Inhibition of x c - Transporter-mediated cystine uptake by sulfasalazine analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6184-6187

  Shukla, Krupa ^a   Thomas, Ajit G ^b   Ferraris, Dana V ^b   Hin, Niyada ^b   Sattler, Rita ^a,b   Alt, Jesse ^b   Rojas, Camilo ^b   Slusher, Barbara S ^a,b   Tsukamoto, Takashi ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Antiporter; Glutamate; Sulfasalazine; System x c cystine

Indexed keywords

2 HYDROXY 5 [[4 (N PYRIDIN 2 YLSULFAMOYL)PHENYL]ETHYNYL]BENZOIC ACID; ALKYNE DERIVATIVE; ANTIPORTER; AZO COMPOUND; CARBOXYLIC ACID; CYSTINE; GLUTAMIC ACID; HYDROXYL GROUP; PHENOL DERIVATIVE; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; GLUTAMATE TRANSPORTER;

ARTICLE; CHEMICAL BOND; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION; CELL LINE; DRUG ANTAGONISM; METABOLISM;

AMINO ACID TRANSPORT SYSTEM X-AG; ANTIPORTERS; CELL LINE; CYSTINE; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFASALAZINE;

EID: 80052916095     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.081     Document Type: Article

References (22)

1. M. Lo, Y.Z. Wang, and P.W. Gout J. Cell Physiol 215 2008 593
2. H. Sontheimer J Neurochem 105 2008 287
3. N.E. Savaskan, E. Hahnen, and I.Y. Eyupoglu J. Cell Physiol 220 2009 531
4. Z.C. Ye, J.D. Rothstein, and H. Sontheimer J. Neurosci 19 1999 10767
5. P.W. Gout, A.R. Buckley, C.R. Simms, and N. Bruchovsky Leukemia 15 2001 1633
6. D.W. Doxsee, P.W. Gout, T. Kurita, M. Lo, A.R. Buckley, Y. Wang, H. Xue, C.M. Karp, J.C. Cutz, G.R. Cunha, and Y.Z. Wang Prostate 67 2007 162
7. J. Guan, M. Lo, P. Dockery, S. Mahon, C.M. Karp, A.R. Buckley, S. Lam, P.W. Gout, and Y.Z. Wang Cancer Chemother. Pharmacol. 64 2009 463
8. M. Lo, V. Ling, Y.Z. Wang, and P.W. Gout Br. J. Cancer. 99 2008 464
9. Z.C. Ye, and H. Sontheimer Glia 25 1999 270
10. W.J. Chung, S.A. Lyons, G.M. Nelson, H. Hamza, C.L. Gladson, G.Y. Gillespie, and H. Sontheimer J. Neurosci. 25 2005 7101
11. N.E. Savaskan, A. Heckel, E. Hahnen, T. Engelhorn, A. Doerfler, O. Ganslandt, C. Nimsky, M. Buchfelder, and I.Y. Eyupoglu Nat. Med. 14 2008 629
12. Y. Hayashi, N. Sekiyama, S. Nakanishi, D.E. Jane, D.C. Sunter, E.F. Birse, P.M. Udvarhelyi, and J.C.J. Watkins Neurosci. 14 1994 3370
13. A.K. Azadkhan, S.C. Truelove, and J.K. Aronson Br. J. Clin. Pharmacol 13 1982 523
14. S.A. Patel, T. Rajale, E. O'Brien, D.J. Burkhart, J.K. Nelson, B. Twamley, A. Blumenfeld, M.I. Szabon-Watola, J.M. Gerdes, R.J. Bridges, and N.R. Natale Bioorg. Med. Chem. 18 2010 202
15. J.L. Etoga, S.K. Ahmed, S. Patel, R.J. Bridges, and C.M. Thompson Bioorg. Med. Chem. Lett. 20 2010 2680
16. Agback, H.; Ahrgren, L.; Berglindh, T.; Haraldsson, M.; Smedegard, G.; Olsson, L.-I. U.S. Patent 5,302,718, 1994.
17. S.A. Patel, B.A. Warren, J.F. Rhoderick, and R.J. Bridges Neuropharmacology 46 2004 273
18. Sontheimer, H. J.; Ye, Z.-c. U.S. Patent 6,197,820, 2001.
19. G.E. Gochenauer, and M.B. Robinson J. Neurochem 78 2001 276
20. D.A. Baker, Z.X. Xi, H. Shen, C.J. Swanson, and P.W. Kalivas J. Neurosci 22 2002 9134
21. I. Phlman, M. Wilen, and S. Bowald J. Pharm Pharmacol 51 1999 61
22. The use of susalimod as an inhibitor of system x c - was first suggested in Chung, J. W.; Sontheimer, H. J. WO 2006049957, 2006.