Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients

Critical Care

Volumn 15, Issue 5, 2011, Pages

  Heming, Nicholas ^a   Faisy, Christophe ^a   Urien, Saïk ^b  

^a HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^b INSERM   (France)

Author keywords

COPD; Mechanical ventilation; Metabolic alkalosis; Weaning

Indexed keywords

ACETAZOLAMIDE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BICARBONATE; CHLORIDE; CORTICOSTEROID; CREATININE; FUROSEMIDE; OXYGEN; POTASSIUM; CARBONATE DEHYDRATASE INHIBITOR;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BICARBONATE BLOOD LEVEL; CHLORIDE BLOOD LEVEL; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER MODEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; FEMALE; HOME OXYGEN THERAPY; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; METABOLIC ALKALOSIS; OBSERVATIONAL STUDY; PHARMACODYNAMICS; POPULATION MODEL; POSITIVE END EXPIRATORY PRESSURE; POTASSIUM BLOOD LEVEL; PRESSURE SUPPORT VENTILATION; PRIORITY JOURNAL; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; VENTILATED PATIENT; ALKALOSIS; BIOLOGICAL MODEL; BLOOD; DRUG MONITORING; METABOLISM; MIDDLE AGED; TREATMENT OUTCOME;

ACETAZOLAMIDE; ADULT; AGED; AGED, 80 AND OVER; ALKALOSIS; BICARBONATES; CARBONIC ANHYDRASE INHIBITORS; DRUG MONITORING; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 80052859692     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10448     Document Type: Article

References (27)

1. Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, Schmid V, Buist S: Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J 2006, 27:397-412
2. Gunen H, Hacievliyagil SS, Kosar F, Mutlu LC, Gulbas G, Pehlivan E, Sahin I, Kizkin O: Factors affecting survival of hospitalised patients with COPD. Eur Respir J 2005, 26:234-241
3. Lightowler JV, Wedzicha JA, Elliott MW, Ram FS: Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis. BMJ 2003, 326:185
4. Gursel G: Determinants of the length of mechanical ventilation in patients with COPD in the intensive care unit. Respiration 2005, 72:61-67
5. Khanna A, Kurtzman NA: Metabolic alkalosis. Respir Care 2001, 46:354-365
6. Berthelsen P, Gøthgen I, Husum B, Jacobsen E: Oxygen uptake and carbon dioxide elimination after acetazolamide in the critically ill. Intensive Care Med 1985, 11:26-29
7. Brimioulle S, Berre J, Dufaye P, Vincent JL, Degaute JP, Kahn RJ: Hydrochloric acid infusion for treatment of metabolic alkalosis associated with respiratory acidosis. Crit Care Med 1989, 17:232-236
8. Swenson ER: Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression. Eur Respir J 1998, 12:1242-1247
9. Mazur JE, Devlin JW, Peters MJ, Jankowski MA, Iannuzzi MC, Zarowitz BJ: Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. Crit Care Med 1999, 27:1257-1261
10. Faisy C, Mokline A, Sanchez O, Tadié JM, Fagon JY: Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation. Intensive Care Med 2010, 36:859-863
11. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J, Global Initiative for Chronic Obstructive Pulmonary Disease: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007, 176:532-555
12. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T: Weaning from mechanical ventilation. Eur Respir J 2007, 29:1033-1056
13. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270:2957-2963
14. Yano I, Takayama A, Takano M, Inatani M, Tanihara H, Ogura Y, Honda Y, Inui K: Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation. Eur J Clin Pharmacol 1998, 54:63-68
15. Ritschel WA, Paulos C, Arancibia A, Agrawal MA, Wetzelsberger KM, Lücker PW: Pharmacokinetics of acetazolamide in healthy volunteers after short-and long-term exposure to high altitude. J Clin Pharmacol 1998, 38:533-539
16. Ihaka R, Gentleman R: R: a language for data analysis and graphics. J Comput Graphic Stat 1996, 5:299-314
17. Berthelsen P, Gøthgen I, Husum B, Jacobsen E: Dissociation of renal and respiratory effects of acetazolamide in the critically ill. Br J Anaesth 1986, 58:512-516
18. Teppema L, Dahan A: Acetazolamide and breathing: Does a clinical dose alter peripheral and central CO2 sensitivity? Am J Resp Crit Care Med 1999, 160:1592-1597
19. Kiwull-Schöne HF, Teppema LJ, Kiwull PJ: Low-dose acetazolamide does affect respiratory muscle function in spontaneously breathing anesthetized rabbits. Am J Respir Crit Care Med 2001, 163:478-483
20. Wagenaar M, Teppema L, Berkenbosch A, Olievier C, Folgering H: The effect of low-dose acetazolamide on the ventilatory CO2 response curve in the anaesthetized cat. J Physiol 1996, 495:227-237
21. Webster NR, Kulkarni V: Metabolic alkalosis in the critically ill. Crit Rev Clin Lab Sci 1999, 36:497-510
22. Uway Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther 2000, 295:261-265
23. Maren TH: Chemistry of the renal reabsorption of bicarbonate. Can J Physiol Pharmacol 1974, 52:1041-1050
24. Maren TH: Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol Rev 1967, 47:595-781
25. Preisig PA, Toto RD, Alpern RJ: Carbonic anhydrase inhibitors. Ren Physiol 1987, 10:136-159
26. Skatrud JB, Dempsey JA: Relative effectiveness of acetazolamide versus medroxyprogesterone acetate in correction of chronic carbon dioxide retention. Am Rev Respir Dis 1983, 127:405-412
27. Groenewegen KH, Scholas AM, Wouters EF: Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD. Chest 2003, 124:459-467