Analysis of collagen expression during chondrogenic induction of human bone marrow mesenchymal stem cells

Biotechnology Letters

Volumn 33, Issue 10, 2011, Pages 2091-2101

  Perrier, Emeline ^a   Ronzière, Marie Claire ^a   Bareille, Reine ^b   Pinzano, Astrid ^c   Mallein Gerin, Frédéric ^a   Freyria, Anne Marie ^a  

^a University Lyon i   (France)

^b INSERM   (France)

^c Biopôle de l Université de Lorraine   (France)

Author keywords

Bone morphogenetic protein 2, chondrogenesis; Collagen; Fibroblast growth factor 2; Mesenchymal stem cells; Transforming growth factor beta3

Indexed keywords

BONE MARROW; CARTILAGE DEFECTS; CHONDROCYTES; CHONDROGENESIS; CHONDROGENIC; COLLAGEN EXPRESSION; ENHANCING EFFECT; EXTRACELLULAR MATRICES; GENE EXPRESSION LEVELS; HUMAN BONE MARROW MESENCHYMAL STEM CELLS; MESENCHYMAL STEM CELL; TRANSFORMING GROWTH; TYPE II; TYPE IIA;

BONE; CARTILAGE; COLLAGEN; ENZYME INHIBITION; FLOWCHARTING; GENE EXPRESSION; PELLETIZING; STEM CELLS;

CELL CULTURE;

BONE MORPHOGENETIC PROTEIN 2; COL2A1 PROTEIN, HUMAN; COLLAGEN; COLLAGEN TYPE 2; FIBROBLAST GROWTH FACTOR 2; ISOPROTEIN; TRANSFORMING GROWTH FACTOR BETA3;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; BONE MARROW CELL; CELL PROLIFERATION; CHONDROGENESIS; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; CELL PROLIFERATION; CHONDROGENESIS; COLLAGEN; COLLAGEN TYPE II; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELLS; MIDDLE AGED; PROTEIN ISOFORMS; TRANSFORMING GROWTH FACTOR BETA3;

EID: 80052797115     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-011-0653-1     Document Type: Article

References (35)

