. 2005. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J. Virol. 79: 2814-2822.
9. LAVER, W.G., P.M. COLMAN, R.G. WEBSTER, et al. 1984. Influenza virus neuraminidase with hemagglutinin activity. Virology 137: 314-323.
10. CLAAS, E.C., A.D. OSTERHAUS, R. VAN BEEK, et al. 1998. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet 351: 472-477.
11. FOUCHIER, R.A., P.M. SCHNEEBERGER, F.W. ROZENDAAL, et al. 2004. Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proc. Natl. Acad. Sci. USA 101: 1356-1361.
12. SIMONSEN, L., M.J. CLARKE, G.D. WILLIAMSON, et al. 1997. The impact of influenza epidemics on mortality: introducing a severity index. Am. J. Public Health 87: 1944-1950.
13. SIMONSEN, L., K. FUKUDA, L.B. SCHONBERGER & N.J. COX. 2000. The impact of influenza epidemics on hospitalizations. J. Infect. Dis. 181: 831-837.
14. KOLATA, G. 2001. Flu: the Story of the Great Influenza Pandemic of 1918 & the Search for the Virus that Caused It. Touchstone Books. Kent, UK.
15. WRIGHT, P.F., J. THOMPSON & D.T. KARZON. 1980. Differing virulence of H1N1 and H3N2 influenza strains. Am. J. Epidemiol. 112: 814-819.
16. HAYDEN, F.G., R. FRITZ, M.C. LOBO, et al. 1998. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J. Clin. Invest. 101: 643-649.
17. PRICE, G.E., R.J. FENTON, H. SMITH & C. SWEET. 1997. Are known pyrogenic cytokines responsible for fever in influenza? J. Med. Virol. 52: 336-340.
18. SKONER, D.P., D.A. GENTILE, A. PATEL & W.J. DOYLE. 1999. Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus. J. Infect. Dis. 180: 10-14.
19. THOMPSON, W.W., D.K. SHAY, E. WEINTRAUB, et al. 2003. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289: 179-186.
20. MULLOOLY, J.P., M.D. BENNETT, M.C. HORNBROOK, et al. 1994. Influenza vaccination programs for elderly persons: cost-effectiveness in a health maintenance organization. Ann. Intern. Med. 121: 947-952.
21. WILLIAMS, W.W., M.A. HICKSON, M.A. KANE, et al. 1988. Immunization policies and vaccine coverage among adults. The risk for missed opportunities. Ann. Intern. Med. 108: 616-625.
22. MMWR. 2006. Update: influenza activity - United States and worldwide, 2005-06 season, and composition of the 2006-2007 influenza vaccine. MMWR Morb. Mortal Wkly. Rep. 55: 648-653.
23. WILDE, J.A., J.A. MCMILLAN, J. SERWINT, et al. 1999. Effectiveness of influenza vaccine in health care professionals: a randomized trial. JAMA 281: 908-913.
24. TARGONSKI, P.V., R.M. JACOBSON & G.A. POLAND. 2007. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 25: 3066-3069.
25. BERNSTEIN, E., D. KAYE, E. ABRUTYN, et al. 1999. Immune response to influenza vaccination in a large healthy elderly population. Vaccine 17: 82-94.
26. GROSS, P.A., R.A. LEVANDOWSKI, C. RUSSO, et al. 1994. Vaccine immune response and side effects with the use of acetaminophen with influenza vaccine. Clin. Diagn. Lab. Immunol. 1: 134-138.
27. GROSS, P.A., G.V. QUINNAN, JR., M.E. WEKSLER, et al. 1989. Relation of chronic disease and immune response to influenza vaccine in the elderly. Vaccine 7: 303-308.
28. LINA, B., M.A. FLETCHER, M. VALETTE, et al. 2000. A TritonX-100-split virion influenza vaccine is safe and fulfills the committee for proprietary medicinal products (CPMP) recommendations for the European Community for Immunogenicity, in Children, Adults and the Elderly. Biologicals 28: 95-103.
29. MCELHANEY JE, G.S. MENEILLY, K.E. LECHELT, et al. 1993. Antibody response to whole-virus and split-virus influenza vaccines in successful ageing. Vaccine 11: 1055-1060.
30. MURASKO, D.M., E.D. BERNSTEIN, E.M. GARDNER, et al. 2002. Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly. Exp. Gerontol. 37: 427-439.
31. MUSZKAT, M., G. FRIEDMAN, H.D. DANNENBERG, et al. 2003. Response to influenza vaccination in community and in nursing home residing elderly: relation to clinical factors. Exp. Gerontol. 38: 1199-1203.
