How are thiopurines used and monitored by Swedish gastroenterologists when treating patients with inflammatory bowel disease?

Scandinavian Journal of Gastroenterology

Volumn 46, Issue 10, 2011, Pages 1215-1221

  Hindorf, Ulf ^a   Andersson, Philip ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

6 mercaptopurine; Azathioprine; Inflammatory bowel disease; Questionnaires; Thiopurine methyltransferase

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; ALLOPURINOL; AZATHIOPRINE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ARTICLE; BONE MARROW TOXICITY; CLINICAL PRACTICE; CROHN DISEASE; DRUG EFFICACY; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENTERITIS; FEMALE; HUMAN; IMMUNOMODULATION; LEUKOPENIA; MALE; MEDICAL SPECIALIST; METABOLITE; PRIORITY JOURNAL; SWEDEN; TREATMENT DURATION; ULCERATIVE COLITIS;

ALLOPURINOL; ANTIBODIES, MONOCLONAL; ANTIMETABOLITES; AZATHIOPRINE; DRUG THERAPY, COMBINATION; FEMALE; GASTROENTEROLOGY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; MALE; METHYLTRANSFERASES; MYCOPHENOLIC ACID; PHYSICIAN'S PRACTICE PATTERNS; QUESTIONNAIRES; SWEDEN; TACROLIMUS; THIOGUANINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052891355     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2011.603162     Document Type: Article

References (23)

1. Lindqvist M, Hindorf U, Almer S, Peterson C. Thiopurines in inflammatory bowel disease - the role of pharmacogenetics and therapeutic drug monitoring. Curr Pharmacogenet 2006; 4:285-300. (Pubitemid 44890530)
2. Hawthorne AB, Logan RF, Hawkey CJ, Foster PN, Axon AT, Swarbrick ET, et al. Randomised controlled trial of azathioprine withdrawal in ulcerative colitis. BMJ 1992; 305:20-2.
3. Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A metaanalysis. Ann Intern Med 1995;123:132-42.
4. Ford LT, Berg JD. Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come. J Clin Pathol 2010;63:288-95.
5. Reinshagen M, Schutz E, Armstrong VW, Behrens C, Von Tirpitz C, Stallmach A, et al. 6-thioguanine nucleotideadapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. Clin Chem 2007;53:1306-14. (Pubitemid 47020987)
6. Roblin X, Serre-Debeauvais F, Phelip JM, Faucheron JL, Hardy G, Chartier A, et al. 6-tioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine. Aliment Pharmacol Ther 2005;21: 829-39. (Pubitemid 40477243)
7. Hindorf U, Lindqvist M, Peterson C, Soderkvist P, Strom M, Hjortswang H, et al. Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease. Gut 2006;55:1423-31. (Pubitemid 44476786)
8. Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Theoret Y, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000;118: 705-13. (Pubitemid 30171620)
9. Almer S, Befrits R, Eriksson AS, Halfvarson J, Hindorf U, Lofberg R. Modern läkemedelsterapi vid Crohn-nationella riktlinjer. Current drug therapy in Crohn disease-national guidelines]. Läkartidningen 2009;106:2988-93.
10. Hindorf U, Johansson M, Eriksson A, Kvifors E, Almer SH. Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2009;29:654-61.
11. Baumgart DC, Pintoffl JP, Sturm A, Wiedenmann B, Dignass AU. Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease-a long-term follow-up. Am J Gastroenterol 2006;101:1048-56. (Pubitemid 43725319)
12. Neurath MF, Wanitschke R, Peters M, Krummenauer F, Meyer zum Buschenfelde KH, Schlaak JF. Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohns disease. Gut 1999;44:625-8. (Pubitemid 29195908)
13. Almer SH, Hjortswang H, Hindorf U. 6-Thioguanine therapy in Crohns disease-observational data in Swedish patients. Dig Liver Dis 2009;41:194-200.
14. Sparrow MP, Hande SA, Friedman S, Cao D, Hanauer SB. Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol 2007;5: 209-14. (Pubitemid 46216945)
15. Yip JS, Woodward M, Abreu MT, Sparrow MP. How are Azathioprine and 6-mercaptopurine dosed by gastroenterologists? Results of a survey of clinical practice. Inflamm Bowel Dis 2008;14:514-8. (Pubitemid 351571831)
16. Roblin X, Oussalah A, Chevaux JB, Sparrow M, Peyrin-Biroulet L. Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts. Inflamm Bowel Dis 2011. doi:10.1002/ibd.21662. Epub ahead of print].
17. Peyrin-Biroulet L, Oussalah A, Roblin X, Sparrow MP. The use of azathioprine in Crohns disease during pregnancy and in the post-operative setting: a worldwide survey of experts. Aliment Pharmacol Ther 2011;33:707-13.
18. Tysk C, Almer S, Andersson MV, Befrits R, Hertervig E, Kilander A, et al. Handläggning av svrt skov av ulcerös kolit. Management of severe attack of ulcerative colitis]. Läkartidningen 2009;106:2994-8.
19. Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, et al. Infliximab, azathioprine, or combination therapy for Crohns disease. N Engl J Med 2010;362:1383-95.
20. Mahadevan U. Fertility and pregnancy in the patient with inflammatory bowel disease. Gut 2006;55:1198-206. (Pubitemid 44085690)
21. Dejaco C, Mittermaier C, Reinisch W, Gasche C, Waldhoer T, Strohmer H, et al. Azathioprine treatment and male fertility in inflammatory bowel disease. Gastroenterology 2001;121:1048-53. (Pubitemid 33022083)
22. Fargher EA, Tricker K, Newman W, Elliott R, Roberts SA, Shaffer JL, et al. Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription. J Clin Pharm Ther 2007;32: 187-95. (Pubitemid 46449703)
23. Dewit O, Starkel P, Roblin X. Thiopurine metabolism monitoring: implications in inflammatory bowel diseases. Eur J Clin Invest 2010;40:1037-47.