1. Aigner T, Zhu Y, Chansky HH, Matsen FA 3rd, Maloney WJ, Sandell LJ (1999) Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage. Arthritis Rheum 42: 1443-1450.
2. Alexopoulos LG, Youn I, Bonaldo P, Guilak F (2009) Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. Arthritis Rheum 60: 771-779.
3. Bobick BE, Thornhill TM, Kulyk WM (2007) Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation. J Cell Physiol 211: 233-243.
4. Cortial D, Gouttenoire J, Rousseau CF, Ronziere MC, Piccardi N, Msika P, Herbage D, Mallein-Gerin F, Freyria AM (2006) Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis. Osteoarthr Cartil 14: 631-640.
5. Cournil-Henrionnet C, Huselstein C, Wang Y, Galois L, Mainard D, Decot V, Netter P, Stoltz JF, Muller S, Gillet P, Watrin-Pinzano A (2008) Phenotypic analysis of cell surface markers and gene expression of human mesenchymal stem cells and chondrocytes during monolayer expansion. Biorheology 45: 513-526.
6. Freyria AM, Cortial D, Ronziere MC, Guerret S, Herbage D (2004) Influence of medium composition, static and stirred conditions on the proliferation of and matrix protein expression of bovine articular chondrocytes cultured in a 3-D collagen scaffold. Biomaterials 25: 687-697.
7. Freyria AM, Courtes S, Mallein-Gerin F (2008) [Differentiation of adult human mesenchymal stem cells: chondrogenic effect of BMP-2]. Pathol Biol (Paris) 56: 326-333 in French.
8. Gregory KE, Keene DR, Tufa SF, Lunstrum GP, Morris NP (2001) Developmental distribution of collagen type XII in cartilage: association with articular cartilage and the growth plate. J Bone Miner Res 16: 2005-2016.
9. Hautier A, Salentey V, Aubert-Foucher E, Bougault C, Beauchef G, Ronziere MC, De Sobarnitsky S, Paumier A, Galera P, Piperno M, Damour O, Mallein-Gerin F (2008) Bone morphogenetic protein-2 stimulates chondrogenic expression in human nasal chondrocytes expanded in vitro. Growth Factors 26: 201-211.
10. Hjorten R, Hansen U, Underwood RA, Telfer HE, Fernandes RJ, Krakow D, Sebald E, Wachsmann-Hogiu S, Bruckner P, Jacquet R, Landis WJ, Byers PH, Pace JM (2007) Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Bone 41: 535-542.
11. Karlsson C, Brantsing C, Svensson T, Brisby H, Asp J, Tallheden T, Lindahl A (2007) Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors. J Orthop Res 25: 152-163.
12. Kastrinaki MC, Andreakou I, Charbord P, Papadaki HA (2008) Isolation of human bone marrow mesenchymal stem cells using different membrane markers: comparison of colony/cloning efficiency, differentiation potential, and molecular profile. Tissue Eng C Methods 14: 333-339.
13. Khan WS, Tew SR, Adesida AB, Hardingham TE (2008) Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. Arthritis Res Ther 10(4): R74.
14. Khan WS, Johnson DS, Hardingham TE (2010) The potential of stem cells in the treatment of knee cartilage defects. Knee 17(6): 369-374.
15. Marsano A, Millward-Sadler SJ, Salter DM, Adesida A, Hardingham T, Tognana E, Kon E, Chiari-Grisar C, Nehrer S, Jakob M, Martin I (2007) Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes. Osteoarthr Cartil 15: 48-58.
16. Mehlhorn AT, Schmal H, Kaiser S, Lepski G, Finkenzeller G, Stark GB, Sudkamp NP (2006) Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture. Tissue Eng 12: 1393-1403.
17. Merceron C, Vinatier C, Portron S, Masson M, Amiaud J, Guigand L, Cherel Y, Weiss P, Guicheux J (2009) Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells. Am J Physiol Cell Physiol 298: C355-C364.
18. Miyanishi K, Trindade MC, Lindsey DP, Beaupre GS, Carter DR, Goodman SB, Schurman DJ, Smith RL (2006) Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro. Tissue Eng 12: 2253-2262.
19. Murdoch AD, Grady LM, Ablett MP, Katopodi T, Meadows RS, Hardingham TE (2007) Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage. Stem Cells 25: 2786-2796.
20. Oganesian A, Zhu Y, Sandell LJ (1997) Type IIA procollagen amino propeptide is localized in human embryonic tissues. J Histochem Cytochem 45: 1469-1480.
21. Pelttari K, Winter A, Steck E, Goetzke K, Hennig T, Ochs BG, Aigner T, Richter W (2006) Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54: 3254-3266.
22. Petit B, Freyria AM, van der Rest M, Herbage D (1992) Cartilage collagens. In: Adolphe M (ed) Biological regulation of the chondrocytes. CRC, Boca Raton, pp 33-84.
23. Plumb DA, Dhir V, Mironov A, Ferrara L, Poulsom R, Kadler KE, Thornton DJ, Briggs MD, Boot-Handford RP (2007) Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. J Biol Chem 282: 12791-12795.
24. Poole CA, Gilbert RT, Herbage D, Hartmann DJ (1997) Immunolocalization of type IX collagen in normal and spontaneously osteoarthritic canine tibial cartilage and isolated chondrons. Osteoarthr Cartil 5: 191-204.
25. Ronziere MC, Perrier E, Mallein-Gerin F, Freyria AM (2010) Chondrogenic potential of bone marrow- and adipose tissue-derived adult human mesenchymal stem cells. Biomed Mater Eng 20: 145-158.
26. Sandell LJ, Morris N, Robbins JR, Goldring MB (1991) Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide. J Cell Biol 114: 1307-1319.
27. Schmitt B, Ringe J, Haupl T, Notter M, Manz R, Burmester GR, Sittinger M, Kaps C (2003) BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation 71: 567-577.
28. Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ (2005) Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res 320: 269-276.
29. Shen B, Wei A, Tao H, Diwan AD, Ma DD (2009) BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture. Tissue Eng A 15: 1311-1320.
30. Solchaga LA, Penick K, Porter JD, Goldberg VM, Caplan AI, Welter JF (2005) FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol 203: 398-409.
31. Solchaga LA, Penick K, Goldberg VM, Caplan AI, Welter JF (2010) Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells. Tissue Eng A 16: 1009-1019.
32. Tew SR, Murdoch AD, Rauchenberg RP, Hardingham TE (2008) Cellular methods in cartilage research: primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells. Methods 45: 2-9.
33. Varas L, Ohlsson LB, Honeth G, Olsson A, Bengtsson T, Wiberg C, Bockermann R, Jarnum S, Richter J, Pennington D, Johnstone B, Lundgren-Akerlund E, Kjellman C (2007) Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential. Stem Cells Dev 16: 965-978.
34. Vilamitjana-Amedee J, Bareille R, Rouais F, Caplan AI, Harmand MF (1993) Human bone marrow stromal cells express an osteoblastic phenotype in culture. In Vitro Cell Dev Biol Anim 29A: 699-707.
35. Zhu Y, Oganesian A, Keene DR, Sandell LJ (1999) Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2. J Cell Biol 144: 1069-1080.