Increased mortality among publicly insured participants in the HIV Outpatient Study despite HAART treatment

AIDS

Volumn 25, Issue 15, 2011, Pages 1865-1876

  Palella Jr , Frank J ^a   Baker, Rose K ^b   Buchacz, Kate ^c   Chmiel, Joan S ^a   Tedaldi, Ellen M ^d   Novak, Richard M ^e   Durham, Marcus D ^c   Brooks, John T ^c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b CERNER CORPORATION   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d TEMPLE UNIVERSITY   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

HAART; insurance; mortality; race ethnicity

Indexed keywords

CD4 ANTIGEN; INTEGRASE INHIBITOR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS RNA;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CD4 LYMPHOCYTE COUNT; CHRONIC HEPATITIS; COMORBIDITY; ETHNICITY; FEMALE; FOLLOW UP; HAZARD RATIO; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY DYSFUNCTION; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY (TOPIC); OBSERVATIONAL STUDY; OUTPATIENT; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; SURVIVAL; TREATMENT DURATION; VIRUS TRANSMISSION;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COMORBIDITY; FEMALE; HIV INFECTIONS; HUMANS; INSURANCE, HEALTH; MALE; MIDDLE AGED; ODDS RATIO; OUTPATIENTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PUBLIC SECTOR; SURVIVAL ANALYSIS; UNITED STATES;

EID: 80052922531     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32834b3537     Document Type: Article

References (20)

1. Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338:853-860. (Pubitemid 28135961)
2. Palella FJ Jr, Baker RK, Moorman AC, Chmiel JS, Wood KC, Brooks JT, Holmberg SD. Mortality in the highly active anti-retroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr 2006; 43:27-34. (Pubitemid 44306484)
3. Hessol NA, Kalinowski A, Benning L, Mullen J, Young M, Palella F, et al. Mortality among participants in the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study. Clin Infect Dis 2007; 44:287-294. (Pubitemid 46079997)
4. Bhaskaran K, Hamouda O, Sannes M, Boufassa F, Johnson AM, Lambert PC, Porter K. Changes in the risk of death after HIV seroconversion compared with mortality in the general population. JAMA 2008; 300:51-59. (Pubitemid 351920404)
5. Welch KJ, Morse A. Survival patterns among HIVRindividuals based on healthcare utilization. J Natl Med Assoc 2001; 93:214-219. (Pubitemid 33603537)
6. Losina E, Schackman BR, Sadownik SN, Gebo KA, Walensky RP, Chiosi JJ, et al. Racial and sex disparities in life expectancy losses among HIV-infected persons in the United States: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapy. Clin Infect Dis 2009; 49:1570-1578.
7. Lemly DC, Shepherd BE, Hulgan T, Rebeiro P, Stinnette S, Blackwell RB, et al. Race and sex differences in antiretroviral therapy use and mortality among HIV-infected persons in care. J Infect Dis 2009; 199:991-998.
8. Mugavero MJ, Lin HY, Allison JJ, Giordano TP, Willig JH, Raper JL, et al. Racial disparities in HIV virologic failure: do missed visits matter? J Acquir Immune Defic Syndr 2009; 50:100-108.
9. Silverberg MJ, Leyden W, Quesenberry CP Jr, Horberg MA. Race/ethnicity and risk of AIDS and death among HIV-infected patients with access to care. J Gen Intern Med 2009; 24: 1065-1072.
10. Weintrob AC, Grandits GA, Agan BK, Ganesan A, Landrum ML, Crum-Cianflone NF, et al. Virologic response differences between African Americans and European Americans initiating highly active antiretroviral therapy with equal access to care. J Acquir Immune Defic Syndr 2009; 52:574-580.
11. Mugavero MJ, Lin HY, Willig JH, Westfall AO, Ulett KB, Rout-man JS, et al. Missed visits and mortality among patients establishing initial outpatient HIV treatment. Clin Infect Dis 2009; 48:248-256.
12. Buchacz K, Baker RK, Moorman AC, Richardson JT, Wood KC, Holmberg SD, Brooks JT. Rates of hospitalizations and associated diagnoses in a large multisite cohort of HIV patients in the United States, 1994-2005. AIDS 2008; 22:1345-1354.
13. Crum NF, Riffenburgh RH, Wegner S, Agan BK, Tasker SA, Spooner KM, et al. Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre, early, and late HAART (highly active antiretroviral therapy) eras. J Acquir Immune Defic Syndr 2006; 41:194-200.
14. Sabin CA, Smith CJ, Youle M, Lampe FC, Bell DR, Puradiredja D, et al. Deaths in the era of HAART: contribution of late presentation, treatment exposure, resistance and abnormal laboratory markers. AIDS 2006; 20:67-71. (Pubitemid 41818116)
15. Marin B, Thiebaut R, Bucher HC, Rondeau V, Costagliola D, Dorrucci M, et al. Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy. AIDS 2009; 23:1743-1753.
16. Neuhaus J, Angus B, Kowalska JD, La Rosa A, Sampson J, Wentworth D, Mocroft A. Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV. AIDS 2010; 24:697-706.
17. Justice AC. Prioritizing primary care in HIV: comorbidity, toxicity, and demography. Top HIV Med 2006; 14:159-163.
18. Centers for Disease Control and Prevention (CDC). Electronic record linkage to identify deaths among persons with AIDS-District of Columbia, 2000-2005. MMWR Morb Mortal Wkly Rep 2008; 57:631-634.
19. Hooshyar D, Hanson DL, Wolfe M, Selik RM, Buskin SE, McNaghten AD. Trends in perimortal conditions and mortality rates among HIV-infected patients. AIDS 2007; 21:2093-2100. (Pubitemid 47462159)
20. Rcounts greater than 200 cells/mm3. J Acquir Immune Defic Syndr 2007; 44:179-187. (Pubitemid 46292221)