Metabonomic analysis of hepatitis e patients shows deregulated metabolic cycles and abnormalities in amino acid metabolism

Journal of Viral Hepatitis

Volumn 18, Issue 10, 2011, Pages

  Munshi, S U ^a   Taneja, S ^a   Bhavesh, N S ^a   Shastri, J ^b   Aggarwal, R ^c   Jameel, S ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b Kasturba Infectious Disease Hospital   (India)

^c SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

hepatitis E; hepatitis E virus; metabonomics; nuclear magnetic resonance

Indexed keywords

1 METHYLHISTIDINE; 1 METHYLNICOTINAMIDE; 3 AMINOISOBUTANOIC ACID; ACETONE; ADENOSINE; BIOPTERIN; BUTYRIC ACID DERIVATIVE; GLYCEROL; GLYCINE; HISTIDINE DERIVATIVE; IMIDAZOLE; ISOLEUCINE; PROLINE; SALICYLURIC ACID; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ARTICLE; BLOOD LEVEL; CHEMOMETRIC ANALYSIS; CITRIC ACID CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GLYCOLYSIS; HEPATITIS B; HEPATITIS E; HUMAN; KETOACIDOSIS; LACTIC ACIDOSIS; METABOLIC DISORDER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; UREA CYCLE; URINALYSIS;

ADULT; AMINO ACIDS; FEMALE; HEPATITIS B; HEPATITIS E; HUMAN EXPERIMENTATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MIDDLE AGED; PLASMA; URINE;

EID: 80052833360     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2011.01488.x     Document Type: Article

References (49)

