Dorsally-derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination

GLIA

Volumn 59, Issue 11, 2011, Pages 1612-1621

  Zhu, Qiang ^a   Whittemore, Scott R ^a,b   Devries, William H ^a,b   Zhao, Xiaofeng ^c   Kuypers, Nicholas J ^a,b   Qiu, Mengsheng ^a,c  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

Cell fate; Cre lox; Pax3; Spinal cord injury; Transcription factor

Indexed keywords

CRE RECOMBINASE; TRANSCRIPTION FACTOR PAX3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; DYNAMICS; EPITHELIUM; HUMAN; MOUSE; MULTIPLE SCLEROSIS; MYELINATION; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION; SPINAL CORD; SPINAL CORD INJURY; STEM CELL;

ANIMALS; ANTIMETABOLITES; AXONS; BROMODEOXYURIDINE; CELL DIFFERENTIATION; DATA INTERPRETATION, STATISTICAL; DEMYELINATING DISEASES; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; LAC OPERON; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MYELIN SHEATH; NEURAL STEM CELLS; OLIGODENDROGLIA; PAIRED BOX TRANSCRIPTION FACTORS; SPINAL CORD; SPINAL CORD INJURIES;

EID: 80052800324     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.21203     Document Type: Article

References (32)

1. Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD. 2004. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306: 2111-2115.
2. Battiste J, Helms AW, Kim EJ, Savage TK, Lagace DC, Mandyam CD, Eisch AJ, Miyoshi G, Johnson JE. 2007. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 134: 285-293.
3. Blakemore WF, Franklin RJ. 2008. Remyelination in experimental models of toxin-induced demyelination. Curr Top Microbiol Immunol 318: 193-212.
4. Blakemore WF, Keirstead HS. 1999. The origin of remyelinating cells in the central nervous system. J Neuroimmunol 98: 69-76.
5. Cai J, Qi Y, Hu X, Tan M, Liu Z, Zhang J, Li Q, Sander M, Qiu M. 2005. Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 45: 41-53.
6. Engleka KA, Gitler AD, Zhang M, Zhou DD, High FA, Epstein JA. 2005. Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Dev Biol 280: 396-406.
7. Fawcett JW, Asher RA. 1999. The glial scar and central nervous system repair. Brain Res Bull 49: 377-391.
8. Fogarty M, Richardson WD, Kessaris N. 2005. A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord. Development 132: 1951-1959.
9. Fok-Seang J, Mathews GA, ffrench-Constant C, Trotter J, Fawcett JW. 1995. Migration of oligodendrocyte precursors on astrocytes and meningeal cells. Dev Biol 171: 1-15.
10. Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P. 1991. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10: 1135-1147.
11. Goulding MD, Lumsden A, Gruss P. 1993. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development 117: 1001-1016.
12. Lee SK, Pfaff SL. 2001. Transcriptional networks regulating neuronal identity in the developing spinal cord. Nat Neurosci 4 Suppl: 1183-1191.
13. McKay JS, Blakemore WF, Franklin RJ. 1998. Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes. Neuropathol Appl Neurobiol 24: 498-506.
14. Miller RH. 2002. Regulation of oligodendrocyte development in the vertebrate CNS. Prog Neurobiol 67: 451-467.
15. Miller RH. 2005. Dorsally derived oligodendrocytes come of age. Neuron 45: 1-3.
16. Miller RH, Dinsio K, Wang R, Geertman R, Maier CE, Hall AK. 2004. Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4. J Neurosci Res 76: 9-19.
17. Novak A, Guo C, Yang W, Nagy A, Lobe CG. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28: 147-155.
18. Orentas DM, Hayes JE, Dyer KL, Miller RH. 1999. Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors. Development 126: 2419-2429.
19. Pringle NP, Yu WP, Guthrie S, Roelink H, Lumsden A, Peterson AC, Richardson WD. 1996. Determination of neuroepithelial cell fate: Induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol 177: 30-42.
20. Richardson WD, Pringle NP, Yu WP, Hall AC. 1997. Origins of spinal cord oligodendrocytes: Possible developmental and evolutionary relationships with motor neurons. Dev Neurosci 19: 58-68.
21. Rowitch DH. 2004. Glial specification in the vertebrate neural tube. Nat Rev Neurosci 5: 409-419.
22. Shimizu T, Kagawa T, Wada T, Muroyama Y, Takada S, Ikenaka K. 2005. Wnt signaling controls the timing of oligodendrocyte development in the spinal cord. Dev Biol 282: 397-410.
23. Sofroniew MV. 2009. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32: 638-647.
24. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71.
25. Spassky N, Olivier C, Perez-Villegas E, Goujet-Zalc C, Martinez S, Thomas J, Zalc B. 2000. Single or multiple oligodendroglial lineages: A controversy. Glia 29: 143-148.
26. Sun T, Pringle NP, Hardy AP, Richardson WD, Smith HK. 1998. Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol Cell Neurosci 12: 228-239.
27. Talbott JF, Loy DN, Liu Y, Qiu MS, Bunge MB, Rao MS, Whittemore SR. 2005. Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol 192: 11-24.
28. Tripathi RB, Clarke LE, Burzomato V, Kessaris N, Anderson PN, Attwell D, Richardson WD. 2011. Dorsally and ventrally derived oligodendrocytes have similar electrical properties but myelinate preferred tracts. J Neurosci 31: 6809-6819.
29. Vallstedt A, Klos JM, Ericson J. 2005. Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45: 55-67.
30. Williams A, Piaton G, Lubetzki C. 2007. Astrocytes-Friends or foes in multiple sclerosis? Glia 55: 1300-1312.
31. Xu X, Cai J, Fu H, Wu R, Qi Y, Modderman G, Liu R, Qiu M. 2000. Selective expression of Nkx-2.2 transcription factor in chicken oligodendrocyte progenitors and implications for the embryonic origin of oligodendrocytes. Mol Cell Neurosci 16: 740-753.
32. Yue T, Xian K, Hurlock E, Xin M, Kernie SG, Parada LF, Lu QR. 2006. A critical role for dorsal progenitors in cortical myelination. J Neurosci 26: 1275-1280.