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Volumn 5, Issue 3, 2011, Pages 197-202

Linagliptin and newer DPP-4 inhibitors: Newer uses and newer indications

Author keywords

Diabetes; Dpp4 inhibitors; Hepatic safety; Incretins; Linagliptin; Oral hypoglycemics; Renal safety

Indexed keywords

ALOGLIPTIN; CHOLECYSTOKININ A RECEPTOR; DIGOXIN; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DUTOGLIPTIN; GEMIGLIPTIN; GLIBENCLAMIDE; HEMOGLOBIN A1C; KETOCONAZOLE; LINAGLIPTIN; MELOGLIPTIN; METFORMIN; MOXIFLOXACIN; OMEPRAZOLE; PIOGLITAZONE; RIFAMPICIN; SAXAGLIPTIN; SIMVASTATIN; SITAGLIPTIN; VILDAGLIPTIN;

EID: 80052856736     PISSN: 18722148     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221411797265926     Document Type: Review
Times cited : (7)

References (47)
  • 4
    • 58149119500 scopus 로고    scopus 로고
    • Sitagliptin and vildagliptin: Efficacy of therapy in type 2 diabetes
    • Kirk JK, Oldham EC. Sitagliptin and vildagliptin: Efficacy of therapy in type 2 diabetes. Recent Pat Endocr Metab Immune Drug Discov 2008; 2(3): 162-171.
    • (2008) Recent Pat Endocr Metab Immune Drug Discov , vol.2 , Issue.3 , pp. 162-171
    • Kirk, J.K.1    Oldham, E.C.2
  • 6
    • 42649087085 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes
    • Flatt PR, Bailey CJ, Green BD. Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes. Front Biosci 2008; 13: 3648-3660.
    • (2008) Front Biosci , vol.13 , pp. 3648-3660
    • Flatt, P.R.1    Bailey, C.J.2    Green, B.D.3
  • 7
    • 70349755766 scopus 로고    scopus 로고
    • Linagliptin, a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 Diabetes
    • Tiwari A. Linagliptin, a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 Diabetes. Curr Opin Investing Drugs 2009; 10(10): 1091-1104.
    • (2009) Curr Opin Investing Drugs , vol.10 , Issue.10 , pp. 1091-1104
    • Tiwari, A.1
  • 8
    • 25844459084 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: Potential importance of selectivity over dipeptidyl peptidases 8 and 9
    • Lankas GR, Leiting B, Roy RS, Eiermann GJ, Beconi MG, Biftu T, et al. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: Potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 2005; 54: 2988-2994.
    • (2005) Diabetes , vol.54 , pp. 2988-2994
    • Lankas, G.R.1    Leiting, B.2    Roy, R.S.3    Eiermann, G.J.4    Beconi, M.G.5    Biftu, T.6
  • 9
    • 77951722213 scopus 로고    scopus 로고
    • DPP-4 Inhibitors in Type 2 Diabetes: Importance of selective enzyme inhibition and implications for clinical use
    • Kushner P, Gorrell M. DPP-4 Inhibitors in Type 2 Diabetes: Importance of selective enzyme inhibition and implications for clinical use. J Fam Practice 2010; 59: 2.
    • (2010) J Fam Practice , vol.59 , pp. 2
    • Kushner, P.1    Gorrell, M.2
  • 10
    • 70549096922 scopus 로고    scopus 로고
    • Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition
    • Kirby MS, Yu DM, O'Connor SP, Gorrell MD. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clin Sci 2010;118:31-41.
    • (2010) Clin Sci , vol.118 , pp. 31-41
    • Kirby, M.S.1    Yu, D.M.2    O'Connor, S.P.3    Gorrell, M.D.4
  • 11
    • 67649998759 scopus 로고    scopus 로고
    • Pharmacokinetics, Pharmacodynemics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in made type2 diabetes patients
    • Heise T, Graefe-Modey EU, Huttner S, Ring A, Trommeshauser D, Dugi KA. Pharmacokinetics, Pharmacodynemics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in made type2 diabetes patients. Diabetes Obes Metab 2009; 11: 786-789.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 786-789
    • Heise, T.1    Graefe-Modey, E.U.2    Huttner, S.3    Ring, A.4    Trommeshauser, D.5    Dugi, K.A.6
  • 12
    • 59649105751 scopus 로고    scopus 로고
    • Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3, 7-dihydro-purine-2,6-dione] increases basal glucagon-like peptide1 and improves glycemic control in diabetic rodent models