1. Emerson SU, Purcell RH,. Hepatitis E virus. In:, Knipe DM, Howley PM, eds. Fields Virology, 5th edn. Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins, 2007: 3047-3058.
2. Aggarwal R, Naik S,. Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol 2009; 24: 1484-1493.
3. Khuroo MS, Kamili S,. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. J Viral Hepat 2003; 10: 61-69. (Pubitemid 36237814)
4. Hamid SS, Atiq M, Shehzad F, et al. Hepatitis E virus superinfection in patients with chronic liver disease. Hepatology 2002; 36: 474-478. (Pubitemid 34810369)
5. Taneja S, Sen S, Gupta VK, Aggarwal R, Jameel S,. Plasma and urine biomarkers in acute viral hepatitis E. Proteome Sci 2009; 7: 39.
6. Dumas M-E, Barton RH, Toye A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 2006; 103: 12511-12516. (Pubitemid 44267289)
7. Nicholson JK, Lindon JC, Holmes E,. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29: 1181-1189.
8. Lindon JC, Nicholson JK, Holmes E, Everett JR,. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids combined with pattern recognition. Concepts Magn Reson 2000; 12: 289-320.
9. Mao Y, Huang X, Yu K, Qu H, Liu C, Chang Y,. Metabonomic analysis of hepatitis B virus-induced liver failure: identification of potential diagnostic biomarkers by fuzzy support vector machine. J Zhejiang Univ Sci B 2008; 9: 474-481. (Pubitemid 351796546)
10. Godoy MM, Lopes EP, Silva RO, et al. Hepatitis C virus infection diagnosis using metabonomics. J Viral Hepat 2010; 17: 854-858.
11. Hewer R, Vorster J, Steffens FE, Meyer D,. Applying biofluid 1H NMR-based metabonomic techniques to distinguish between HIV-1 positive/AIDS patients on antiretroviral treatment and HIV-1 negative individuals. J Pharm Biomed Anal 2006; 41: 1442-1446. (Pubitemid 43775905)
12. 1H-NMR thermometer suitable for cryoprobes. Magn Reson Chem 2006; 45: 175-178.
13. Lindon JC, Nicholson JK, Everette JR,. NMR spectroscopy of biofluids. Ann Rep NMR Spectros 1999; 38: 1-88.
14. 13C NMR spectroscopy of human blood plasma. Anal Chem 1996; 67: 793-811.
15. Tan J, Li QQ, Loganath A, Chong YS, Xiao M, Obbard JP,. Multivariate data analyses of persistent organic pollutants in maternal adipose tissue in Singapore. Environ Sci Technol 2008; 42: 2681-2687. (Pubitemid 351482949)
16. Halbur PG, Kasorndorkbua C, Gilbert C, et al. Comparative pathogenesis of infection of pigs with hepatitis E viruses recovered from a pig and a human. J Clin Microbiol 2001; 39: 918-923. (Pubitemid 32209700)
17. Gupta H, Iyenger B, Tandon BN,. Localization of a new enteric non-A, non-B [HEV] virus in target organ liver. Gastroenterol Jpn 1993; 28: 46-50. (Pubitemid 23114156)
18. Moin SM, Chandra V, Arya R, Jameel S,. The hepatitis E virus ORF3 protein stabilizes HIF-1a and enhances HIF-1-mediated transcriptional activity through p300/CBP. Cell Microbiol 2009; 11: 1409-1421.
19. Pettersena JE, Landaas S, Eldjarn L,. The occurrence of 2-hydroxybutyric acid in urine from patients with lactic acidosis. Clin Chim Acta 1973; 48: 213-219.
20. McGarry JD, Foster DW,. Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem 1980; 49: 395-420.
21. Landaas S,. The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta 1975; 58: 23-32.
22. Landaas S, Pettersen JE,. Clinical conditions associated with urinary excretion of 2-hydroxybutyric acid. Scand J Clin Lab Invest 1975; 35: 259-266.
23. Yang W, Roth KS,. Defect in alpha-ketobutyrate metabolism: a new inborn error. Clin Chim Acta 1985; 145: 173-182. (Pubitemid 15153150)
24. Hutson SM, Fenstermacher D, Mahar C,. Role of mitochondrial transamination in branched chain amino acid metabolism. J Biol Chem 1988; 263: 3618-3625. (Pubitemid 18078949)
25. Hutson SM, Cree TC, Harper AE,. Regulation of leucine and ketoisocaproate metabolism in skeletal muscle. J Biol Chem 1978; 253: 8126-8133. (Pubitemid 9086295)
26. Shinnick FL, Harper AE,. Branched-chain amino acid oxidation by isolated rat tissue preparations. Biochim Biophys Acta 1976; 437: 477-486.
27. Hutson SM, Sweatt AJ, LaNoue KF,. Branched-chain amino acid metabolism: implications for establishing safe intakes. J Nutr 2005; 135: 1557S-1564S. (Pubitemid 40791670)
28. Young SN, Leyton M,. The role of serotonin in human mood and social interaction: insight from altered tryptophan levels. Pharmacol Biochem Behav 2002; 71: 857-865. (Pubitemid 34219235)
29. Hyland K,. Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids. J Nutr 2007; 137: 1568S-1572S. (Pubitemid 46855509)
30. Kaufman S,. The structure of the phenylalanine hydroxylation cofactor. Proc Natl Acad Sci USA 1963; 50: 1085-1090.
31. Weiss G, Thuma PE, Biemba G, Mabeza G, Werner ER, Gordeuk VR,. Cerebrospinal fluid levels of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malaria. J Infect Dis 1998; 177: 1064-1068. (Pubitemid 28155163)
32. Hernandes MS, Troncone LR,. Glycine as a neurotransmitter in the forebrain: a short review. J Neural Transm 2009; 116: 1551-1560.
33. Lu SC,. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 1999; 13: 1169-1183. (Pubitemid 29300363)
34. Bhatia V, Bhardwaj P, Elikkottil J, Batra J, Saraya A,. A 7-day profile of oxidative stress and antioxidant status in patients with acute liver failure. Hepatol Int 2008; 2: 465-470.
35. Swietek K, Juszczyk J,. Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis. J Viral Hepat 1997; 4: 139-141. (Pubitemid 127736549)
36. Kulinsky V, Leonova Z, Kolesnichenko L, Malov I, Danilov Yu,. Glutathione system in erythocytes and plasma in viral hepatitis. Biochem (Moscow) Suppl B: Biomed Chem 2007; 1: 270-275.
37. Quick AJ,. The conjugation of benzoic acid in man. J Biol Chem 1931; 92: 65-85.
38. Binder HJ,. Disorders of Absorption. In:, Kasper DL, Braunwalr E, Fauci AS, Hauser SL, Longo DL, Jameson JL, eds. Harrison's Principles of Internal Medicine, 16th edn. New York: McGraw-Hill, 2005: 1764-1776.
39. Shariff MI, Ladep NG, Cox IJ, et al. Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population. J Proteome Res 2010; 9: 1096-2103.
40. Xue R, Dong L, Wu H, Liu T, Wang J, Shen X,. Gas chromatography/mass spectrometry screening of serum metabolomic biomarkers in hepatitis B virus infected cirrhosis patients. Clin Chem Lab Med 2009; 47: 305-310.
41. Blonde-Cynober F, Aussel C, Cynober L,. Abnormalities in branched-chain amino acid metabolism in cirrhosis: influence of hormonal and nutritional factors and directions for future research. Clin Nutr 1999; 18: 5-13. (Pubitemid 29206365)
42. Khanna S, Gopalan S,. Role of branched-chain amino acids in liver disease: the evidence for and against. Curr Opin Nutr Metab Care 2007; 10: 297-303. (Pubitemid 46596705)
43. Bender HU, Almashanu S, Steel G, et al. Functional consequences of PRODH missense mutations. Am J Hum Genet 2005; 76: 409-420. (Pubitemid 40250521)
44. Yu K, Sheng G, Sheng J, et al. A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis B virus. J Proteome Res 2007; 6: 2413-2419. (Pubitemid 47122338)
45. 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. Liver Int 2008; 28: 1095-2103.
46. Noeman SA, Sharada K, EL-Bena H, Dardery SE, Sawaf KA,. Validity of acute phase proteins and trace metals as adjuncts in viral hepatitis A and B. Indian J Clin Biochem 1994; 9: 40-42.
47. Mas VR, Maluf DG, Archer KJ, Yanek K, Bornstein K, Fisher RA,. Proteomic analysis of HCV cirrhosis and HCV-induced HCC: identifying biomarkers for monitoring HCV-cirrhotic patients awaiting liver transplantation. Transplantation 2009; 87: 143-152.
48. Wishart DS,. Quantitative metabolomics using NMR. Trends Anal Chem 2008; 27: 228-237.
49. Hollywood K, Brison DR, Goodacre R,. Metabolomics: current technologies and future trends. Proteomics 2006; 6: 4716-4723. (Pubitemid 44375842)