32. SQUARCIONE, S., S. SGRICIA, L.R. BIASIO & E. PERINETTI. 2003. Comparison of the reactogenicity and immunogenicity of a split and a subunit-adjuvanted influenza vaccine in elderly subjects. Vaccine 21: 1268-1274.
33. VAN HOECKE, C, V. PRIKAZSKY, I. UTO & C. MENSCHIKOWSKI. 1996. Immunogenicity of an inactivated split influenza vaccine in institutionalized elderly patients. Gerontology 42: 190-198.
34. GOODWIN, K., C. VIBOUD & L. SIMONSEN. 2006. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 24: 1159-1169.
35. IORIO, A.M., M. NERI, E. LEPRI, et al. 2006. An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home. Vaccine 24: 6615-6619.
36. PATRIARCA, P.A., J.A. WEBER, M.K. MEISSNER, et al. 1985. Use of influenza vaccine in nursing homes. J. Am. Geriatr. Soc. 33: 463-466.
37. PATRIARCA, P.A., J.A. WEBER, R.A. PARKER, et al. 1985. Efficacy of influenza vaccine in nursing homes. Reduction in illness and complications during an influenza A (H3N2) epidemic. JAMA 253: 1136-1139.
38. GRAVENSTEIN, S., P. DRINKA, E.H. DUTHIE, et al. 1994. Efficacy of an influenza hemagglutinin-diphtheria toxoid conjugate vaccine in elderly nursing home subjects during an influenza outbreak. J. Am. Geriatr. Soc. 42: 245-251.
39. MCELHANEY, J.E. 2005. The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine 23(Suppl 1): S10-S25.
40. GROSS, P.A., G.V. QUINNAN, JR., M.E. WEKSLER, et al. 1988. Immunization of elderly people with high doses of influenza vaccine. J. Am. Geriatr. Soc. 36: 209-212.
41. KEITEL, W.A., T.R. CATE, R.L. ATMAR, et al. 1996. Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly. Clin. Diagn. Lab. Immunol. 3: 507-510.
42. ATMAR, R.L., W.A. KEITEL, T.R. CATE, et al. 2007. A dose-response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adults. Vaccine 25: 5367-5373.
43. GUEBRE-XABIER M, S.A. HAMMOND, L.R. ELLINGSWORTH & G.M. GLENN. Immunostimulant patch enhances immune responses to influenza virus vaccine in aged mice. J. Virol. 78: 7610-7618.
44. ERSHLER, W.B., A.L. MOORE, M.P. HACKER, et al. 1984. Specific antibody synthesis in vitro. II. Age-associated thymosin enhancement of antitetanus antibody synthesis. Immunopharmacology 8: 69-77.
45. ERSHLER, W.B., A.L. MOORE & M.A. SOCINSKI. 1984. Influenza and aging: agerelated changes and the effects of thymosin on the antibody response to influenza vaccine. J. Clin. Immunol. 4: 445-454.
46. ERSHLER, W.B., A.L. MOORE & M.A. SOCINSKI. 1985. Specific antibody synthesis in vitro. III. Correlation of in vivo and in vitro antibody response to influenza immunization in young and old subjects. J. Clin. Lab. Immunol. 16: 63-67.
47. ERSHLER, W.B., J.C. HEBERT, A.J. BLOW, et al. 1985. Effect of thymosin alpha one on specific antibody response and susceptibility to infection in young and aged mice. Int. J. Immunopharmacol. 7: 465-471.
48. GRAVENSTEIN, S., W.B. ERSHLER & M. WEKSLER. 1986. Anti-influenza antibody response: augmentation in elderly 'non-responders' by thymosin alpha 1. Gerontologist 26: 150a.
49. GRAVENSTEIN, S., E.H. DUTHIE, B.A. MILLER, et al. 1989. Augmentation of influenza antibody response in elderly men by thymosin alpha one. A double-blind placebo-controlled clinical study. J. Am. Geriatr. Soc. 37: 1-8.
50. MCCONNELL L, S. GRAVENSTEIN, E. ROECKER, et al. 1989. Augmentation of influenza antibody levels and reduction in attack rates in elderly subjects by thymosin alpha 1. Gerontologist 29: 188A.
51. EFFROS, R.B., A. CASILLAS & R.L. WALFORD. 1988. The effect of thymosin alpha 1 on immunity to influenza in aged mice. Aging Immunol. Infect. Dis. 1: 31-40.