Identification of thiosildenafil in a health supplement

Natural Product Communications

Volumn 6, Issue 7, 2011, Pages 1003-1004

  Nicoletti, Marcello ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Dietary supplement; HPTLC; NMR; Sildenafil; Thiosildenafil

Indexed keywords

AGENTS ACTING ON THE GENITAL SYSTEM; THIOSILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; DIET SUPPLEMENTATION; DRUG DETERMINATION; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MARKETING; DRUG SAFETY; DRUG STRUCTURE; DRUG USE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; SPECTROSCOPY;

EID: 80052893578     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1100600721     Document Type: Article

References (7)

1. Balayssac S, Trefi S, Gilard V, Malet-Martino M, Martino R, Delsuc M-A. (2009) 2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: Application to herbal drugs or dietary supplements for erectile dysfunction. Journal of Pharmaceutical and Biomedical Analysis, 50, 602-612.
2. Blok-Tip L, Zomer B, Bakker F, Hartog KD, Hamzink M, ten Hove J, Vredenbregt M, de Kaste D. (2004) Structure elucidation of sildenafil analogues in herbal products. Food Additives and Contamination, 21, 737-748.
3. Singh S, Prasad B, Savaliya AA, Shah RP, Gohil VM, Kaur A (2009) Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs. Trends in Analytical Chemistry, 28, 13-26.
4. Daraghmeh N, Al-Omari M, Badwan AA, Jaber AMY. (2001) Determination of sildenafil citrate and related substances in the commercial products and tablet dosage form using HPLC. Journal of Pharmaceutical and Biomedical Analysis, 25, 483-491.
5. Wawer I, Pisklak M, Chilmonczyk Z. (2005) 1H, 13C, 15N NMR analysis of sildenafil base and citrate (Viagra) in solution, solid state and pharmaceutical dosage forms. Journal of Pharmaceutical and Biomedical Analysis, 38, 865-870. (Pubitemid 41115793)
6. Park HJ, Jeong HK, Chang MI, IM MH, Jeong JY, Choi DM, Park K, Hong MK, Youm J, Han SB, Kim DJ, Park JH, Kwon SW. (2007) Structure determination of new analogues of verdenafil and sildenafil in dietary supplements. Food Additives and Contaminations, 24, 122-129. (Pubitemid 46957589)
7. Trefi S, Gilard V, Balayssac S, Malet-Martino M, Martino R. (2009) The usefulness of 2D DOSY and 3D DOSY-COSY 1H NMR for mixture analysis: application to genuine and fake formulations of sildenafil (Viagra). Magnetic Resonance in Chemistry, 47, S163-173.