Regulation of Apoptosis by Androgens in Prostate Cancer Cells

Methods in Molecular Biology

Volumn 776, Issue , 2011, Pages 349-360

  Arnoldussen, Yke Jildouw ^a   Wang, Ling ^a   Saatcioglu, Fahri ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Androgens; apoptosis; flow cytometry; fluorescence microscopy; prostate cancer; TUNEL

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROGEN; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; THAPSIGARGIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; DNA FRAGMENTATION; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; MALE; METABOLISM; NICK END LABELING; PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

ANDROGENS; APOPTOSIS; CELL LINE, TUMOR; CHROMONES; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MALE; MICROSCOPY, FLUORESCENCE; MORPHOLINES; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; THAPSIGARGIN; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 80052924465     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-243-4_20     Document Type: Chapter

References (10)

1. Krysko, D. V., Vanden Berghe, T., D’Herde, K., and Vandenabeele, P. (2008) Apoptosis and necrosis: detection, discrimination and phagocytosis, Methods 44, 205–221.
2. Orrenius, S., Nicotera, P., and Zhivotovsky, B. (2010) Cell death mechanisms and their implications in toxicology, Toxicol Sci 119, 3–19.
3. Heinlein, C. A., and Chang, C. (2004) Androgen receptor in prostate cancer, Endocrine Rev 25, 276–308.
4. Kaarbo, M., Klokk, T. I., and Saatcioglu, F. (2007) Androgen signaling and its interactions with other signaling pathways in prostate cancer, Bioessays 29, 1227–1238.
5. Lorenzo, P. I., and Saatcioglu, F. (2008) Inhibition of apoptosis in prostate cancer cells by androgens is mediated through downregulation of c-Jun N-terminal kinase activation, Neoplasia 10, 418–428.
6. Engedal, N., Korkmaz, C. G., and Saatcioglu, F. (2002) C-Jun N-terminal kinase is required for phorbol ester-and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP, Oncogene 21, 1017–1027.
7. Sah, N. K., Munshi, A., Kurland, J. F., McDonnell, T. J., Su, B., and Meyn, R. E. (2003) Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase, J Biol Chem 278, 20593–20602.
8. Arnoldussen, Y. J., Lorenzo, P. I., Preto-rius, M. E., Waehre, H., Risberg, B., Maelandsmo, G. M., Danielsen, H. E., and Saatcioglu, F. (2008) The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer, Cancer Res 68, 9255–9264.
9. Lorenzo, P. I., Arnoldussen, Y. J., and Saatcioglu, F. (2007) Molecular mechanisms of apoptosis in prostate cancer, Crit Rev Oncogen 13, 1–38.
10. Wang, L., Jin, Y., Arnoldussen, Y. J., Jonson, I., Qu, S., Maelandsmo, G. M., Kristian, A., Risberg, B., Waehre, H., Danielsen, H. E., and Saatcioglu, F. (2010) STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer, Cancer Res 70, 5818–5828.