Novel locus FER is associated with serum HMW adiponectin levels

Diabetes

Volumn 60, Issue 8, 2011, Pages 2197-2201

  Qi, Lu ^a,b   Menzaghi, Claudia ^c   Salvemini, Lucia ^c   De Bonis, Concetta ^c   Trischitta, Vincenzo ^a,c,d   Hu, Frank B ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; FEMALE; FER GENE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; METABOLIC DISORDER; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; ADULT; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MOLECULAR WEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 80052864661     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1645     Document Type: Article

References (25)

1. Pajvani UB, Du X, Combs TP, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 2003;278:9073-9085 (Pubitemid 36800387) (Pubitemid 36800387)
2. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-1295 (Pubitemid 35373562) (Pubitemid 35373562)
3. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7:947-953
4. Menzaghi C, Salvemini L, Paroni G, et al. Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic white Caucasians from Italy: evidence from a family-based study. J Intern Med 2010;267:287-294
5. Fisher FF, Trujillo ME, Hanif W, et al. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 2005;48:1084-1087 (Pubitemid 40909642) (Pubitemid 40909642)
6. Hara K, Horikoshi M, Yamauchi T, et al. Measurement of the highmolecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 2006;29:1357-1362 (Pubitemid 44125935) (Pubitemid 44125935)
7. Cesari M, Narkiewicz K, De Toni R, Aldighieri E, Williams CJ, Rossi GP. Heritability of plasma adiponectin levels and body mass index in twins. J Clin Endocrinol Metab 2007;92:3082-3088 (Pubitemid 47236374) (Pubitemid 47236374)
8. Menzaghi C, Trischitta V, Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 2007;56:1198-1209 (Pubitemid 46715598) (Pubitemid 46715598)
9. Qi L, Li T, Rimm E, et al. The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes 2005;54:1607-1610 (Pubitemid 40586698) (Pubitemid 40586698)
10. Richards JB, Waterworth D, O'Rahilly S, et al.; GIANT Consortium. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009;5:e1000768
11. Jee SH, Sull JW, Lee JE, et al. Adiponectin concentrations: a genome-wide association study. Am J Hum Genet 2010;87:545-552
12. Wu Y, Li Y, Lange EM, et al. Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet 2010;19:4955-4964
13. Heid IM, Henneman P, Hicks A, et al. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2010;208: 412-420
14. Ling H, Waterworth DM, Stirnadel HA, et al. Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring) 2009;17:737-744
15. Kangas-Kontio T, Huotari A, Ruotsalainen H, et al. Genetic and environmental determinants of total and high-molecular weight adiponectin in families with low HDL-cholesterol and early onset coronary heart disease. Atherosclerosis 2010;210:479-485
16. Qi L, Kang K, Zhang C, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008;57:3145-3151
17. Qi L, Cornelis MC, Kraft P, et al.; Meta-Analysis of Glucose and Insulinrelated traits Consortium (MAGIC); Diabetes Genetics Replication and Metaanalysis (DIAGRAM) Consortium. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet 2010;19:2706-2715
18. Qi L, Cornelis MC, Kraft P, et al. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet 2010;19:1856-1862
19. Li Y, Willer C, Sanna S, Abecasis G. Genotype imputation. Annu Rev Genomics Hum Genet 2009;10:387-406
20. McCafferty DM, Craig AW, Senis YA, Greer PA. Absence of Fer proteintyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J Immunol 2002;168:4930-4935 (Pubitemid 34495954) (Pubitemid 34495954)
21. Greer P. Closing in on the biological functions of Fps/Fes and Fer. Nat Rev Mol Cell Biol 2002;3:278-289 (Pubitemid 34619263) (Pubitemid 34619263)
22. Middelberg RP, Gordon SD, Zhu G, et al. Linkage and association analyses of longitudinally measured lipid phenotypes in adolescence. Twin Res Hum Genet 2008;11:603-620
23. Menzaghi C, Ercolino T, Salvemini L, et al. Multigenic control of serum adiponectin levels: evidence for a role of the APM1 gene and a locus on 14q13. Physiol Genomics 2004;19:170-174 (Pubitemid 40039923) (Pubitemid 40039923)
24. Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev 2005;6:13-21
25. Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 2006;55:249-259 (Pubitemid 43343322) (Pubitemid 43343322)