    • Thomas L, Tadayyon M, Mark M. Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3, 7-dihydro-purine-2,6-dione] increases basal glucagon-like peptide1 and improves glycemic control in diabetic rodent models. J Pharmacol Exp Ther 2009; 328: 556-563.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 556-563
    • Thomas, L.1    Tadayyon, M.2    Mark, M.3
  • 13
    • 77952770226 scopus 로고    scopus 로고
    • Effect of linagliptin (BI 1356) on the steady-state pharmacokinetics of simvastatin
    • GraefeMody U, Huettner S, Stable H, Ring A, Dugi JA. Effect of linagliptin (BI 1356) on the steady-state pharmacokinetics of simvastatin. Int J Clin Pharmacol Ther 2010; 48 (6): 367-374.
    • (2010) Int J Clin Pharmacol Ther , vol.48 , Issue.6 , pp. 367-374
    • Graefemody, U.1    Huettner, S.2    Stable, H.3    Ring, A.4    Dugi, J.A.5
  • 14
    • 77957665412 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetic interaction between of the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers
    • Grafe-Mody EU, Jungik A, Ring A, Woerle HJ, Dugi KA. Evaluation of the pharmacokinetic interaction between of the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers. Intl J Clin Pharmacol Ther 2010; 48 652-661.
    • (2010) Intl J Clin Pharmacol Ther , vol.48 , pp. 652-661
    • Grafe-Mody, E.U.1    Jungik, A.2    Ring, A.3    Woerle, H.J.4    Dugi, K.A.5
  • 15
    • 67650799130 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamics interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects
    • Graefe-Mody EU, Padula S, Ring A, Withopf B, Dugi KA. Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamics interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects. Curr Med Res Opin 2009; 25(8): 1963-1972.
    • (2009) Curr Med Res Opin , vol.25 , Issue.8 , pp. 1963-1972
    • Graefe-Mody, E.U.1    Padula, S.2    Ring, A.3    Withopf, B.4    Dugi, K.A.5
  • 16
    • 79955712959 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea, glyburide in healthy subjects
    • Grafe-Mody U, Rose P, Ring A, Zander K, Iovino M, Woerle HJ. Assessment of the pharmacokinetic interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea, glyburide in healthy subjects. Drug Metab Pharmacokinet 2011;26(2):123-129.
    • (2011) Drug Metab Pharmacokinet , vol.26 , Issue.2 , pp. 123-129
    • Grafe-Mody, U.1    Rose, P.2    Ring, A.3    Zander, K.4    Iovino, M.5    Woerle, H.J.6
  • 17
    • 77954798308 scopus 로고    scopus 로고
    • Linagliptin, a dipeptidyle peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: A phase I, randomized, double-blind, placebo-controolled trial of single and multiple escalatory doses in healthy adult male Japanese subjects
    • Sarashina A, Sesoko S, Nakashina M, Hayashi N, Taniguchi A, Horie Y, et al. Linagliptin, a dipeptidyle peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: A phase I, randomized, double-blind, placebo-controolled trial of single and multiple escalatory doses in healthy adult male Japanese subjects. Clin Therapeutics 2010; 32(6): 1188-1204.
    • (2010) Clin Therapeutics , vol.32 , Issue.6 , pp. 1188-1204
    • Sarashina, A.1    Sesoko, S.2    Nakashina, M.3    Hayashi, N.4    Taniguchi, A.5    Horie, Y.6
  • 18
  • 19
    • 42649121910 scopus 로고    scopus 로고
    • The novel, potent, and selective DPP-4 inhibitor BI 1356 significantly lowers HbA1c after only 4 weeks of treatment in patients with type 2 diabetes (Abstr)
    • Forst T, Uhlig-Laske B, Ring A, Ritzhaupt A, Graefe-Mody EU, Dugi KA. The novel, potent, and selective DPP-4 inhibitor BI 1356 significantly lowers HbA1c after only 4 weeks of treatment in patients with type 2 diabetes (Abstr). Diabetes 2007; 56(Suppl 1): A157.
    • (2007) Diabetes , vol.56 , Issue.1 SUPPL
    • Forst, T.1    Uhlig-Laske, B.2    Ring, A.3    Ritzhaupt, A.4    Graefe-Mody, E.U.5    Dugi, K.A.6
  • 20
    • 78851472527 scopus 로고    scopus 로고
