Acetazolamide and breathing: Does a clinical dose alter peripheral and central CO2 sensitivity?

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 5 I, 1999, Pages 1592-1597

  Teppema, Luc J ^a   Dahan, Albert ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; OXYGEN;

ADULT; ALKALOSIS; ARTICLE; BLOOD GAS; BREATHING; CARBON DIOXIDE TENSION; CHEMORECEPTOR REFLEX; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; END TIDAL CARBON DIOXIDE TENSION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC ACIDOSIS; NORMAL HUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032717678     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.5.9903088     Document Type: Article

References (35)

1. Severinghaus, J. W. 1990. Acetazolamide and respiration: theory and uses. Int. Crit. Care Digest 9:32-34.
2. Miller, P. D., and A. S. Berns. 1977. Acute metabolic acidosis perpetuating hypercarbia: a role for acetazolamide in chronic obstructive pulmonary disease. J.A.M.A. 238:2400-2401.
3. Bear, R., M. Goldstein, E. Phillipson, M. Hammeke, R. Feldman, S. Handelsman, and M. Halperin. 1977. Effect of metabolic alkalosis on respiratory function in patients with chronic obstructive lung disease. Can. Med. Assoc. J. 117:900-903.
4. Vos, P. J. E., H. T. M. Folgering, T. M. de Boo, W. J. G. M. Lemmens, and C. L. A. van Herwaarden. 1994. Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD). Eur. Respir. J. 7:850-855.
5. Swenson, E. R. 1998. Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression. Eur. Respir. J. 12:1242-1247.
6. Skatrud, J. B., and J. A. Dempsey. 1983. Relative effectiveness of acetazolamide versus medroxyprogesterone acetate in correction of chronic carbon dioxide retention. Am. Rev. Respir. Dis. 127:405-412.
7. Travis, D. M., C. Wiley, B. R. Nechay, and T. H. Maren. 1964. Selective renal carbonic anhydrase inhibition without respiratory effect: pharmacology of 2-benzene-sulfonamido-1,3,4-thiadizole-5-sulfonamide (CL 11,366). J. Pharm. Exp. Ther. 143:383-394.
8. Swenson, E. R., K. L. Leatham, R. C. Roach, R. B. Schoene, W. J. Mills, and P. H. Hackett. 1991. Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing. Respir. Physiol. 86:333-343.
9. Maren, T. H. 1967. Carbonic anhydrase: chemistry, physiology and inhibition. Physiol. Rev. 47:595-781.
10. Teppema, L., A. Berkenbosch, J. DeGoede, and C. Olievier. 1995. Carbonic anhydrase and the control of breathing: different effects of benzolamide and methazolamide in the anaesthetized cat. J. Physiol. (Lond.) 488:767-777.
11. Roth, L. J., J. C. Schoolar, and C. F. Barlow. 1959. Sulfur-35-labelled acetazolamide in cat brain. J. Pharm. Exp. Ther. 125:128-136.
12. Maren, T. H. 1977. Use of inhibitors in physiological studies of carbonic anhydrase. Am. J. Physiol. 232:F291-F297.
13. 2 response curve in the anaesthetized cat. J. Physiol. (Lond.) 495: 227-237.
14. Teppema, L. J., F. Rochette, and M. Demedts. 1988. Ventilatory effects of carbonic anhydrase inhibition in cats: effects of acetazolamide in intact vs. peripherally chemodenervated animals. Respir. Physiol. 74: 373-382.
15. Teppema, L. J., F. Rochette, and M. Demedts. 1992. Ventilatory effects of acetazolamide in cats during hypoxemia. J. Appl. Physiol. 72:1717-1723.
16. 2, Acetazolamid) auf die Lungenbelüftung Beim Menschen. Pflügers Arch. 270: 450-460.
17. 2 and hypoxia in humans. Jpn. J. Physiol. 36:511-521.
18. Swenson, E. R., and J. M. B. Hughes. 1993. Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in man. J. Appl. Physiol. 73:230-237.
19. Bellville, J. W., B. J. Whipp, R. D. Kaufman, G. D. Swanson, K. A. Aqleh, and D. M. Wiberg. 1979. Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects. J. Appl. Physiol. 46:843-853.
20. DeGoede, J., A. Berkenbosch, D. S. Ward, J. W. Bellville, and C. N. Olievier. 1985. Comparison of chemoreflex gains obtained with two different methods in cats. J. Appl. Physiol. 59:170-179.
21. Dahan, A., E. Sarton, M. van den Elsen, J. van Kleef, L. Teppema, and A. Berkenbosch. 1996. Ventilatory response to hypoxia in humans: influences of subanesthetic desflurane. Anesthesiology 85:60-68.
22. Dempsey, J. A., and H. V. Forster. 1982. Mediation of ventilatory adaptations. Physiol. Rev. 62:262-346.
23. Hayes, M. W., B. K. Maini, and R. W. Torrance. 1976. Reduction of the responses of carotid chemoreceptors by acetazolamide. In A. S. Paintal, editor. Morphology and Mechanisms of Chemoreceptors. Vallabhbhai Patel Chest Institute, Delhi, India. 36-45.
24. Lahiri, S., R. G. Delaney, and A. P. Fishman. 1976. Peripheral and central effects of acetazolamide on the control of ventilation. Physiologist 19:261.
25. Iturriaga, R., S. Lahiri, and A. Mokashi. 1991. Carbonic anhydrase and chemoreception in the cat carotid body. Am. J. Physiol. 261:C565-C573.
26. 2 sensitivities from Read's rebreathing method and the steady state method are not equal. J. Physiol. (Lond.) 411: 367-377.
27. Huang, S. Y., R. E. McCullough, R. G. McCullough, A. J. Micco, M. Manco-Johnson, J. V. Weil, and J. T. Reeves. 1988. Usual clinical dose of acetazolamide does not alter cerebral blood flow velocity. Respir. Physiol. 72:315-326.
28. Torrance, R. W. 1993. Carbonic anhydrase near central chemoreceptors. Adv. Exp. Med. Biol. 337:235-239.
29. Ridderstråle, Y., and M. A. Hanson. 1985. Histochemical study of the distribution of carbonic anhydrase in the cat brain. Acta Physiol. Scand. 124:557-564.
30. 2. Brain Res. 519:23-28.
31. 2 after carbonic anhydrase inhibition with acetazolamide administration in the anesthetized cat. Jpn. J. Physiol. 38:55-65.
32. Linton, R. A. F., P. A. Poole-Wilson, R. J. Davies, and R. J. Cameron. 1973. A comparison of the ventilatory response by steady-state and rebreathing methods during metabolic acidosis and alkalosis. Clin. Sci. Mol. Med. 45:239-249.
33. Dahan, A., A. Berkenbosch, J. DeGoede, I. C. W. Olievier, and J. G. Bovill. 1990. On a pseudo-rebreathing technique to assess the ventilatory sensitivity to carbon dioxide in man. J. Physiol. (Lond.) 423:615-629.
34. Bashir, Y., M. Kann, and J. R. Stradling. 1990. The effect of acetazolamide on hypercapnic and eucapnic/poikilocapnic hypoxic ventilatory responses in normal subjects. Pulm. Pharmacol. 3:151-154.
35. Swenson, E. R., H. T. Robertson, and M. P. Hlastala.1993. Effects of carbonic anhydrase inhibition on ventilation-perfusion matching in the lung. J. Clin. Invest. 92:702-709.