The Lognormal Perfusion Model for Disruption Replenishment Measurements of Blood Flow: In Vivo Validation

Ultrasound in Medicine and Biology

Volumn 37, Issue 10, 2011, Pages 1571-1578

  Hudson, John M ^a,b   Leung, Kogee ^b   Burns, Peter N ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Disruption replenishment; Mono exponential model; Perfusion measurement; Ultrasound contrast agents

Indexed keywords

BLOOD FLOW; CONFIDENCE INTERVAL; DISRUPTION-REPLENISHMENT; DYNAMIC CONTRAST; IN-VIVO; LOG-NORMAL; MICROBUBBLE CONTRAST AGENTS; PERFUSION MEASUREMENTS; PERFUSION MODELS; RABBIT KIDNEY; TISSUE PERFUSION; TRANSIT TIME; ULTRASOUND CONTRAST AGENT; ULTRASOUND IMAGING;

BIOLOGICAL ORGANS; FLOW MEASUREMENT; TISSUE; ULTRASONIC IMAGING; ULTRASONICS;

FLOWMETERS;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOWMETRY; CLINICAL ASSESSMENT; CONTROLLED STUDY; FLOW KINETICS; GOLD STANDARD; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; KIDNEY PLASMA FLOW; LIMIT OF QUANTITATION; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPRODUCIBILITY; VALIDATION PROCESS;

ALGORITHMS; ANIMALS; BLOOD FLOW VELOCITY; BLOOD VOLUME; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; FLUOROCARBONS; HEMORHEOLOGY; KIDNEY; LEAST-SQUARES ANALYSIS; RABBITS; RENAL ARTERY OBSTRUCTION; REPRODUCIBILITY OF RESULTS; STATISTICS, NONPARAMETRIC;

EID: 80052906635     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2011.06.009     Document Type: Article

References (28)

1. Arditi M., Frinking P.J., Zhou X., Rognin N.G. A new formalism for the quantification of tissue perfusion by the destruction-replenishment method in contrast ultrasound imaging. IEEE Trans Ultrason Ferroelectr Freq Control 2006, 53:1118-1129.
2. Averkiou M.A., Lampaskis M., Kyriakopoulou K., Skarlos D., Klouvas G., Strouthos C., Leen E.L. Quantification of tumor microvascularity with respiratory gated contrast enhanced ultrasound for monitoring therapy. Ultrasound Med Biol 2010, 36:68-77.
3. Carr C., Lindner J. Myocardial perfusion imaging with contrast echocardiography. Echocardiography 2008, 10:233-239.
4. Christopher P., Parker K. New approaches to nonlinear diffractive field propagation. J Acoustic Soc Am 1991, 90:488-499.
5. Cobbold R. Foundations of biomedical ultrasound 2007, Oxford University Press, New York.
6. Crow E.L., Shimizu K. Lognormal distributions 1988, Marcel Dekker, Inc., New York.
7. Gauthier TP, Averkiou MA, Leen ELS. Perfusion quantification using dynamic contrast-enhanced ultrasound: The impact of dynamic range and gain on time-intensity curves Ultrasonics 2011;51:102-106.
8. Goertz D.E., de Jong N., van der Steen A.F. Attenuation and size distribution measurements of definity and manipulated definity populations. Ultrasound Med Biol 2007, 33:1376-1388.
9. Hudson J.M., Karshafian R., Burns P.N. Quantification of flow using ultrasound and microbubbles: A disruption replenishment model based on physical principles. IEEE Ultrason Symp 2006, 1588-1591.
10. Hudson J.M., Karshafian R., Burns P.N. Quantification of flow using ultrasound and microbubbles: A disruption replenishment model based on physical principles. Ultrasound Med Biol 2009, 35:2007-2020.
11. Hudson J.M., Williams R., Atri M., Kim T.K., Bjarnason G.A., Burns P.N. Improved flow measurement using microbubble contrast agents and disruption-replenishment: Clinical application to tumour monitoring. Ultrasound Med Biol 2011, (in press).
12. Karshafian R., Burns P., Henkelman M. Transit time kinetics in ordered and disordered vascular trees. Phys Med Biol 2003, 48:3225-3237.
13. Krix M., Kiessling F., Farhan N., Schmidt K., Hoffend J., Delorme S. A multivessel model describing replenishment kinetics of ultrasound contrast agent for quantification of tissue perfusion. Ultrasound Med Biol 2003, 29:1421-1430.
14. Lampaskis M., Averkiou M. Investigation of the relationship of nonlinear backscattered ultrasound intensity with microbubble concentration at low MI. Ultrasound Med Biol 2010, 36:306-312.
15. Lamuraglia M., Bridal S.L., Santin M., Izzi G., Rixe O., Paradiso A., Lucidarme O. Clinical relevance of contrast-enhanced ultrasound in monitoring anti-angiogenic therapy of cancer: Current status and perspectives. Crit Rev Oncol Hematol 2010, 73:202-212.
16. Lindner J.R., Villanueva F.S., Dent J.M., Wei K., Sklenar J., Kaul S. Assessment of resting perfusion with myocardial contrast echocardiography: Theoretical and practical considerations. Am Heart J 2000, 139:231-240.
17. Lucidarme O., Franchi-Abella S., Correas J.M., Bridal S.L., Kurtisovski E., Berger G. Blood flow quantification with contrast-enhanced US: "Entrance in the section" phenomenon-phantom and rabbit study. Radiology 2003, 228:473-479.
18. Molls M., Vaupel P. Blood perfusion and microenvironment of human tumors: Implications for clinical radiooncology 1998, Springer-Verlag, Berlin.
19. Potdevin T.C., Fowlkes J.B., Moskalik A.P., Carson P.L. Analysis of refill curve shape in ultrasound contrast agent studies. Med Phys 2004, 31:623-632.
20. Potdevin T.C., Fowlkes J.B., Moskalik A.P., Carson P.L. Refill model of rabbit kidney vasculature. Ultrasound Med Biol 2006, 32:1331-1338.
21. Prinzen F., Bassingthwaighte J. Blood flow distributions by microsphere deposition methods. Cardiovasc Res 2000, 45:13-21.
22. Qian H., Bassingthwaighte J.B. A class of flow bifurcation models with lognormal distribution and fractal dispersion. J Theor Biol 2000, 205:261-268.
23. Rim S., Leong-Poi H., Lindner J., Couture D., Ellegala D., Mason H., Durieux M., Kassel N., Kaul S. Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound. Circulation 2001, 104:2582-2587.
24. Stride E., Tang M., Eckersley R.J. Physical phenomena affecting quantitative imaging of ultrasound contrast agents. Appl Acoust 2009, 70:1352-1362.
25. Talu E., Hettiarachchi K., Zhao S., Powell R.L., Lee A.P., Longo M.L., Dayton P.A. Tailoring the size distribution of ultrasound contrast agents: Possible method for improving sensitivity in molecular imaging. Mol Imaging 2007, 6:384-392.
26. Tang M., Mari J., Wells P., Eckersley R.J. Attenuation correction in ultrasound contrast agent imaging: Elementary theory and preliminary experimental evaluation. Ultrasound Med Biol 2010, 34:1998-2008.
27. Wei K., Jayaweera A., Firoozan S., Linka A., Skyba D., Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998, 97:473-483.
28. Zemp R., Tavakkoli J., Cobbold R. Modeling of nonlinear ultrasound propagation in tissue from array transducers. J Acoust Soc Am 2003, 113:139-152.