    • Effect of linagliptin monotherapy on glycaemic control and markers of -cell function in patients with inadequately controlled type 2 diabetes: A randomized controlled trial
    • Del Prato S, Barnett AH, Huisman H, Neubacher D, Woerle H-A, Dugi KA. Effect of linagliptin monotherapy on glycaemic control and markers of -cell function in patients with inadequately controlled type 2 diabetes: A randomized controlled trial. Diabetes Obes Metab 2011; 13(3): 258-267.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.3 , pp. 258-267
    • Del, P.S.1    Barnett, A.H.2    Huisman, H.3    Neubacher, D.4    Woerle, H.-A.5    Dugi, K.A.6
  • 21
    • 78649691630 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: A randomized, doubleblind, placebo-controlled study
    • Taskinen MR, Rosenstock J, Tamminen I, Kubiak R, Patel S, Dugi KA, et al. Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: A randomized, doubleblind, placebo-controlled study. Diabetes Obes Metab 2011; 13: 65-74.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 65-74
    • Taskinen, M.R.1    Rosenstock, J.2    Tamminen, I.3    Kubiak, R.4    Patel, S.5    Dugi, K.A.6
  • 22
    • 79953174825 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: A randomized, double-blind, placebo controlled study
    • Gomis R, Esperado R-M, Jones R, Woerle H-J, Dugi K-A. Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: A randomized, double-blind, placebo controlled study. Diabetes Obes Metab 2011; 13(7):653-661.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.7 , pp. 653-661
    • Gomis, R.1    Esperado, R.-M.2    Jones, R.3    Woerle, H.-J.4    Dugi, K.-A.5
  • 23
    • 51849103389 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynemics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase-4 in healthy male volunteers
    • Huttner S, GrafeMody EU, Withopf B, Ring A, Dugi KA. Safety, tolerability, pharmacokinetics and pharmacodynemics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase-4 in healthy male volunteers. J Clin Pharmacol 2008; 48: 1171-1178.
    • (2008) J Clin Pharmacol , vol.48 , pp. 1171-1178
    • Huttner, S.1    Grafemody, E.U.2    Withopf, B.3    Ring, A.4    Dugi, K.A.5
  • 24
    • 79953217579 scopus 로고    scopus 로고
    • The DPP-4 inhibitor Linagliptin does not prolong the QT interval at therapeutic and supratherapeutic doses
    • Ring A, Grafe-Mody U, Port A, Revollo I, Iovino M, Dugi KA. The DPP-4 inhibitor Linagliptin does not prolong the QT interval at therapeutic and supratherapeutic doses. Br J Clin Pharmacol 2011; 72: 39-50.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 39-50
    • Ring, A.1    Grafe-Mody, U.2    Port, A.3    Revollo, I.4    Iovino, M.5    Dugi, K.A.6
  • 26
    • 77953192546 scopus 로고    scopus 로고
    • An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials
    • Ligueros-Saylan M, Foley JE, Schweizer A, Couturier A, Kothny W. An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials. Diabetes Obes Metab 2010;12:495-509.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 495-509
    • Ligueros-Saylan, M.1    Foley, J.E.2    Schweizer, A.3    Couturier, A.4    Kothny, W.5
  • 27
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC. Pancreatitis, pancreatic and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011;141(1):150-156.
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 28
    • 79960720836 scopus 로고    scopus 로고
    • Tradjenta™ (linagliptin) tablets
    • Tradjenta™ (linagliptin) tablets. Highlights of prescribing information. Initial US Approval: (2011).
    • (2011) Highlights of Prescribing InformaTion
  • 29
    • 70349237185 scopus 로고    scopus 로고
    • Angiotensin converting enzyme and dipeptidyl peptidase IV inhibitors. An increased risk of angioedema
    • Grouzmann E, Livio F, Buclin T. Angiotensin converting enzyme and dipeptidyl peptidase IV inhibitors. An increased risk of angioedema. Hypertension 2009; 54: 468.
    • (2009) Hypertension , vol.54 , pp. 468
    • Grouzmann, E.1    Livio, F.2    Buclin, T.3
  • 32
    • 84859752471 scopus 로고    scopus 로고
    • Available at:, [Accessed on January 17
    • Alogliptin delayed at least two years. Available at: www.theheart.org/article/983133.do#bib_1. [Accessed on January 17, 2011].
    • (2011) Alogliptin Delayed At Least Two Years
  • 36
    • 80052869284 scopus 로고    scopus 로고
    • Substituted InidaZole-4 Carboxamides As Cholecystokinin-1 Receptor Modulators
    • Berger, R., Edmondson, S., Hansen, S., Zhu, C. Substituted inidazole-4 carboxamides as cholecystokinin-1 receptor modulators. US20100311649 (2010).
    • (2010) US20100311649
    • Berger, R.1    Edmondson, S.2    Hansen, S.3    Zhu, C.4
  • 37
    • 80052840870 scopus 로고    scopus 로고
    • Combined Use of DPP-4 Inhibitors and Gastrin ComPounds
    • Cruz, A. Combined use of DPP-4 inhibitors and gastrin compounds. US20100144613 (2010).
    • (2010) US20100144613
    • Cruz, A.1
  • 38
    • 80052847572 scopus 로고    scopus 로고
    • Substituted [1,2,4] TriaZolo [1,5-a] Pyrazines As Dipeptidyl Peptidase -IV Inhibitors
    • Biftu, T., Chen, P., Feng, D., Weber, A.E. Substituted [1,2,4] triazolo [1,5-a] pyrazines as dipeptidyl peptidase -IV inhibitors. US7812027 (2010).
    • (2010) US7812027
    • Biftu, T.1    Chen, P.2    Feng, D.3    Weber, A.E.4
  • 39
    • 80052832188 scopus 로고    scopus 로고
    • Aminocyclohexanes As Dipeptidyl Peptidase IV Inhibitors For the Treatment Or Prevention
    • Biftu, T., Cox, J., Feng, D., Mastracchio, A., Qion, X., Weber, A.E. Aminocyclohexanes as dipeptidyl peptidase IV inhibitors for the treatment or prevention. US7750034 (2010).
    • (2010) US7750034
    • Biftu, T.1    Cox, J.2    Feng, D.3    Mastracchio, A.4    Qion, X.5    Weber, A.E.6
  • 41
    • 80052824347 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitors limit myocardial infarct size in a glucose sensitive manner
    • doi: 10.1136/hrt.2010.205781.7
    • Hausenloy DJ, Wynne AM, Theodorou L, Mocanu MM, Yellon DM. Dipeptidyl peptidase IV inhibitors limit myocardial infarct size in a glucose sensitive manner. Heart 2010; 96: e11 doi: 10.1136/hrt.2010.205781.7.
    • Heart 2010 , vol.96
    • Hausenloy, D.J.1    Wynne, A.M.2    Theodorou, L.3    Mocanu, M.M.4    Yellon, D.M.5
  • 43
    • 80052857117 scopus 로고    scopus 로고
    • Vildagliptin For Treating General Peripheral NeuropaThies
    • Hughes, T.E. Vildagliptin for treating general peripheral neuropathies. US20100160408 (2010).
    • (2010) US20100160408
    • Hughes, T.E.1
  • 44
    • 80052850675 scopus 로고    scopus 로고
    • DPP-IV Inhibitors For Treating Neurodegeneration and Cognitive Disorders
    • Hughes, T.E. DPP-IV inhibitors for treating neurodegeneration and cognitive disorders. US20090017015 (2009).
    • (2009) US20090017015
    • Hughes, T.E.1
  • 45
    • 70349739835 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin (BI 1356) improves wound healing in ob/ob mice
    • Linke A, Frank S, Mark M, Klein T. The DPP-4 inhibitor linagliptin (BI 1356) improves wound healing in ob/ob mice. Diabetes 2009;58(Suppl.1):A161.
    • (2009) Diabetes , vol.58 , Issue.1 SUPPL
    • Linke, A.1    Frank, S.2    Mark, M.3    Klein, T.4
  • 46
    • 70350328161 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors, an emerging class for inflammatory disease?
    • Yazbeck R, Howarth GS, Abbott CA. Dipeptidyl peptidase inhibitors, an emerging class for inflammatory disease? Trends Pharmacol Sci 2009; 30:600-607.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 600-607
    • Yazbeck, R.1    Howarth, G.S.2    Abbott, C.A.3
  • 47
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides. Regul Pept 1999; 85 (1): 9-24.
    • (1999) Regul Pept , vol.85 , Issue.1 , pp. 9-24
    • Mentlein, R.1


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